Urate transport in health and disease

Circulation of urate levels is determined by the balance between urate production and excretion, homeostasis regulated by the function of urate transporters in key epithelial tissues and cell types. Our understanding of these physiological processes and identification of the genes encoding the urate...

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Veröffentlicht in:	Best practice & research. Clinical rheumatology 2021-12, Vol.35 (4), p.101717-101717, Article 101717
Hauptverfasser:	Halperin Kuhns, Victoria L., Woodward, Owen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCG2 Gout Gout - genetics Humans Hyperuricemia Hyperuricemia - genetics Organic Cation Transport Proteins - genetics SLC22A12 SLC2A9 URAT1 Urate Uric Acid
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creator	Halperin Kuhns, Victoria L. Woodward, Owen M.
description	Circulation of urate levels is determined by the balance between urate production and excretion, homeostasis regulated by the function of urate transporters in key epithelial tissues and cell types. Our understanding of these physiological processes and identification of the genes encoding the urate transporters has advanced significantly, leading to a greater ability to predict risk for urate-associated diseases and identify new therapeutics that directly target urate transport. Here, we review the identified urate transporters and their organization and function in the renal tubule, the intestinal enterocytes, and other important cell types to provide a fuller understanding of the complicated process of urate homeostasis and its role in human diseases. Furthermore, we review the genetic tools that provide an unbiased catalyst for transporter identification as well as discuss the role of transporters in determining the observed significant gender differences in urate-associated disease risk.
doi_str_mv	10.1016/j.berh.2021.101717
format	Article
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subjects	ABCG2 Gout Gout - genetics Humans Hyperuricemia Hyperuricemia - genetics Organic Cation Transport Proteins - genetics SLC22A12 SLC2A9 URAT1 Urate Uric Acid
title	Urate transport in health and disease
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