Evaluation of anticancer activity in vitro of a stable copper(I) complex with phosphine-peptide conjugate

[CuI(2,9-dimethyl-1,10-phenanthroline)P(p-OCH 3 -Ph) 2 CH 2 SarcosineGlycine] (1-MPSG), highly stable in physiological media phosphino copper(I) complex—is proposed herein as a viable alternative to anticancer platinum-based drugs. It is noteworthy that, 1-MPSG significantly and selectively reduced...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2021-12, Vol.11 (1), p.23943-23943, Article 23943
Hauptverfasser:	Komarnicka, Urszula K., Pucelik, Barbara, Wojtala, Daria, Lesiów, Monika K., Stochel, Grażyna, Kyzioł, Agnieszka
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92 639/638/263 A549 Cells Adenocarcinoma Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Cancer Caspase Caspase inhibitors Cell cycle Cell death Cell viability Confocal microscopy Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Copper Copper - chemistry Copper - pharmacology Cytotoxicity Drug Screening Assays, Antitumor Flow cytometry Fluorescence spectroscopy HEK293 Cells Humanities and Social Sciences Humans Lung cancer MCF-7 Cells Membrane potential Mitochondria multidisciplinary Multidisciplinary Sciences Neoplasms - drug therapy Neoplasms - metabolism Peptides - chemistry Peptides - pharmacology Phosphine Phosphines - chemistry Phosphines - pharmacology Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!