The interplay of neurovasculature and adult hippocampal neurogenesis
•Neurotrophic factors and growth factors enhance adult hippocampal neurogenesis.•VEGF couples angiogenesis and adult hippocampal neurogenesis.•PV/nNOS interneurons induces functional hyperemia through nitric oxide signaling.•Functional hyperemia enhances adult hippocampal neurogenesis.•Neurovascular...
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| Veröffentlicht in: | Neuroscience letters 2021-08, Vol.760, p.136071-136071, Article 136071 |
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| container_title | Neuroscience letters |
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| creator | Kim, Thomas A. Chen, Lu Ge, Shaoyu |
| description | •Neurotrophic factors and growth factors enhance adult hippocampal neurogenesis.•VEGF couples angiogenesis and adult hippocampal neurogenesis.•PV/nNOS interneurons induces functional hyperemia through nitric oxide signaling.•Functional hyperemia enhances adult hippocampal neurogenesis.•Neurovascular dysfunction is indicated in Alzheimer’s disease.
The subgranular zone of the dentate gyrus provides a local microenvironment (niche) for neural stem cells. In the adult brain, it has been established that the vascular compartment of such niches has a significant role in regulating adult hippocampal neurogenesis. More recently, evidence showed that neurovascular coupling, the relationship between blood flow and neuronal activity, also regulates hippocampal neurogenesis. Here, we review the most recent articles on addressing the intricate relationship between neurovasculature and adult hippocampal neurogenesis and a novel pathway where functional hyperemia enhances hippocampal neurogenesis. In the end, we have further reviewed recent research showing that impaired neurovascular coupling may cause declined neurogenesis and contribute to brain damage in neurodegenerative diseases. |
| doi_str_mv | 10.1016/j.neulet.2021.136071 |
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The subgranular zone of the dentate gyrus provides a local microenvironment (niche) for neural stem cells. In the adult brain, it has been established that the vascular compartment of such niches has a significant role in regulating adult hippocampal neurogenesis. More recently, evidence showed that neurovascular coupling, the relationship between blood flow and neuronal activity, also regulates hippocampal neurogenesis. Here, we review the most recent articles on addressing the intricate relationship between neurovasculature and adult hippocampal neurogenesis and a novel pathway where functional hyperemia enhances hippocampal neurogenesis. In the end, we have further reviewed recent research showing that impaired neurovascular coupling may cause declined neurogenesis and contribute to brain damage in neurodegenerative diseases.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2021.136071</identifier><identifier>PMID: 34147540</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Adult Hippocampal Neurogenesis ; Alzheimer Disease - physiopathology ; Animals ; Blood Brain Barrier ; Dentate Gyrus - blood supply ; Dentate Gyrus - cytology ; Dentate Gyrus - growth & development ; Disease Models, Animal ; Hippocampus ; Humans ; Interneurons - metabolism ; Neovascularization, Physiologic ; Neural Stem Cells - physiology ; Neurogenesis ; Neurovascular Coupling ; Neurovasculature ; Nitric Oxide Synthase Type I - metabolism ; Parvalbumins - metabolism ; Subgranular Zone ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Neuroscience letters, 2021-08, Vol.760, p.136071-136071, Article 136071</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-ac7aecd9e6f2d86cdaadef33ea65f65ef285e8a64d51f79a95a1d9985d7346343</citedby><cites>FETCH-LOGICAL-c463t-ac7aecd9e6f2d86cdaadef33ea65f65ef285e8a64d51f79a95a1d9985d7346343</cites><orcidid>0000-0002-9244-2329</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2021.136071$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34147540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Thomas A.</creatorcontrib><creatorcontrib>Chen, Lu</creatorcontrib><creatorcontrib>Ge, Shaoyu</creatorcontrib><title>The interplay of neurovasculature and adult hippocampal neurogenesis</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>•Neurotrophic factors and growth factors enhance adult hippocampal neurogenesis.•VEGF couples angiogenesis and adult hippocampal neurogenesis.•PV/nNOS interneurons induces functional hyperemia through nitric oxide signaling.•Functional hyperemia enhances adult hippocampal neurogenesis.•Neurovascular dysfunction is indicated in Alzheimer’s disease.
The subgranular zone of the dentate gyrus provides a local microenvironment (niche) for neural stem cells. In the adult brain, it has been established that the vascular compartment of such niches has a significant role in regulating adult hippocampal neurogenesis. More recently, evidence showed that neurovascular coupling, the relationship between blood flow and neuronal activity, also regulates hippocampal neurogenesis. Here, we review the most recent articles on addressing the intricate relationship between neurovasculature and adult hippocampal neurogenesis and a novel pathway where functional hyperemia enhances hippocampal neurogenesis. In the end, we have further reviewed recent research showing that impaired neurovascular coupling may cause declined neurogenesis and contribute to brain damage in neurodegenerative diseases.</description><subject>Adult</subject><subject>Adult Hippocampal Neurogenesis</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Animals</subject><subject>Blood Brain Barrier</subject><subject>Dentate Gyrus - blood supply</subject><subject>Dentate Gyrus - cytology</subject><subject>Dentate Gyrus - growth & development</subject><subject>Disease Models, Animal</subject><subject>Hippocampus</subject><subject>Humans</subject><subject>Interneurons - metabolism</subject><subject>Neovascularization, Physiologic</subject><subject>Neural Stem Cells - physiology</subject><subject>Neurogenesis</subject><subject>Neurovascular Coupling</subject><subject>Neurovasculature</subject><subject>Nitric Oxide Synthase Type I - metabolism</subject><subject>Parvalbumins - metabolism</subject><subject>Subgranular Zone</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUlv2zAQhYmgQews_yAodOxFLilu0qVAkbWAgV6SMzEhRzENWlRJyYD_fRUocdtLT3OY975ZHiHXjK4YZerrdtXhGHBYVbRiK8YV1eyELFmtq1I3uvpElpRTUfJG0AU5z3lLKZVMijOy4IIJLQVdktunDRa-GzD1AQ5FbIuJmuIesh0DDGPCAjpXgBvDUGx830cLux7CLHvFDrPPl-S0hZDx6r1ekOf7u6ebx3L98-HHzfd1aYXiQwlWA1rXoGorVyvrABy2nCMo2SqJbVVLrEEJJ1mrG2gkMNc0tXSaTwDBL8i3mduPLzt0FrshQTB98jtIBxPBm387nd-Y17g3tap5JZoJ8OUdkOKvEfNgdj5bDAE6jGM2lRRcUyGlnKRiltoUc07YHscwat4CMFszB2DeAjBzAJPt898rHk0fH_9zA06P2ntMJluPnUXnE9rBuOj_P-E3H_-b3g</recordid><startdate>20210824</startdate><enddate>20210824</enddate><creator>Kim, Thomas A.</creator><creator>Chen, Lu</creator><creator>Ge, Shaoyu</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9244-2329</orcidid></search><sort><creationdate>20210824</creationdate><title>The interplay of neurovasculature and adult hippocampal neurogenesis</title><author>Kim, Thomas A. ; Chen, Lu ; Ge, Shaoyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-ac7aecd9e6f2d86cdaadef33ea65f65ef285e8a64d51f79a95a1d9985d7346343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Adult Hippocampal Neurogenesis</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Animals</topic><topic>Blood Brain Barrier</topic><topic>Dentate Gyrus - blood supply</topic><topic>Dentate Gyrus - cytology</topic><topic>Dentate Gyrus - growth & development</topic><topic>Disease Models, Animal</topic><topic>Hippocampus</topic><topic>Humans</topic><topic>Interneurons - metabolism</topic><topic>Neovascularization, Physiologic</topic><topic>Neural Stem Cells - physiology</topic><topic>Neurogenesis</topic><topic>Neurovascular Coupling</topic><topic>Neurovasculature</topic><topic>Nitric Oxide Synthase Type I - metabolism</topic><topic>Parvalbumins - metabolism</topic><topic>Subgranular Zone</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Thomas A.</creatorcontrib><creatorcontrib>Chen, Lu</creatorcontrib><creatorcontrib>Ge, Shaoyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Thomas A.</au><au>Chen, Lu</au><au>Ge, Shaoyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The interplay of neurovasculature and adult hippocampal neurogenesis</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2021-08-24</date><risdate>2021</risdate><volume>760</volume><spage>136071</spage><epage>136071</epage><pages>136071-136071</pages><artnum>136071</artnum><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>•Neurotrophic factors and growth factors enhance adult hippocampal neurogenesis.•VEGF couples angiogenesis and adult hippocampal neurogenesis.•PV/nNOS interneurons induces functional hyperemia through nitric oxide signaling.•Functional hyperemia enhances adult hippocampal neurogenesis.•Neurovascular dysfunction is indicated in Alzheimer’s disease.
The subgranular zone of the dentate gyrus provides a local microenvironment (niche) for neural stem cells. In the adult brain, it has been established that the vascular compartment of such niches has a significant role in regulating adult hippocampal neurogenesis. More recently, evidence showed that neurovascular coupling, the relationship between blood flow and neuronal activity, also regulates hippocampal neurogenesis. Here, we review the most recent articles on addressing the intricate relationship between neurovasculature and adult hippocampal neurogenesis and a novel pathway where functional hyperemia enhances hippocampal neurogenesis. In the end, we have further reviewed recent research showing that impaired neurovascular coupling may cause declined neurogenesis and contribute to brain damage in neurodegenerative diseases.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>34147540</pmid><doi>10.1016/j.neulet.2021.136071</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9244-2329</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuroscience letters, 2021-08, Vol.760, p.136071-136071, Article 136071 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Adult Hippocampal Neurogenesis Alzheimer Disease - physiopathology Animals Blood Brain Barrier Dentate Gyrus - blood supply Dentate Gyrus - cytology Dentate Gyrus - growth & development Disease Models, Animal Hippocampus Humans Interneurons - metabolism Neovascularization, Physiologic Neural Stem Cells - physiology Neurogenesis Neurovascular Coupling Neurovasculature Nitric Oxide Synthase Type I - metabolism Parvalbumins - metabolism Subgranular Zone Vascular Endothelial Growth Factor A - metabolism |
| title | The interplay of neurovasculature and adult hippocampal neurogenesis |
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