Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation

Circular RNAs (circRNAs) have been recently recognized as playing a role in the pathogenesis of vascular remodeling-related diseases by modulating the functions of miRNAs. However, the interplay between circRNAs and proteins during vascular remodeling remains poorly understood. Here, we investigated...

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Veröffentlicht in:	The Journal of clinical investigation 2021-12, Vol.131 (24), p.0_1-18
Hauptverfasser:	Gong, Xue, Tian, Miao, Cao, Nian, Yang, Peili, Xu, Zaicheng, Zheng, Shuo, Liao, Qiao, Chen, Caiyu, Zeng, Cindy, Jose, Pedro A, Wang, Da-Zhi, Jian, Zhao, Xiao, Yingbin, Jiang, Ding-Sheng, Wei, Xiang, Zhang, Bing, Wang, Yibin, Chen, Ken, Wu, Gengze, Zeng, Chunyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Arteriosclerosis Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Biomedical research Cardiovascular disease Care and treatment Carotid arteries Carotid artery Cell migration Cell Proliferation Circular RNA Cyclin D1 Development and progression Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene expression Genetic aspects Genetic screening Health aspects Hyperplasia Hyperplasia - genetics Hyperplasia - metabolism Localization Mice Mice, Knockout, ApoE MicroRNA Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - metabolism p53 Protein Proteins Ribonucleic acid RNA RNA Splicing RNA, Circular - genetics RNA, Circular - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Smooth muscle Splicing Factor U2AF - genetics Splicing Factor U2AF - metabolism Splicing factors Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics Vascular Remodeling
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