Transneuronal Degeneration in the Visual Pathway of Rats following Acute Retinal Ischemia/Reperfusion
The maintenance of visual function not only requires the normal structure and function of neurons but also depends on the effective signal propagation of synapses in visual pathways. Synapses emerge alterations of plasticity in the early stages of neuronal damage and affect signal transmission, whic...
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| Veröffentlicht in: | Disease markers 2021, Vol.2021, p.2629150-15 |
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| creator | Fu, Yanyan Hu, Tu Zhang, Qianyue Meng, Shuhan Lu, Ying Xiang, Aiqun Yin, Yewei Li, Yuanjun Song, Jiayu Wen, Dan |
| description | The maintenance of visual function not only requires the normal structure and function of neurons but also depends on the effective signal propagation of synapses in visual pathways. Synapses emerge alterations of plasticity in the early stages of neuronal damage and affect signal transmission, which leads to transneuronal degeneration. In the present study, rat model of acute retinal ischemia/reperfusion (RI/R) was established to observe the morphological changes of neuronal soma and synapses in the inner plexiform layer (IPL), outer plexiform layer (OPL), and dorsal lateral geniculate nucleus (dLGN) after retinal injury. We found transneuronal degeneration in the visual pathways following RI/R concretely presented as edema and mitochondrial hyperplasia of neuronal soma in retina, demyelination, and heterotypic protein clusters of axons in LGN. Meanwhile, small immature synapses formed, and there are asynchronous changes between pre- and postsynaptic components in synapses. This evidence demonstrated that transneuronal degeneration exists in RI/R injury, which may be one of the key reasons for the progressive deterioration of visual function after the injury is removed. |
| doi_str_mv | 10.1155/2021/2629150 |
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Synapses emerge alterations of plasticity in the early stages of neuronal damage and affect signal transmission, which leads to transneuronal degeneration. In the present study, rat model of acute retinal ischemia/reperfusion (RI/R) was established to observe the morphological changes of neuronal soma and synapses in the inner plexiform layer (IPL), outer plexiform layer (OPL), and dorsal lateral geniculate nucleus (dLGN) after retinal injury. We found transneuronal degeneration in the visual pathways following RI/R concretely presented as edema and mitochondrial hyperplasia of neuronal soma in retina, demyelination, and heterotypic protein clusters of axons in LGN. Meanwhile, small immature synapses formed, and there are asynchronous changes between pre- and postsynaptic components in synapses. This evidence demonstrated that transneuronal degeneration exists in RI/R injury, which may be one of the key reasons for the progressive deterioration of visual function after the injury is removed.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2021/2629150</identifier><identifier>PMID: 34917198</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Acute Disease ; Alzheimer's disease ; Animals ; Axons ; Biomarkers - metabolism ; Degeneration ; Demyelination ; Edema ; Female ; Hyperplasia ; Injuries ; Ischemia ; Laboratory animals ; Lateral geniculate nucleus ; Mitochondria ; Nerve Degeneration - etiology ; Nerve Degeneration - metabolism ; Nerve Degeneration - pathology ; Optic nerve ; Pathology ; Proteins ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Reperfusion ; Reperfusion Injury - metabolism ; Reperfusion Injury - pathology ; Retina ; Retina - metabolism ; Retina - pathology ; Signal transmission ; Structure-function relationships ; Synapses ; Visual pathways ; Visual perception ; Visual plasticity ; Visual signals</subject><ispartof>Disease markers, 2021, Vol.2021, p.2629150-15</ispartof><rights>Copyright © 2021 Yanyan Fu et al.</rights><rights>Copyright © 2021 Yanyan Fu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Yanyan Fu et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4290-92c25028a55593f3c73d230607a11c9bcaae0df46c68b6bed4a7e58d355f02d33</citedby><cites>FETCH-LOGICAL-c4290-92c25028a55593f3c73d230607a11c9bcaae0df46c68b6bed4a7e58d355f02d33</cites><orcidid>0000-0002-9103-9175 ; 0000-0001-5653-8481 ; 0000-0003-4212-3087 ; 0000-0003-4741-3876 ; 0000-0001-7813-949X ; 0000-0002-6692-6194 ; 0000-0003-4433-6297 ; 0000-0002-9391-3508 ; 0000-0002-4770-8562</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670974/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670974/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34917198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Su, Ting</contributor><creatorcontrib>Fu, Yanyan</creatorcontrib><creatorcontrib>Hu, Tu</creatorcontrib><creatorcontrib>Zhang, Qianyue</creatorcontrib><creatorcontrib>Meng, Shuhan</creatorcontrib><creatorcontrib>Lu, Ying</creatorcontrib><creatorcontrib>Xiang, Aiqun</creatorcontrib><creatorcontrib>Yin, Yewei</creatorcontrib><creatorcontrib>Li, Yuanjun</creatorcontrib><creatorcontrib>Song, Jiayu</creatorcontrib><creatorcontrib>Wen, Dan</creatorcontrib><title>Transneuronal Degeneration in the Visual Pathway of Rats following Acute Retinal Ischemia/Reperfusion</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>The maintenance of visual function not only requires the normal structure and function of neurons but also depends on the effective signal propagation of synapses in visual pathways. Synapses emerge alterations of plasticity in the early stages of neuronal damage and affect signal transmission, which leads to transneuronal degeneration. In the present study, rat model of acute retinal ischemia/reperfusion (RI/R) was established to observe the morphological changes of neuronal soma and synapses in the inner plexiform layer (IPL), outer plexiform layer (OPL), and dorsal lateral geniculate nucleus (dLGN) after retinal injury. We found transneuronal degeneration in the visual pathways following RI/R concretely presented as edema and mitochondrial hyperplasia of neuronal soma in retina, demyelination, and heterotypic protein clusters of axons in LGN. Meanwhile, small immature synapses formed, and there are asynchronous changes between pre- and postsynaptic components in synapses. 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This evidence demonstrated that transneuronal degeneration exists in RI/R injury, which may be one of the key reasons for the progressive deterioration of visual function after the injury is removed.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34917198</pmid><doi>10.1155/2021/2629150</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-9103-9175</orcidid><orcidid>https://orcid.org/0000-0001-5653-8481</orcidid><orcidid>https://orcid.org/0000-0003-4212-3087</orcidid><orcidid>https://orcid.org/0000-0003-4741-3876</orcidid><orcidid>https://orcid.org/0000-0001-7813-949X</orcidid><orcidid>https://orcid.org/0000-0002-6692-6194</orcidid><orcidid>https://orcid.org/0000-0003-4433-6297</orcidid><orcidid>https://orcid.org/0000-0002-9391-3508</orcidid><orcidid>https://orcid.org/0000-0002-4770-8562</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Alzheimer's disease Animals Axons Biomarkers - metabolism Degeneration Demyelination Edema Female Hyperplasia Injuries Ischemia Laboratory animals Lateral geniculate nucleus Mitochondria Nerve Degeneration - etiology Nerve Degeneration - metabolism Nerve Degeneration - pathology Optic nerve Pathology Proteins Random Allocation Rats Rats, Sprague-Dawley Reperfusion Reperfusion Injury - metabolism Reperfusion Injury - pathology Retina Retina - metabolism Retina - pathology Signal transmission Structure-function relationships Synapses Visual pathways Visual perception Visual plasticity Visual signals |
| title | Transneuronal Degeneration in the Visual Pathway of Rats following Acute Retinal Ischemia/Reperfusion |
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