Functional role and ribosomal position of the unique N-terminal region of DHX29, a factor required for initiation on structured mammalian mRNAs

Abstract Translation initiation on structured mammalian mRNAs requires DHX29, a DExH protein that comprises a unique 534-aa-long N-terminal region (NTR) and a common catalytic DExH core. DHX29 binds to 40S subunits and possesses 40S-stimulated NTPase activity essential for its function. In the cryo-...

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Veröffentlicht in:	Nucleic acids research 2021-12, Vol.49 (22), p.12955-12969
Hauptverfasser:	Sweeney, Trevor R, Dhote, Vidya, Guca, Ewelina, Hellen, Christopher U T, Hashem, Yaser, Pestova, Tatyana V
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Animals Base Sequence Binding Sites - genetics Cryoelectron Microscopy Humans Mammals - genetics Mammals - metabolism Models, Molecular Molecular Biology Mutation Peptide Chain Initiation, Translational - genetics Protein Binding Protein Biosynthesis - genetics Protein Conformation Ribosomes - genetics Ribosomes - metabolism Ribosomes - ultrastructure RNA Helicases - chemistry RNA Helicases - genetics RNA Helicases - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Ribosomal, 18S - genetics RNA, Ribosomal, 18S - metabolism
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