Safety of Five Tuina Manipulations in Rats with Deep Vein Thrombosis
Objective. To study the effects of five tuina manipulations in rats with deep vein thrombosis (DVT) and to explore how to safely perform tuina in the treatment of thrombotic diseases. Methods. Seventy-two male Sprague-Dawley (SD) rats were randomly divided into the model, pointing manipulation, pluc...
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| description | Objective. To study the effects of five tuina manipulations in rats with deep vein thrombosis (DVT) and to explore how to safely perform tuina in the treatment of thrombotic diseases. Methods. Seventy-two male Sprague-Dawley (SD) rats were randomly divided into the model, pointing manipulation, plucking manipulation, kneading manipulation, pushing manipulation, and pulling manipulation groups (n = 12). DVT model was established by incomplete ligation. The tuina intervention was started on the next day after modeling and applied once a day 10 times by the manipulation simulators. On the 3rd and 10th days after intervention, respectively, the effects of tuina on thrombosis were evaluated based on thrombus elasticity, blood coagulation, fibrinolytic function and blood rheology with the ultrasound elastography, four coagulation tests, enzyme linked immunosorbent assay (ELISA), and hemorheology tests. Results. In the pointing manipulation group, the strain rate ratio, 6-ketoprostaglandin F1α (6-Keto-PGF1α), and high shear rate were decreased, and the thromboxane B2 (TXB2) content was increased (P |
| doi_str_mv | 10.1155/2021/6897124 |
| format | Article |
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Sahab ; Md Sahab Uddin</contributor><creatorcontrib>Zhou, Ying ; Zhang, Yumo ; Zhang, Xiaoyan ; Chen, Zhuo ; Dong, Jian ; Yang, Chao ; Lv, Taotao ; Yu, Tianyuan ; Lu, Mengqian ; Uddin, Md. Sahab ; Md Sahab Uddin</creatorcontrib><description><![CDATA[Objective. To study the effects of five tuina manipulations in rats with deep vein thrombosis (DVT) and to explore how to safely perform tuina in the treatment of thrombotic diseases. Methods. Seventy-two male Sprague-Dawley (SD) rats were randomly divided into the model, pointing manipulation, plucking manipulation, kneading manipulation, pushing manipulation, and pulling manipulation groups (n = 12). DVT model was established by incomplete ligation. The tuina intervention was started on the next day after modeling and applied once a day 10 times by the manipulation simulators. On the 3rd and 10th days after intervention, respectively, the effects of tuina on thrombosis were evaluated based on thrombus elasticity, blood coagulation, fibrinolytic function and blood rheology with the ultrasound elastography, four coagulation tests, enzyme linked immunosorbent assay (ELISA), and hemorheology tests. Results. In the pointing manipulation group, the strain rate ratio, 6-ketoprostaglandin F1α (6-Keto-PGF1α), and high shear rate were decreased, and the thromboxane B2 (TXB2) content was increased (P<0.05). In the plucking manipulation group, the D-dimer and 6-Keto-PGF1α contents were increased, prothrombin time (PT) was shortened, and activated partial thromboplastin time (APTT) was activated, and the high shear rate and plasma viscosity were decreased (P<0.05). In the kneading manipulation group, APTT was shortened, and 6-Keto-PGF1α, high shear rate, and plasma viscosity were decreased (P<0.05). In the pushing manipulation group, the strain rate ratio, low shear rate, and high shear rate were all decreased (P<0.05). In the pulling manipulation group, both the strain rate ratio and the low shear rate were decreased (P<0.05). The 6-Keto-PGF1α changes on the 3rd and 10th days after intervention were opposite in the pushing manipulation group and the pulling manipulation group (P<0.05). Conclusion. The pointing, pushing, and pulling manipulations seem to be safe in the early period of thrombosis, but the risk is likely to be elevated as the treatment course of intervention increases. The plucking and kneading manipulations potentially have certain risks in the treatment of DVT in rats.]]></description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2021/6897124</identifier><identifier>PMID: 34912466</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Abdomen ; Blood clots ; Blood coagulation ; Chinese medicine ; Enzyme-linked immunosorbent assay ; Enzymes ; Fibrin ; Intervention ; Pain ; Plasma ; Prothrombin ; Pulmonary embolisms ; Rheology ; Statistical analysis ; Thromboplastin ; Thrombosis ; Ultrasonic imaging ; Veins & arteries</subject><ispartof>Evidence-based complementary and alternative medicine, 2021, Vol.2021, p.6897124-10</ispartof><rights>Copyright © 2021 Ying Zhou et al.</rights><rights>Copyright © 2021 Ying Zhou et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Ying Zhou et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c405t-5d9802a5e972f691c4cbebe0c597a5ea06a20f460a7a07fc06a29a1f1c2e5f63</cites><orcidid>0000-0003-2089-3101 ; 0000-0002-6625-5474</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668308/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668308/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34912466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Uddin, Md. Sahab</contributor><contributor>Md Sahab Uddin</contributor><creatorcontrib>Zhou, Ying</creatorcontrib><creatorcontrib>Zhang, Yumo</creatorcontrib><creatorcontrib>Zhang, Xiaoyan</creatorcontrib><creatorcontrib>Chen, Zhuo</creatorcontrib><creatorcontrib>Dong, Jian</creatorcontrib><creatorcontrib>Yang, Chao</creatorcontrib><creatorcontrib>Lv, Taotao</creatorcontrib><creatorcontrib>Yu, Tianyuan</creatorcontrib><creatorcontrib>Lu, Mengqian</creatorcontrib><title>Safety of Five Tuina Manipulations in Rats with Deep Vein Thrombosis</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description><![CDATA[Objective. To study the effects of five tuina manipulations in rats with deep vein thrombosis (DVT) and to explore how to safely perform tuina in the treatment of thrombotic diseases. Methods. Seventy-two male Sprague-Dawley (SD) rats were randomly divided into the model, pointing manipulation, plucking manipulation, kneading manipulation, pushing manipulation, and pulling manipulation groups (n = 12). DVT model was established by incomplete ligation. The tuina intervention was started on the next day after modeling and applied once a day 10 times by the manipulation simulators. On the 3rd and 10th days after intervention, respectively, the effects of tuina on thrombosis were evaluated based on thrombus elasticity, blood coagulation, fibrinolytic function and blood rheology with the ultrasound elastography, four coagulation tests, enzyme linked immunosorbent assay (ELISA), and hemorheology tests. Results. In the pointing manipulation group, the strain rate ratio, 6-ketoprostaglandin F1α (6-Keto-PGF1α), and high shear rate were decreased, and the thromboxane B2 (TXB2) content was increased (P<0.05). In the plucking manipulation group, the D-dimer and 6-Keto-PGF1α contents were increased, prothrombin time (PT) was shortened, and activated partial thromboplastin time (APTT) was activated, and the high shear rate and plasma viscosity were decreased (P<0.05). In the kneading manipulation group, APTT was shortened, and 6-Keto-PGF1α, high shear rate, and plasma viscosity were decreased (P<0.05). In the pushing manipulation group, the strain rate ratio, low shear rate, and high shear rate were all decreased (P<0.05). In the pulling manipulation group, both the strain rate ratio and the low shear rate were decreased (P<0.05). The 6-Keto-PGF1α changes on the 3rd and 10th days after intervention were opposite in the pushing manipulation group and the pulling manipulation group (P<0.05). Conclusion. The pointing, pushing, and pulling manipulations seem to be safe in the early period of thrombosis, but the risk is likely to be elevated as the treatment course of intervention increases. The plucking and kneading manipulations potentially have certain risks in the treatment of DVT in rats.]]></description><subject>Abdomen</subject><subject>Blood clots</subject><subject>Blood coagulation</subject><subject>Chinese medicine</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Fibrin</subject><subject>Intervention</subject><subject>Pain</subject><subject>Plasma</subject><subject>Prothrombin</subject><subject>Pulmonary embolisms</subject><subject>Rheology</subject><subject>Statistical analysis</subject><subject>Thromboplastin</subject><subject>Thrombosis</subject><subject>Ultrasonic imaging</subject><subject>Veins & arteries</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90c1LBCEYBnCJou9b5xC6BLWlzqjjJYi-oQhqiW7yrqutMavbOFP03-ey21IdOqmvPx6UB6EdSo4o5fyYEUaPRaUkZeUSWqeypL2SVdXyYi-f19BGSq-EMCWlXEVrRamyFmIdnT-Cs-0njg5f-neL-50PgO8g-ElXQ-tjSNgH_ABtwh--HeFzayf4yeZZf9TE8SAmn7bQioM62e35uon6lxf9s-ve7f3Vzdnpbc-UhLc9PlQVYcCtkswJRU1pBnZgieFK5ikQAYy4UhCQQKQz07MC6qhhljtRbKKTWeykG4zt0NjQNlDrSePH0HzqCF7_vgl-pF_iu66EqApS5YD9eUAT3zqbWj32ydi6hmBjlzQTlChaSMkz3ftDX2PXhPy7qaIFr7hkWR3OlGliSo11i8dQoqft6Gk7et5O5rs_P7DA33VkcDADIx-G8OH_j_sCQrCWwA</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Zhou, Ying</creator><creator>Zhang, Yumo</creator><creator>Zhang, Xiaoyan</creator><creator>Chen, Zhuo</creator><creator>Dong, Jian</creator><creator>Yang, Chao</creator><creator>Lv, Taotao</creator><creator>Yu, Tianyuan</creator><creator>Lu, Mengqian</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2089-3101</orcidid><orcidid>https://orcid.org/0000-0002-6625-5474</orcidid></search><sort><creationdate>2021</creationdate><title>Safety of Five Tuina Manipulations in Rats with Deep Vein Thrombosis</title><author>Zhou, Ying ; Zhang, Yumo ; Zhang, Xiaoyan ; Chen, Zhuo ; Dong, Jian ; Yang, Chao ; Lv, Taotao ; Yu, Tianyuan ; Lu, Mengqian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-5d9802a5e972f691c4cbebe0c597a5ea06a20f460a7a07fc06a29a1f1c2e5f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdomen</topic><topic>Blood clots</topic><topic>Blood coagulation</topic><topic>Chinese medicine</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Fibrin</topic><topic>Intervention</topic><topic>Pain</topic><topic>Plasma</topic><topic>Prothrombin</topic><topic>Pulmonary embolisms</topic><topic>Rheology</topic><topic>Statistical analysis</topic><topic>Thromboplastin</topic><topic>Thrombosis</topic><topic>Ultrasonic imaging</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Ying</creatorcontrib><creatorcontrib>Zhang, Yumo</creatorcontrib><creatorcontrib>Zhang, Xiaoyan</creatorcontrib><creatorcontrib>Chen, Zhuo</creatorcontrib><creatorcontrib>Dong, Jian</creatorcontrib><creatorcontrib>Yang, Chao</creatorcontrib><creatorcontrib>Lv, Taotao</creatorcontrib><creatorcontrib>Yu, Tianyuan</creatorcontrib><creatorcontrib>Lu, Mengqian</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Ying</au><au>Zhang, Yumo</au><au>Zhang, Xiaoyan</au><au>Chen, Zhuo</au><au>Dong, Jian</au><au>Yang, Chao</au><au>Lv, Taotao</au><au>Yu, Tianyuan</au><au>Lu, Mengqian</au><au>Uddin, Md. Sahab</au><au>Md Sahab Uddin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety of Five Tuina Manipulations in Rats with Deep Vein Thrombosis</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>6897124</spage><epage>10</epage><pages>6897124-10</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract><![CDATA[Objective. To study the effects of five tuina manipulations in rats with deep vein thrombosis (DVT) and to explore how to safely perform tuina in the treatment of thrombotic diseases. Methods. Seventy-two male Sprague-Dawley (SD) rats were randomly divided into the model, pointing manipulation, plucking manipulation, kneading manipulation, pushing manipulation, and pulling manipulation groups (n = 12). DVT model was established by incomplete ligation. The tuina intervention was started on the next day after modeling and applied once a day 10 times by the manipulation simulators. On the 3rd and 10th days after intervention, respectively, the effects of tuina on thrombosis were evaluated based on thrombus elasticity, blood coagulation, fibrinolytic function and blood rheology with the ultrasound elastography, four coagulation tests, enzyme linked immunosorbent assay (ELISA), and hemorheology tests. Results. In the pointing manipulation group, the strain rate ratio, 6-ketoprostaglandin F1α (6-Keto-PGF1α), and high shear rate were decreased, and the thromboxane B2 (TXB2) content was increased (P<0.05). In the plucking manipulation group, the D-dimer and 6-Keto-PGF1α contents were increased, prothrombin time (PT) was shortened, and activated partial thromboplastin time (APTT) was activated, and the high shear rate and plasma viscosity were decreased (P<0.05). In the kneading manipulation group, APTT was shortened, and 6-Keto-PGF1α, high shear rate, and plasma viscosity were decreased (P<0.05). In the pushing manipulation group, the strain rate ratio, low shear rate, and high shear rate were all decreased (P<0.05). In the pulling manipulation group, both the strain rate ratio and the low shear rate were decreased (P<0.05). The 6-Keto-PGF1α changes on the 3rd and 10th days after intervention were opposite in the pushing manipulation group and the pulling manipulation group (P<0.05). Conclusion. The pointing, pushing, and pulling manipulations seem to be safe in the early period of thrombosis, but the risk is likely to be elevated as the treatment course of intervention increases. The plucking and kneading manipulations potentially have certain risks in the treatment of DVT in rats.]]></abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34912466</pmid><doi>10.1155/2021/6897124</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2089-3101</orcidid><orcidid>https://orcid.org/0000-0002-6625-5474</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Abdomen Blood clots Blood coagulation Chinese medicine Enzyme-linked immunosorbent assay Enzymes Fibrin Intervention Pain Plasma Prothrombin Pulmonary embolisms Rheology Statistical analysis Thromboplastin Thrombosis Ultrasonic imaging Veins & arteries |
| title | Safety of Five Tuina Manipulations in Rats with Deep Vein Thrombosis |
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