The IRE1α Stress Signaling Axis Is a Key Regulator of Neutrophil Antimicrobial Effector Function

Activation of the endoplasmic reticulum stress sensor, IRE1α, is required for effective immune responses against bacterial infection and is associated with human inflammatory diseases in which neutrophils are a key immune component. However, the specific role of IRE1α in regulating neutrophil effect...

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Veröffentlicht in:	The Journal of immunology (1950) 2021-07, Vol.207 (1), p.210-220
Hauptverfasser:	Abuaita, Basel H, Sule, Gautam J, Schultz, Tracey L, Gao, Fushan, Knight, Jason S, O'Riordan, Mary X
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endoribonucleases - immunology Healthy Volunteers Humans Interleukin-1beta - biosynthesis Methicillin-Resistant Staphylococcus aureus - immunology Mice Neutrophils - immunology Protein Serine-Threonine Kinases - immunology Signal Transduction - immunology
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