Dietary sugar restriction reduces hepatic de novo lipogenesis in boys with fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) in children resulting from the obesity epidemic is widespread and increasing. Although the complexities of pediatric NAFLD are recognized, screening and therapies in children remain limited. Moreover, pediatric NAFLD diagnosis fails to consider insulin resist...
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| Veröffentlicht in: | The Journal of clinical investigation 2021-12, Vol.131 (24) |
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| creator | Chung, Stephanie T Magge, Sheela N |
| description | Nonalcoholic fatty liver disease (NAFLD) in children resulting from the obesity epidemic is widespread and increasing. Although the complexities of pediatric NAFLD are recognized, screening and therapies in children remain limited. Moreover, pediatric NAFLD diagnosis fails to consider insulin resistance and metabolic dysfunction as important determinants. In this issue of the JCI, Cohen et al. explored the contribution of dietary factors to the pathogenesis of NAFLD in adolescent boys with biopsy-proven NAFLD and control participants. Notably, dietary sugar restriction over 8 weeks decreased de novo lipogenesis (DNL) and hepatic fat. The change in DNL correlated with changes in insulin and weight, but not with changes in hepatic fat, supporting the relevance of metabolic dysfunction to NAFLD. These results confirm the pathological link between excessive dietary sugar intake and NAFLD in children and support recent recommendations to change the nomenclature of NAFLD to metabolic associated fatty liver disease (MAFLD). |
| doi_str_mv | 10.1172/JCI154645 |
| format | Article |
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These results confirm the pathological link between excessive dietary sugar intake and NAFLD in children and support recent recommendations to change the nomenclature of NAFLD to metabolic associated fatty liver disease (MAFLD).</description><subject>Adolescent</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Development and progression</subject><subject>Dietary Sugars - metabolism</subject><subject>Fatty liver</subject><subject>Glucose metabolism</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lipid metabolism</subject><subject>Lipogenesis</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Non-alcoholic Fatty Liver Disease - metabolism</subject><subject>Sugars - metabolism</subject><issn>1558-8238</issn><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl2L1DAUhoso7rp64R-QgCB60TVpkza5EZbxa2Rhwa9LQyY5aSOdZkzS0fn3puw6zMBcSC5yyHnOG_LmLYqnBF8S0lavPy2WhNGGsnvFOWGMl7yq-f2D-qx4FONPjAmljD4szmoqcCtwc178eOsgqbBDcepUQAFiCk4n58dcm0lDRD1sVHIaGUCj33o0uI3vYIToInIjWvldRL9d6pFVKe1yewsBGRdBRXhcPLBqiPDkbr8ovr1_93Xxsby--bBcXF2XmgrKSmg5tbgBha1QbaWNBSVsTbkyhBHLFNCKV1xxsqKMUyYaQ6yhtjWMYb4S9UXx5lZ3M63WYDSMKahBboJb58dJr5w87oyul53fSt60mDd1Fnh5JxD8rym7INcuahgGNYKfoqwagikhop3R57dopwaQbrQ-K-oZl1cNF6IVdd1mqjxBzb7l6_0I1uXjI_7yBJ-XgbXTJwdeHQ1kJsGf1KkpRrn88vn_2Zvvx-yLA7YHNaQ--mGaMxFPiurgYwxg93YTLOdcyn0uM_vs8H_25L8g1n8BR0LbTg</recordid><startdate>20211215</startdate><enddate>20211215</enddate><creator>Chung, Stephanie T</creator><creator>Magge, Sheela N</creator><general>American Society for Clinical Investigation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6989-0417</orcidid><orcidid>https://orcid.org/0000-0002-0949-4399</orcidid></search><sort><creationdate>20211215</creationdate><title>Dietary sugar restriction reduces hepatic de novo lipogenesis in boys with fatty liver disease</title><author>Chung, Stephanie T ; Magge, Sheela N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4945-e784f06ea0f9a72cdfea9f348ad151f5ae42828a81b4584596d1fd4f7d5508b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Development and progression</topic><topic>Dietary Sugars - metabolism</topic><topic>Fatty liver</topic><topic>Glucose metabolism</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Lipid metabolism</topic><topic>Lipogenesis</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Non-alcoholic Fatty Liver Disease - metabolism</topic><topic>Sugars - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Stephanie T</creatorcontrib><creatorcontrib>Magge, Sheela N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Stephanie T</au><au>Magge, Sheela N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary sugar restriction reduces hepatic de novo lipogenesis in boys with fatty liver disease</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>2021-12-15</date><risdate>2021</risdate><volume>131</volume><issue>24</issue><issn>1558-8238</issn><issn>0021-9738</issn><eissn>1558-8238</eissn><abstract>Nonalcoholic fatty liver disease (NAFLD) in children resulting from the obesity epidemic is widespread and increasing. 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| subjects | Adolescent Care and treatment Child Development and progression Dietary Sugars - metabolism Fatty liver Glucose metabolism Health aspects Humans Lipid metabolism Lipogenesis Liver - metabolism Male Non-alcoholic Fatty Liver Disease - metabolism Sugars - metabolism |
| title | Dietary sugar restriction reduces hepatic de novo lipogenesis in boys with fatty liver disease |
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