Solid stress impairs lymphocyte infiltration into lymph-node metastases

Strong and durable anticancer immune responses are associated with the generation of activated cancer-specific T cells in the draining lymph nodes. However, cancer cells can colonize lymph nodes and drive tumour progression. Here, we show that lymphocytes fail to penetrate metastatic lesions in lymp...

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Veröffentlicht in:	Nature biomedical engineering 2021-12, Vol.5 (12), p.1426-1436
Hauptverfasser:	Jones, Dennis, Wang, Zixiong, Chen, Ivy X., Zhang, Sue, Banerji, Rohin, Lei, Pin-Ji, Zhou, Hengbo, Xiao, Victoria, Kwong, Cecilia, van Wijnbergen, Jan Willem M., Pereira, Ethel R., Vakoc, Benjamin J., Huang, Peigen, Nia, Hadi T., Padera, Timothy P.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 14/19 38 38/1 631/67/322 631/67/580 64/60 Animals Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Breast cancer Cancer Colon Engineering Engineering, Biomedical Head & neck cancer Humans Immunotherapy Infiltration Lesions Lymph Nodes Lymphatic Metastasis Lymphatic system Lymphocytes Lymphocytes T Metastases Metastasis Mice Science & Technology T-Lymphocytes Technology Tumors
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