The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implications

Acute kidney injury (AKI) is both a consequence and determinant of outcomes in COVID-19. The kidney is one of the major organs infected by the causative virus, SARS-CoV-2. Viral entry into cells requires the viral spike protein, and both the virus and its spike protein appear in the urine of COVID-1...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2022-03, Vol.1868 (3), p.166322-166322, Article 166322
Hauptverfasser:	Singh, Raman Deep, Barry, Michael A., Croatt, Anthony J., Ackerman, Allan W., Grande, Joseph P., Diaz, Rosa M., Vile, Richard G., Agarwal, Anupam, Nath, Karl A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute kidney injury Angiotensin-converting enzyme 2 Animals Cell Line Chlorocebus aethiops COVID-19 COVID-19 - metabolism COVID-19 - virology HEK293 Cells Heme oxygenase-1 Heme Oxygenase-1 - metabolism Host-Pathogen Interactions - drug effects Host-Pathogen Interactions - physiology Humans Protein Binding - drug effects Protein Binding - physiology Quercetin - pharmacology SARS-CoV-2 SARS-CoV-2 - pathogenicity Signal Transduction - drug effects Signal Transduction - physiology Spike Glycoprotein, Coronavirus - metabolism Spike protein Syncytia Up-Regulation - drug effects Up-Regulation - physiology Vero Cells Virus Internalization - drug effects
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