The blood-brain barrier disruption after syncope: a dynamic contrast-enhanced magnetic resonance imaging study: A case report
Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), we demonstrated blood-brain barrier (BBB) disruption following syncope. A 45-year-old man experienced syncope with a chief complaint of syncope (duration: 1 minutes), 1 day before visiting a university hospital for examination. He...
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| Veröffentlicht in: | Medicine (Baltimore) 2021-12, Vol.100 (50), p.e28258-e28258 |
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| creator | Huh, Hyungkyu Lee, Eun-Hee Oh, Sung Suk Kim, Jong-Hoon Seo, Young Beom Choo, Yoo Jin Park, Juyoung Chang, Min Cheol |
| description | Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), we demonstrated blood-brain barrier (BBB) disruption following syncope.
A 45-year-old man experienced syncope with a chief complaint of syncope (duration: 1 minutes), 1 day before visiting a university hospital for examination. He had no history of medical problems and was not taking any medications. This episode was the first in his lifetime.
After syncope, the patient did not have any illnesses or symptoms, such as headache, cognitive deficits, or somnolence.
Cardiac evaluation did not reveal any abnormal findings. In addition, in conventional brain and chest computed tomography and brain MRI, no abnormal lesions were observed.
DCE-MRI of the patient showed bright blue colored lines within the sulci throughout the cerebral cortex. The regions of interest, including bright blue colored lines, had significantly higher Ktrans values (6.86 times higher) than those in healthy control participants. These findings are indicative of BBB disruption of the vessels in the sulci.
Using DCE-MRI, we demonstrated BBB disruption following syncope. DCE-MRI is a useful tool for the detection of BBB disruption following syncope. |
| doi_str_mv | 10.1097/MD.0000000000028258 |
| format | Article |
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A 45-year-old man experienced syncope with a chief complaint of syncope (duration: 1 minutes), 1 day before visiting a university hospital for examination. He had no history of medical problems and was not taking any medications. This episode was the first in his lifetime.
After syncope, the patient did not have any illnesses or symptoms, such as headache, cognitive deficits, or somnolence.
Cardiac evaluation did not reveal any abnormal findings. In addition, in conventional brain and chest computed tomography and brain MRI, no abnormal lesions were observed.
DCE-MRI of the patient showed bright blue colored lines within the sulci throughout the cerebral cortex. The regions of interest, including bright blue colored lines, had significantly higher Ktrans values (6.86 times higher) than those in healthy control participants. These findings are indicative of BBB disruption of the vessels in the sulci.
Using DCE-MRI, we demonstrated BBB disruption following syncope. DCE-MRI is a useful tool for the detection of BBB disruption following syncope.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000028258</identifier><identifier>PMID: 34918695</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Blood-Brain Barrier - diagnostic imaging ; Blood-Brain Barrier - pathology ; Brain ; Clinical Case Report ; Contrast Media - pharmacology ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Syncope - complications ; Syncope - diagnostic imaging</subject><ispartof>Medicine (Baltimore), 2021-12, Vol.100 (50), p.e28258-e28258</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3550-30c4e7345063308b5e10fa7b035d5dca198b2d2131f636fb945d0451bd3c153a3</cites><orcidid>0000-0002-7629-7213</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677986/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677986/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34918695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huh, Hyungkyu</creatorcontrib><creatorcontrib>Lee, Eun-Hee</creatorcontrib><creatorcontrib>Oh, Sung Suk</creatorcontrib><creatorcontrib>Kim, Jong-Hoon</creatorcontrib><creatorcontrib>Seo, Young Beom</creatorcontrib><creatorcontrib>Choo, Yoo Jin</creatorcontrib><creatorcontrib>Park, Juyoung</creatorcontrib><creatorcontrib>Chang, Min Cheol</creatorcontrib><title>The blood-brain barrier disruption after syncope: a dynamic contrast-enhanced magnetic resonance imaging study: A case report</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), we demonstrated blood-brain barrier (BBB) disruption following syncope.
A 45-year-old man experienced syncope with a chief complaint of syncope (duration: 1 minutes), 1 day before visiting a university hospital for examination. He had no history of medical problems and was not taking any medications. This episode was the first in his lifetime.
After syncope, the patient did not have any illnesses or symptoms, such as headache, cognitive deficits, or somnolence.
Cardiac evaluation did not reveal any abnormal findings. In addition, in conventional brain and chest computed tomography and brain MRI, no abnormal lesions were observed.
DCE-MRI of the patient showed bright blue colored lines within the sulci throughout the cerebral cortex. The regions of interest, including bright blue colored lines, had significantly higher Ktrans values (6.86 times higher) than those in healthy control participants. These findings are indicative of BBB disruption of the vessels in the sulci.
Using DCE-MRI, we demonstrated BBB disruption following syncope. DCE-MRI is a useful tool for the detection of BBB disruption following syncope.</description><subject>Blood-Brain Barrier - diagnostic imaging</subject><subject>Blood-Brain Barrier - pathology</subject><subject>Brain</subject><subject>Clinical Case Report</subject><subject>Contrast Media - pharmacology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Syncope - complications</subject><subject>Syncope - diagnostic imaging</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUU1v1DAUtBAVXQq_AAn5yCWtP2I76QGpaoEiteqlPVuO_bIxZO1gJ632wH_Hy5ZS8MXSzLx5ozcIvaPkmJJWnVxfHJO_jzVMNC_QigouK9HK-iVaFVRUqlX1IXqd8zdCKFesfoUOed3SRrZihX7eDoC7MUZXdcn4gDuTkoeEnc9pmWYfAzb9XIC8DTZOcIoNdttgNt5iG8OcTJ4rCIMJFhzemHWAuVAJcgw7DPuC-bDGeV7c9hSfYWsyFH6KaX6DDnozZnj7-B-hu8-fbs8vq6ubL1_Pz64qy4UgFSe2BsVrQSTnpOkEUNIb1REunHDW0LbpmGOU015y2XdtLRypBe0ct-Uehh-hj3vfaek24Czsco96SiVc2upovP6XCX7Q63ivG6lU28hi8OHRIMUfC-RZb3y2MI4mQFyyZpJSWS4vSJHyvdSmmHOC_mkNJXpXnL6-0P8XV6beP0_4NPOnqSKo94KHOJY68vdxeYCkBzDjPPz2E6plFSOMUkYVqQqiCP8F0b6lYA</recordid><startdate>20211217</startdate><enddate>20211217</enddate><creator>Huh, Hyungkyu</creator><creator>Lee, Eun-Hee</creator><creator>Oh, Sung Suk</creator><creator>Kim, Jong-Hoon</creator><creator>Seo, Young Beom</creator><creator>Choo, Yoo Jin</creator><creator>Park, Juyoung</creator><creator>Chang, Min Cheol</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7629-7213</orcidid></search><sort><creationdate>20211217</creationdate><title>The blood-brain barrier disruption after syncope: a dynamic contrast-enhanced magnetic resonance imaging study: A case report</title><author>Huh, Hyungkyu ; Lee, Eun-Hee ; Oh, Sung Suk ; Kim, Jong-Hoon ; Seo, Young Beom ; Choo, Yoo Jin ; Park, Juyoung ; Chang, Min Cheol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3550-30c4e7345063308b5e10fa7b035d5dca198b2d2131f636fb945d0451bd3c153a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Blood-Brain Barrier - diagnostic imaging</topic><topic>Blood-Brain Barrier - pathology</topic><topic>Brain</topic><topic>Clinical Case Report</topic><topic>Contrast Media - pharmacology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Syncope - complications</topic><topic>Syncope - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huh, Hyungkyu</creatorcontrib><creatorcontrib>Lee, Eun-Hee</creatorcontrib><creatorcontrib>Oh, Sung Suk</creatorcontrib><creatorcontrib>Kim, Jong-Hoon</creatorcontrib><creatorcontrib>Seo, Young Beom</creatorcontrib><creatorcontrib>Choo, Yoo Jin</creatorcontrib><creatorcontrib>Park, Juyoung</creatorcontrib><creatorcontrib>Chang, Min Cheol</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huh, Hyungkyu</au><au>Lee, Eun-Hee</au><au>Oh, Sung Suk</au><au>Kim, Jong-Hoon</au><au>Seo, Young Beom</au><au>Choo, Yoo Jin</au><au>Park, Juyoung</au><au>Chang, Min Cheol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The blood-brain barrier disruption after syncope: a dynamic contrast-enhanced magnetic resonance imaging study: A case report</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-12-17</date><risdate>2021</risdate><volume>100</volume><issue>50</issue><spage>e28258</spage><epage>e28258</epage><pages>e28258-e28258</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), we demonstrated blood-brain barrier (BBB) disruption following syncope.
A 45-year-old man experienced syncope with a chief complaint of syncope (duration: 1 minutes), 1 day before visiting a university hospital for examination. He had no history of medical problems and was not taking any medications. This episode was the first in his lifetime.
After syncope, the patient did not have any illnesses or symptoms, such as headache, cognitive deficits, or somnolence.
Cardiac evaluation did not reveal any abnormal findings. In addition, in conventional brain and chest computed tomography and brain MRI, no abnormal lesions were observed.
DCE-MRI of the patient showed bright blue colored lines within the sulci throughout the cerebral cortex. The regions of interest, including bright blue colored lines, had significantly higher Ktrans values (6.86 times higher) than those in healthy control participants. These findings are indicative of BBB disruption of the vessels in the sulci.
Using DCE-MRI, we demonstrated BBB disruption following syncope. DCE-MRI is a useful tool for the detection of BBB disruption following syncope.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>34918695</pmid><doi>10.1097/MD.0000000000028258</doi><orcidid>https://orcid.org/0000-0002-7629-7213</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Blood-Brain Barrier - diagnostic imaging Blood-Brain Barrier - pathology Brain Clinical Case Report Contrast Media - pharmacology Humans Magnetic Resonance Imaging - methods Male Middle Aged Syncope - complications Syncope - diagnostic imaging |
| title | The blood-brain barrier disruption after syncope: a dynamic contrast-enhanced magnetic resonance imaging study: A case report |
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