Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy
We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was associated with better cognition (p = .017), while h...
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| Veröffentlicht in: | Journal of neuroimmunology 2020-07, Vol.344, p.577246-577246, Article 577246 |
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| container_title | Journal of neuroimmunology |
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| creator | Amundson, Beret Lai, Lillin Mulligan, Mark J. Xu, Yong Zheng, Zidou Kundu, Suprateek Lennox, Jeffrey L. Waldrop-Valverde, Drenna Franklin, Donald Swaims-Kohlmeier, Alison Letendre, Scott L. Anderson, Albert M. |
| description | We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was associated with better cognition (p = .017), while higher CSF HIV RNA was associated with increased neuronal damage (p = .014). Following 24 weeks of antiretroviral therapy, CD8+ T cells, HLA-DR expressing CD4+ and CD8+ T cells, B cells, NK cells, and non-classical monocyte percentage decreased in CSF. Female gender was negatively associated with cognitive performance over time, as was higher percentage of HLA-DR expressing CD8+ T cells at baseline.
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•CSF CD8+ T cells and other immune effector cells decreased after initiating ART.•Activated CSF immune cells remained more abundant in HIV+ individuals after ART.•Greater CSF CD4+ T cell abundance was associated with better cognition at baseline.•Higher CSF HIV RNA was associated with higher neurofilament light chain at baseline.•Cognitive performance over time was associated with female gender and HLA DR+ CD8+. |
| doi_str_mv | 10.1016/j.jneuroim.2020.577246 |
| format | Article |
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[Display omitted]
•CSF CD8+ T cells and other immune effector cells decreased after initiating ART.•Activated CSF immune cells remained more abundant in HIV+ individuals after ART.•Greater CSF CD4+ T cell abundance was associated with better cognition at baseline.•Higher CSF HIV RNA was associated with higher neurofilament light chain at baseline.•Cognitive performance over time was associated with female gender and HLA DR+ CD8+.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2020.577246</identifier><identifier>PMID: 32371201</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; AIDS ; Antiretroviral Therapy, Highly Active - methods ; Cerebrospinal fluid ; Cognition ; Cognition - drug effects ; Cognition - physiology ; Female ; Flow cytometry ; Follow-Up Studies ; HIV ; HIV Infections - cerebrospinal fluid ; HIV Infections - drug therapy ; HIV Infections - immunology ; Humans ; Immunity, Cellular - drug effects ; Immunity, Cellular - immunology ; Male ; Middle Aged ; Retrospective Studies ; Viral Load - drug effects ; Viral Load - immunology</subject><ispartof>Journal of neuroimmunology, 2020-07, Vol.344, p.577246-577246, Article 577246</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-b67d9ae248bce7d971c3c456a0a03aa44c0abb4fe5d68cddcf9baded79b3f9a33</citedby><cites>FETCH-LOGICAL-c471t-b67d9ae248bce7d971c3c456a0a03aa44c0abb4fe5d68cddcf9baded79b3f9a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165572820300436$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32371201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amundson, Beret</creatorcontrib><creatorcontrib>Lai, Lillin</creatorcontrib><creatorcontrib>Mulligan, Mark J.</creatorcontrib><creatorcontrib>Xu, Yong</creatorcontrib><creatorcontrib>Zheng, Zidou</creatorcontrib><creatorcontrib>Kundu, Suprateek</creatorcontrib><creatorcontrib>Lennox, Jeffrey L.</creatorcontrib><creatorcontrib>Waldrop-Valverde, Drenna</creatorcontrib><creatorcontrib>Franklin, Donald</creatorcontrib><creatorcontrib>Swaims-Kohlmeier, Alison</creatorcontrib><creatorcontrib>Letendre, Scott L.</creatorcontrib><creatorcontrib>Anderson, Albert M.</creatorcontrib><title>Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was associated with better cognition (p = .017), while higher CSF HIV RNA was associated with increased neuronal damage (p = .014). Following 24 weeks of antiretroviral therapy, CD8+ T cells, HLA-DR expressing CD4+ and CD8+ T cells, B cells, NK cells, and non-classical monocyte percentage decreased in CSF. Female gender was negatively associated with cognitive performance over time, as was higher percentage of HLA-DR expressing CD8+ T cells at baseline.
[Display omitted]
•CSF CD8+ T cells and other immune effector cells decreased after initiating ART.•Activated CSF immune cells remained more abundant in HIV+ individuals after ART.•Greater CSF CD4+ T cell abundance was associated with better cognition at baseline.•Higher CSF HIV RNA was associated with higher neurofilament light chain at baseline.•Cognitive performance over time was associated with female gender and HLA DR+ CD8+.</description><subject>Adult</subject><subject>AIDS</subject><subject>Antiretroviral Therapy, Highly Active - methods</subject><subject>Cerebrospinal fluid</subject><subject>Cognition</subject><subject>Cognition - drug effects</subject><subject>Cognition - physiology</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Follow-Up Studies</subject><subject>HIV</subject><subject>HIV Infections - cerebrospinal fluid</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>Humans</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunity, Cellular - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Viral Load - drug effects</subject><subject>Viral Load - immunology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctuFDEQRS0EIkPgFyIv2fTgRz83CBTIQ4rEBthabrt6pkbddmO7J8qP8L24NUkEK1a2VKfuLd1LyAVnW854_eGwPThYgsdpK5hg26ppRFm_IBveNqJoS8Ffkk0Gq6JqRHtG3sR4YIxXsuxekzMpZMMF4xvy-wvGhM4kamAcl1EHitO0OKBz8DOEhBApujwN0AcfZ3R6pMO4oKU6ANUxeoM6gaX3mPbU-J3DhN6tSze3Pwt0A5h1jM7iEe2ix1UwMzr77qh2CQOk4I8YsnLaQ9Dzw1vyasggvHt8z8mPq6_fL2-Ku2_Xt5ef7wpTNjwVfd3YToMo295A_jbcSFNWtWaaSa3L0jDd9-UAla1bY60Zul5bsE3Xy6HTUp6TjyfdeeknsAZcyleoOeCkw4PyGtW_E4d7tfNH1daNkF2VBd4_CgT_a4GY1IRxjVI78EtUGeqErOt29apPqMk5xgDDsw1nai1VHdRTqWotVZ1KzYsXfx_5vPbUYgY-nQDIUR0RgooGwRmwOVqTlPX4P48_U7W-xw</recordid><startdate>20200715</startdate><enddate>20200715</enddate><creator>Amundson, Beret</creator><creator>Lai, Lillin</creator><creator>Mulligan, Mark J.</creator><creator>Xu, Yong</creator><creator>Zheng, Zidou</creator><creator>Kundu, Suprateek</creator><creator>Lennox, Jeffrey L.</creator><creator>Waldrop-Valverde, Drenna</creator><creator>Franklin, Donald</creator><creator>Swaims-Kohlmeier, Alison</creator><creator>Letendre, Scott L.</creator><creator>Anderson, Albert M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200715</creationdate><title>Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy</title><author>Amundson, Beret ; Lai, Lillin ; Mulligan, Mark J. ; Xu, Yong ; Zheng, Zidou ; Kundu, Suprateek ; Lennox, Jeffrey L. ; Waldrop-Valverde, Drenna ; Franklin, Donald ; Swaims-Kohlmeier, Alison ; Letendre, Scott L. ; Anderson, Albert M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-b67d9ae248bce7d971c3c456a0a03aa44c0abb4fe5d68cddcf9baded79b3f9a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>AIDS</topic><topic>Antiretroviral Therapy, Highly Active - methods</topic><topic>Cerebrospinal fluid</topic><topic>Cognition</topic><topic>Cognition - drug effects</topic><topic>Cognition - physiology</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Follow-Up Studies</topic><topic>HIV</topic><topic>HIV Infections - cerebrospinal fluid</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>Humans</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunity, Cellular - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Viral Load - drug effects</topic><topic>Viral Load - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amundson, Beret</creatorcontrib><creatorcontrib>Lai, Lillin</creatorcontrib><creatorcontrib>Mulligan, Mark J.</creatorcontrib><creatorcontrib>Xu, Yong</creatorcontrib><creatorcontrib>Zheng, Zidou</creatorcontrib><creatorcontrib>Kundu, Suprateek</creatorcontrib><creatorcontrib>Lennox, Jeffrey L.</creatorcontrib><creatorcontrib>Waldrop-Valverde, Drenna</creatorcontrib><creatorcontrib>Franklin, Donald</creatorcontrib><creatorcontrib>Swaims-Kohlmeier, Alison</creatorcontrib><creatorcontrib>Letendre, Scott L.</creatorcontrib><creatorcontrib>Anderson, Albert M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amundson, Beret</au><au>Lai, Lillin</au><au>Mulligan, Mark J.</au><au>Xu, Yong</au><au>Zheng, Zidou</au><au>Kundu, Suprateek</au><au>Lennox, Jeffrey L.</au><au>Waldrop-Valverde, Drenna</au><au>Franklin, Donald</au><au>Swaims-Kohlmeier, Alison</au><au>Letendre, Scott L.</au><au>Anderson, Albert M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2020-07-15</date><risdate>2020</risdate><volume>344</volume><spage>577246</spage><epage>577246</epage><pages>577246-577246</pages><artnum>577246</artnum><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was associated with better cognition (p = .017), while higher CSF HIV RNA was associated with increased neuronal damage (p = .014). Following 24 weeks of antiretroviral therapy, CD8+ T cells, HLA-DR expressing CD4+ and CD8+ T cells, B cells, NK cells, and non-classical monocyte percentage decreased in CSF. Female gender was negatively associated with cognitive performance over time, as was higher percentage of HLA-DR expressing CD8+ T cells at baseline.
[Display omitted]
•CSF CD8+ T cells and other immune effector cells decreased after initiating ART.•Activated CSF immune cells remained more abundant in HIV+ individuals after ART.•Greater CSF CD4+ T cell abundance was associated with better cognition at baseline.•Higher CSF HIV RNA was associated with higher neurofilament light chain at baseline.•Cognitive performance over time was associated with female gender and HLA DR+ CD8+.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32371201</pmid><doi>10.1016/j.jneuroim.2020.577246</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neuroimmunology, 2020-07, Vol.344, p.577246-577246, Article 577246 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult AIDS Antiretroviral Therapy, Highly Active - methods Cerebrospinal fluid Cognition Cognition - drug effects Cognition - physiology Female Flow cytometry Follow-Up Studies HIV HIV Infections - cerebrospinal fluid HIV Infections - drug therapy HIV Infections - immunology Humans Immunity, Cellular - drug effects Immunity, Cellular - immunology Male Middle Aged Retrospective Studies Viral Load - drug effects Viral Load - immunology |
| title | Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy |
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