Early Changes in Skeletal Muscle of Young C22 Mice, A Model of Charcot-Marie-Tooth 1A

Background: The C22 mouse is a Charcot-Marie-Tooth 1A transgenic model with minimal axonal loss. Objective: To analyse early skeletal muscle changes resulting from this dysmyelinating neuropathy. Methods: Histology of tibialis anterior muscles of C22 mice and wild type litter mate controls for morph...

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Veröffentlicht in:	Journal of neuromuscular diseases 2021-11, Vol.8 (s2), p.S283-S299
Hauptverfasser:	Deres, Friederike, Schwartz, Stephanie, Kappes-Horn, Karin, Kornblum, Cornelia, Reimann, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors Age Animals Atrophy Charcot-Marie-Tooth disease Charcot-Marie-Tooth Disease - pathology Denervation Disease Models, Animal Down-regulation Female Histology Humans Initiation factor eIF-2 Membrane proteins Membrane Transport Proteins Mice Morphometry mRNA Muscle, Skeletal - pathology Musculoskeletal system Neuropathy Phenotype Phosphatidylinositol Phosphatidylinositol transfer protein Proteins Research Report Skeletal muscle Western blotting
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