Non-cell autonomous mechanisms control mitochondrial gene dysregulation in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with insulin resistance and impaired energy metabolism in skeletal muscle, the aetiology of which is currently unclear. Here, we mapped the gene expression profile of skeletal muscle from women with PCOS and determined if cul...

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Veröffentlicht in:	Journal of molecular endocrinology 2022-01, Vol.68 (1), p.63-76
Hauptverfasser:	Moreno-Asso, Alba, Altıntaş, Ali, McIlvenna, Luke C, Patten, Rhiannon K, Botella, Javier, McAinch, Andrew J, Rodgers, Raymond J, Barrès, Romain, Stepto, Nigel K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Biopsy Cells, Cultured Cluster Analysis Computational Biology - methods Disease Susceptibility DNA Copy Number Variations Electron transport chain Energy metabolism Epigenetics Extracellular matrix Female Gene expression Gene Expression Profiling Gene Expression Regulation Genes, Mitochondrial Glucose - metabolism Humans Insulin Insulin resistance Metabolism Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - metabolism Musculoskeletal system Myotubes Ovaries Polycystic ovary syndrome Polycystic Ovary Syndrome - etiology Polycystic Ovary Syndrome - metabolism Polycystic Ovary Syndrome - pathology Skeletal muscle Transcriptome Transcriptomics
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