Antioxidative and Anti-Inflammatory Effects of Lactobacillus plantarum ZS62 on Alcohol-Induced Subacute Hepatic Damage
Lactobacillus plantarum ZS62 is a newly isolated strain from naturally fermented yogurt that might offer some beneficial effects in the setting of alcohol-induced subacute liver injury. The liver-protective effect of L. plantarum ZS62 was investigated by gavage feeding of mice with this Lactobacillu...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.7337988-7337988 |
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| creator | Gan, Yi Chen, Xiufeng Yi, Ruokun Zhao, Xin |
| description | Lactobacillus plantarum ZS62 is a newly isolated strain from naturally fermented yogurt that might offer some beneficial effects in the setting of alcohol-induced subacute liver injury. The liver-protective effect of L. plantarum ZS62 was investigated by gavage feeding of mice with this Lactobacillus strain (1×109 CFU/kg BW) before alcohol administration daily for 7 days. We then compared hepatic morphology, liver function indexes, liver lipid levels, inflammation, oxidative stress levels, and mRNA expression of oxidative metabolism- and inflammation-related genes in mice that had been pretreated with Lactobacillus plantarum versus control mice that had not been pretreated. Our results showed that L. plantarum ZS62 attenuated alcohol-induced weight loss; prevented morphological changes in hepatocytes; reduced markers of liver damage including aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), hyaluronidase (HAase), precollagen III (PC III), and inflammatory cytokines; and enhanced the antioxidative status. L. plantarum ZS62 also significantly downregulated inflammation-related genes and upregulated lipid- and oxidative-metabolism genes. Thus, Lactobacillus plantarum pretreatment appears to confer hepatic protection by reducing inflammation and enhancing antioxidative capacity. The protective effect of L. plantarum ZS62 was even better than that of a commonly used commercial lactic acid bacteria (Lactobacillus delbrueckii subsp. Bulgaricus). The L. plantarum ZS62 might be a potentially beneficial prophylactic treatment for people who frequently drink alcoholic beverages. |
| doi_str_mv | 10.1155/2021/7337988 |
| format | Article |
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The liver-protective effect of L. plantarum ZS62 was investigated by gavage feeding of mice with this Lactobacillus strain (1×109 CFU/kg BW) before alcohol administration daily for 7 days. We then compared hepatic morphology, liver function indexes, liver lipid levels, inflammation, oxidative stress levels, and mRNA expression of oxidative metabolism- and inflammation-related genes in mice that had been pretreated with Lactobacillus plantarum versus control mice that had not been pretreated. Our results showed that L. plantarum ZS62 attenuated alcohol-induced weight loss; prevented morphological changes in hepatocytes; reduced markers of liver damage including aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), hyaluronidase (HAase), precollagen III (PC III), and inflammatory cytokines; and enhanced the antioxidative status. L. plantarum ZS62 also significantly downregulated inflammation-related genes and upregulated lipid- and oxidative-metabolism genes. Thus, Lactobacillus plantarum pretreatment appears to confer hepatic protection by reducing inflammation and enhancing antioxidative capacity. The protective effect of L. plantarum ZS62 was even better than that of a commonly used commercial lactic acid bacteria (Lactobacillus delbrueckii subsp. Bulgaricus). The L. plantarum ZS62 might be a potentially beneficial prophylactic treatment for people who frequently drink alcoholic beverages.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2021/7337988</identifier><identifier>PMID: 34912498</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Alcohol ; Animals ; Anti-Inflammatory Agents - pharmacology ; Antioxidants - pharmacology ; Bioengineering ; Central Nervous System Depressants - toxicity ; Dehydrogenases ; Enzymes ; Ethanol - toxicity ; Gene expression ; Inflammation ; Inflammation - drug therapy ; Inflammation - etiology ; Inflammation - metabolism ; Inflammation - pathology ; Kinases ; Lactobacillus plantarum - chemistry ; Liver ; Liver Diseases, Alcoholic - etiology ; Liver Diseases, Alcoholic - metabolism ; Liver Diseases, Alcoholic - pathology ; Liver Diseases, Alcoholic - prevention & control ; Male ; Males ; Metabolism ; Mice ; Morphology ; Oxidative Stress ; Probiotics ; Probiotics - pharmacology ; Tumor necrosis factor-TNF</subject><ispartof>Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.7337988-7337988</ispartof><rights>Copyright © 2021 Yi Gan et al.</rights><rights>Copyright © 2021 Yi Gan et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Yi Gan et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3638-89988c7a53a621a981b8b044306769005ac84bd9c88b59d0e208c9aaa14869ea3</citedby><cites>FETCH-LOGICAL-c3638-89988c7a53a621a981b8b044306769005ac84bd9c88b59d0e208c9aaa14869ea3</cites><orcidid>0000-0001-9798-7865</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668337/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668337/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34912498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mendoza-Núñez, Víctor M.</contributor><contributor>Víctor M Mendoza-Núñez</contributor><creatorcontrib>Gan, Yi</creatorcontrib><creatorcontrib>Chen, Xiufeng</creatorcontrib><creatorcontrib>Yi, Ruokun</creatorcontrib><creatorcontrib>Zhao, Xin</creatorcontrib><title>Antioxidative and Anti-Inflammatory Effects of Lactobacillus plantarum ZS62 on Alcohol-Induced Subacute Hepatic Damage</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Lactobacillus plantarum ZS62 is a newly isolated strain from naturally fermented yogurt that might offer some beneficial effects in the setting of alcohol-induced subacute liver injury. The liver-protective effect of L. plantarum ZS62 was investigated by gavage feeding of mice with this Lactobacillus strain (1×109 CFU/kg BW) before alcohol administration daily for 7 days. We then compared hepatic morphology, liver function indexes, liver lipid levels, inflammation, oxidative stress levels, and mRNA expression of oxidative metabolism- and inflammation-related genes in mice that had been pretreated with Lactobacillus plantarum versus control mice that had not been pretreated. Our results showed that L. plantarum ZS62 attenuated alcohol-induced weight loss; prevented morphological changes in hepatocytes; reduced markers of liver damage including aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), hyaluronidase (HAase), precollagen III (PC III), and inflammatory cytokines; and enhanced the antioxidative status. L. plantarum ZS62 also significantly downregulated inflammation-related genes and upregulated lipid- and oxidative-metabolism genes. Thus, Lactobacillus plantarum pretreatment appears to confer hepatic protection by reducing inflammation and enhancing antioxidative capacity. The protective effect of L. plantarum ZS62 was even better than that of a commonly used commercial lactic acid bacteria (Lactobacillus delbrueckii subsp. Bulgaricus). 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Chen, Xiufeng ; Yi, Ruokun ; Zhao, Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3638-89988c7a53a621a981b8b044306769005ac84bd9c88b59d0e208c9aaa14869ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alcohol</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Bioengineering</topic><topic>Central Nervous System Depressants - toxicity</topic><topic>Dehydrogenases</topic><topic>Enzymes</topic><topic>Ethanol - toxicity</topic><topic>Gene expression</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - etiology</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Kinases</topic><topic>Lactobacillus plantarum - chemistry</topic><topic>Liver</topic><topic>Liver Diseases, Alcoholic - etiology</topic><topic>Liver Diseases, Alcoholic - metabolism</topic><topic>Liver Diseases, Alcoholic - pathology</topic><topic>Liver Diseases, Alcoholic - prevention & control</topic><topic>Male</topic><topic>Males</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Morphology</topic><topic>Oxidative Stress</topic><topic>Probiotics</topic><topic>Probiotics - pharmacology</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gan, Yi</creatorcontrib><creatorcontrib>Chen, Xiufeng</creatorcontrib><creatorcontrib>Yi, Ruokun</creatorcontrib><creatorcontrib>Zhao, Xin</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gan, Yi</au><au>Chen, Xiufeng</au><au>Yi, Ruokun</au><au>Zhao, Xin</au><au>Mendoza-Núñez, Víctor M.</au><au>Víctor M Mendoza-Núñez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidative and Anti-Inflammatory Effects of Lactobacillus plantarum ZS62 on Alcohol-Induced Subacute Hepatic Damage</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><issue>1</issue><spage>7337988</spage><epage>7337988</epage><pages>7337988-7337988</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Lactobacillus plantarum ZS62 is a newly isolated strain from naturally fermented yogurt that might offer some beneficial effects in the setting of alcohol-induced subacute liver injury. The liver-protective effect of L. plantarum ZS62 was investigated by gavage feeding of mice with this Lactobacillus strain (1×109 CFU/kg BW) before alcohol administration daily for 7 days. We then compared hepatic morphology, liver function indexes, liver lipid levels, inflammation, oxidative stress levels, and mRNA expression of oxidative metabolism- and inflammation-related genes in mice that had been pretreated with Lactobacillus plantarum versus control mice that had not been pretreated. Our results showed that L. plantarum ZS62 attenuated alcohol-induced weight loss; prevented morphological changes in hepatocytes; reduced markers of liver damage including aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), hyaluronidase (HAase), precollagen III (PC III), and inflammatory cytokines; and enhanced the antioxidative status. L. plantarum ZS62 also significantly downregulated inflammation-related genes and upregulated lipid- and oxidative-metabolism genes. Thus, Lactobacillus plantarum pretreatment appears to confer hepatic protection by reducing inflammation and enhancing antioxidative capacity. The protective effect of L. plantarum ZS62 was even better than that of a commonly used commercial lactic acid bacteria (Lactobacillus delbrueckii subsp. Bulgaricus). The L. plantarum ZS62 might be a potentially beneficial prophylactic treatment for people who frequently drink alcoholic beverages.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34912498</pmid><doi>10.1155/2021/7337988</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-9798-7865</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Bioengineering Central Nervous System Depressants - toxicity Dehydrogenases Enzymes Ethanol - toxicity Gene expression Inflammation Inflammation - drug therapy Inflammation - etiology Inflammation - metabolism Inflammation - pathology Kinases Lactobacillus plantarum - chemistry Liver Liver Diseases, Alcoholic - etiology Liver Diseases, Alcoholic - metabolism Liver Diseases, Alcoholic - pathology Liver Diseases, Alcoholic - prevention & control Male Males Metabolism Mice Morphology Oxidative Stress Probiotics Probiotics - pharmacology Tumor necrosis factor-TNF |
| title | Antioxidative and Anti-Inflammatory Effects of Lactobacillus plantarum ZS62 on Alcohol-Induced Subacute Hepatic Damage |
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