A Computational Solution to Bolster Epigenetic Clock Reliability for Clinical Trials and Longitudinal Tracking

Epigenetic clocks are widely used aging biomarkers, but they are calculated from methylation data for individual CpGs that can be surprisingly unreliable. We report that technical noise causes six major epigenetic clocks to deviate by 3 to 9 years between replicates. We present a novel computational...

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Veröffentlicht in:	Innovation in aging 2021-12, Vol.5 (Supplement_1), p.5-5
Hauptverfasser:	Higgins-Chen, Albert, Thrush, Kyra, Hu-Seliger, Tina, Wang, Yunzhang, Hagg, Sara, Levine, Morgan
Format:	Artikel
Sprache:	eng
Schlagworte:	Abstracts
Online-Zugang:	Volltext
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