Corneal Cross-Linking for Keratoconus and Post-LASIK Ectasia and Failure Rate: A 3 Years Follow-Up Study
Purpose To report the response of keratoconus (KC) and post-LASIK ectasia (referred to as "ectasia") to the corneal crosslinking (CXL) and to compare the rate of progression between KC and ectasia at three years. Methods A retrospective cohort study of patients undergoing CXL for either KC...
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| creator | Chanbour, Wassef El Zein, Lulwa Younes, Mohamad Ali Issa, Mohamad Warhekar, Pramod Chelala, Elias Jarade, Elias |
| description | Purpose To report the response of keratoconus (KC) and post-LASIK ectasia (referred to as "ectasia") to the corneal crosslinking (CXL) and to compare the rate of progression between KC and ectasia at three years. Methods A retrospective cohort study of patients undergoing CXL for either KC or ectasia. Fifty-four eyes (31 patients) with ectasia and 111 eyes (67 patients) with KC were included in the study. Corrected distance visual acuities (CDVA), refraction, keratometry (K), and pachymetry were followed up for three years. Simultaneous photorefractive keratectomy (PRK) and CXL were performed on 20 KC and 20 ectasia eyes. Intrastromal Corneal Ring Segments (ICRS) were performed on 51 KC and six ectasia eyes. Results In KC, CDVA, spherical equivalence, sphere, cylinder, and mean K improved at three years post-CXL (p-value |
| doi_str_mv | 10.7759/cureus.19552 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8669145</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2622970545</sourcerecordid><originalsourceid>FETCH-LOGICAL-c304t-48606523a2423b21cdacd63f00b220c49d9ca4d3e66d2b520010a70fde819ec73</originalsourceid><addsrcrecordid>eNpdkc1P4zAQxS0EAsRy47yyxIUD6fordsIBqapaqKi0q2U5cLKmtgNhU7vYCYj_nrQFBJxmNPPT07x5CB1RMlAqL3-ZLrouDWiZ52wL7TMqi6yghdj-1O-hw5QeCCGUKEYU2UV7XJRUCS720f0oRO-gwaMYUspmtf9f-ztchYivXIQ2mOC7hMFb_CekNpsNr6dXeGxaSDWsxxOom_4K_Bdad4aHmONbBzHhSWia8JzdLPF129mXH2ingia5w7d6gG4m43-jy2z2-2I6Gs4yw4loM1FIInPGgQnG54waC8ZKXhEyZ4wYUdrSgLDcSWnZPGcrV6BIZV1BS2cUP0DnG91lN184a5xvIzR6GesFxBcdoNZfN76-13fhSRdSllTkvcDJm0AMj51LrV7UybimAe9ClzSTlMpc9R_v0eNv6EPoou_t9RRjpSL5WvB0Q5nVi6OrPo6hRK9S1JsU9TrFHv_52cAH_J4ZfwXuGZgK</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2622970545</pqid></control><display><type>article</type><title>Corneal Cross-Linking for Keratoconus and Post-LASIK Ectasia and Failure Rate: A 3 Years Follow-Up Study</title><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Chanbour, Wassef ; El Zein, Lulwa ; Younes, Mohamad Ali ; Issa, Mohamad ; Warhekar, Pramod ; Chelala, Elias ; Jarade, Elias</creator><creatorcontrib>Chanbour, Wassef ; El Zein, Lulwa ; Younes, Mohamad Ali ; Issa, Mohamad ; Warhekar, Pramod ; Chelala, Elias ; Jarade, Elias</creatorcontrib><description>Purpose To report the response of keratoconus (KC) and post-LASIK ectasia (referred to as "ectasia") to the corneal crosslinking (CXL) and to compare the rate of progression between KC and ectasia at three years. Methods A retrospective cohort study of patients undergoing CXL for either KC or ectasia. Fifty-four eyes (31 patients) with ectasia and 111 eyes (67 patients) with KC were included in the study. Corrected distance visual acuities (CDVA), refraction, keratometry (K), and pachymetry were followed up for three years. Simultaneous photorefractive keratectomy (PRK) and CXL were performed on 20 KC and 20 ectasia eyes. Intrastromal Corneal Ring Segments (ICRS) were performed on 51 KC and six ectasia eyes. Results In KC, CDVA, spherical equivalence, sphere, cylinder, and mean K improved at three years post-CXL (p-value<0.05), but these values improved without reaching a statistical significance in ectasia(p-values <0.05). 12 of 54 eyes with ectasia (22.2%) and 4 of 111 eyes (3.6%) with KC had progression post CXL(p-value:0.0001). Ectasia patients diagnosed with progression were older at presentation (36.1 years) than non-progressive ectasia patients (31 years) (p-value 0.02) and also older than KC patients. Sub-analysis excluding PRK and ICRS cases showed that there was an improvement in mean sphere (from -5.23±4.2D to-4.46±3.89D) (p-value 0.03) cylinder (from 2.54 ± 1.68D to 1.97 ± 1.51D) (p-value 0.03) mean keratometry (from 46.81 ± 3.78D to 46.01 ± 3.25D) (p-value 0.006) in KC patients 3 years post CXL (40 patients). Compared to baseline, all the mean refractive and topographic variables deteriorated at three years post CXL in ectasia (28 patients) (p-value>0.05). Also, 2 of 40 patients with KC (5%) vs. 7 of 28 patients with ectasia (25%) had progression three years post-CXL, and the difference between both groups remained statistically significant(p-value 0.027). Conclusion Eyes with post-LASIK ectasia seem to be less responsive to CXL than KC.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.19552</identifier><identifier>PMID: 34917434</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Contact lenses ; Cornea ; Laboratories ; Ophthalmology ; Patients ; Statistical analysis ; Topography ; Variables ; Vitamin B</subject><ispartof>Curēus (Palo Alto, CA), 2021-11, Vol.13 (11), p.e19552-e19552</ispartof><rights>Copyright © 2021, Chanbour et al.</rights><rights>Copyright © 2021, Chanbour et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2021, Chanbour et al. 2021 Chanbour et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c304t-48606523a2423b21cdacd63f00b220c49d9ca4d3e66d2b520010a70fde819ec73</citedby><cites>FETCH-LOGICAL-c304t-48606523a2423b21cdacd63f00b220c49d9ca4d3e66d2b520010a70fde819ec73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669145/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669145/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34917434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chanbour, Wassef</creatorcontrib><creatorcontrib>El Zein, Lulwa</creatorcontrib><creatorcontrib>Younes, Mohamad Ali</creatorcontrib><creatorcontrib>Issa, Mohamad</creatorcontrib><creatorcontrib>Warhekar, Pramod</creatorcontrib><creatorcontrib>Chelala, Elias</creatorcontrib><creatorcontrib>Jarade, Elias</creatorcontrib><title>Corneal Cross-Linking for Keratoconus and Post-LASIK Ectasia and Failure Rate: A 3 Years Follow-Up Study</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Purpose To report the response of keratoconus (KC) and post-LASIK ectasia (referred to as "ectasia") to the corneal crosslinking (CXL) and to compare the rate of progression between KC and ectasia at three years. Methods A retrospective cohort study of patients undergoing CXL for either KC or ectasia. Fifty-four eyes (31 patients) with ectasia and 111 eyes (67 patients) with KC were included in the study. Corrected distance visual acuities (CDVA), refraction, keratometry (K), and pachymetry were followed up for three years. Simultaneous photorefractive keratectomy (PRK) and CXL were performed on 20 KC and 20 ectasia eyes. Intrastromal Corneal Ring Segments (ICRS) were performed on 51 KC and six ectasia eyes. Results In KC, CDVA, spherical equivalence, sphere, cylinder, and mean K improved at three years post-CXL (p-value<0.05), but these values improved without reaching a statistical significance in ectasia(p-values <0.05). 12 of 54 eyes with ectasia (22.2%) and 4 of 111 eyes (3.6%) with KC had progression post CXL(p-value:0.0001). Ectasia patients diagnosed with progression were older at presentation (36.1 years) than non-progressive ectasia patients (31 years) (p-value 0.02) and also older than KC patients. Sub-analysis excluding PRK and ICRS cases showed that there was an improvement in mean sphere (from -5.23±4.2D to-4.46±3.89D) (p-value 0.03) cylinder (from 2.54 ± 1.68D to 1.97 ± 1.51D) (p-value 0.03) mean keratometry (from 46.81 ± 3.78D to 46.01 ± 3.25D) (p-value 0.006) in KC patients 3 years post CXL (40 patients). Compared to baseline, all the mean refractive and topographic variables deteriorated at three years post CXL in ectasia (28 patients) (p-value>0.05). Also, 2 of 40 patients with KC (5%) vs. 7 of 28 patients with ectasia (25%) had progression three years post-CXL, and the difference between both groups remained statistically significant(p-value 0.027). Conclusion Eyes with post-LASIK ectasia seem to be less responsive to CXL than KC.</description><subject>Contact lenses</subject><subject>Cornea</subject><subject>Laboratories</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Statistical analysis</subject><subject>Topography</subject><subject>Variables</subject><subject>Vitamin B</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1P4zAQxS0EAsRy47yyxIUD6fordsIBqapaqKi0q2U5cLKmtgNhU7vYCYj_nrQFBJxmNPPT07x5CB1RMlAqL3-ZLrouDWiZ52wL7TMqi6yghdj-1O-hw5QeCCGUKEYU2UV7XJRUCS720f0oRO-gwaMYUspmtf9f-ztchYivXIQ2mOC7hMFb_CekNpsNr6dXeGxaSDWsxxOom_4K_Bdad4aHmONbBzHhSWia8JzdLPF129mXH2ingia5w7d6gG4m43-jy2z2-2I6Gs4yw4loM1FIInPGgQnG54waC8ZKXhEyZ4wYUdrSgLDcSWnZPGcrV6BIZV1BS2cUP0DnG91lN184a5xvIzR6GesFxBcdoNZfN76-13fhSRdSllTkvcDJm0AMj51LrV7UybimAe9ClzSTlMpc9R_v0eNv6EPoou_t9RRjpSL5WvB0Q5nVi6OrPo6hRK9S1JsU9TrFHv_52cAH_J4ZfwXuGZgK</recordid><startdate>20211113</startdate><enddate>20211113</enddate><creator>Chanbour, Wassef</creator><creator>El Zein, Lulwa</creator><creator>Younes, Mohamad Ali</creator><creator>Issa, Mohamad</creator><creator>Warhekar, Pramod</creator><creator>Chelala, Elias</creator><creator>Jarade, Elias</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211113</creationdate><title>Corneal Cross-Linking for Keratoconus and Post-LASIK Ectasia and Failure Rate: A 3 Years Follow-Up Study</title><author>Chanbour, Wassef ; El Zein, Lulwa ; Younes, Mohamad Ali ; Issa, Mohamad ; Warhekar, Pramod ; Chelala, Elias ; Jarade, Elias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-48606523a2423b21cdacd63f00b220c49d9ca4d3e66d2b520010a70fde819ec73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Contact lenses</topic><topic>Cornea</topic><topic>Laboratories</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Statistical analysis</topic><topic>Topography</topic><topic>Variables</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chanbour, Wassef</creatorcontrib><creatorcontrib>El Zein, Lulwa</creatorcontrib><creatorcontrib>Younes, Mohamad Ali</creatorcontrib><creatorcontrib>Issa, Mohamad</creatorcontrib><creatorcontrib>Warhekar, Pramod</creatorcontrib><creatorcontrib>Chelala, Elias</creatorcontrib><creatorcontrib>Jarade, Elias</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chanbour, Wassef</au><au>El Zein, Lulwa</au><au>Younes, Mohamad Ali</au><au>Issa, Mohamad</au><au>Warhekar, Pramod</au><au>Chelala, Elias</au><au>Jarade, Elias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corneal Cross-Linking for Keratoconus and Post-LASIK Ectasia and Failure Rate: A 3 Years Follow-Up Study</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2021-11-13</date><risdate>2021</risdate><volume>13</volume><issue>11</issue><spage>e19552</spage><epage>e19552</epage><pages>e19552-e19552</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Purpose To report the response of keratoconus (KC) and post-LASIK ectasia (referred to as "ectasia") to the corneal crosslinking (CXL) and to compare the rate of progression between KC and ectasia at three years. Methods A retrospective cohort study of patients undergoing CXL for either KC or ectasia. Fifty-four eyes (31 patients) with ectasia and 111 eyes (67 patients) with KC were included in the study. Corrected distance visual acuities (CDVA), refraction, keratometry (K), and pachymetry were followed up for three years. Simultaneous photorefractive keratectomy (PRK) and CXL were performed on 20 KC and 20 ectasia eyes. Intrastromal Corneal Ring Segments (ICRS) were performed on 51 KC and six ectasia eyes. Results In KC, CDVA, spherical equivalence, sphere, cylinder, and mean K improved at three years post-CXL (p-value<0.05), but these values improved without reaching a statistical significance in ectasia(p-values <0.05). 12 of 54 eyes with ectasia (22.2%) and 4 of 111 eyes (3.6%) with KC had progression post CXL(p-value:0.0001). Ectasia patients diagnosed with progression were older at presentation (36.1 years) than non-progressive ectasia patients (31 years) (p-value 0.02) and also older than KC patients. Sub-analysis excluding PRK and ICRS cases showed that there was an improvement in mean sphere (from -5.23±4.2D to-4.46±3.89D) (p-value 0.03) cylinder (from 2.54 ± 1.68D to 1.97 ± 1.51D) (p-value 0.03) mean keratometry (from 46.81 ± 3.78D to 46.01 ± 3.25D) (p-value 0.006) in KC patients 3 years post CXL (40 patients). Compared to baseline, all the mean refractive and topographic variables deteriorated at three years post CXL in ectasia (28 patients) (p-value>0.05). Also, 2 of 40 patients with KC (5%) vs. 7 of 28 patients with ectasia (25%) had progression three years post-CXL, and the difference between both groups remained statistically significant(p-value 0.027). Conclusion Eyes with post-LASIK ectasia seem to be less responsive to CXL than KC.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>34917434</pmid><doi>10.7759/cureus.19552</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Contact lenses Cornea Laboratories Ophthalmology Patients Statistical analysis Topography Variables Vitamin B |
| title | Corneal Cross-Linking for Keratoconus and Post-LASIK Ectasia and Failure Rate: A 3 Years Follow-Up Study |
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