Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites

The ring-like structural maintenance of chromosomes (SMC) complex MukBEF folds the genome of Escherichia coli and related bacteria into large loops, presumably by active DNA loop extrusion. MukBEF activity within the replication terminus macrodomain is suppressed by the sequence-specific unloader Ma...

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Veröffentlicht in:	Molecular cell 2021-12, Vol.81 (23), p.4891-4906.e8
Hauptverfasser:	Bürmann, Frank, Funke, Louise F.H., Chin, Jason W., Löwe, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - chemistry Cell Cycle Proteins - chemistry Chromosomal Proteins, Non-Histone - chemistry chromosome organization Chromosomes - ultrastructure Chromosomes, Bacterial cohesin Cohesins condensin cryo-EM Cryoelectron Microscopy - methods Dimerization DNA - chemistry DNA - metabolism DNA Repair DNA-Binding Proteins - chemistry Escherichia coli - metabolism Escherichia coli Proteins - chemistry Genetic Techniques Genome, Bacterial loop extrusion MukBEF Multiprotein Complexes - chemistry Photorhabdus Protein Binding Protein Conformation Protein Domains Repressor Proteins - chemistry SMC
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