Runx3 regulates iron metabolism via modulation of BMP signalling

Objectives Runx3, a member of the Runx family of transcription factors, has been studied as a tumour suppressor and key player of organ development. In a previous study, we reported differentiation failure and excessive angiogenesis in the liver of Runx3 knock‐out (KO) mice. Here, we examined a func...

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Veröffentlicht in:	Cell proliferation 2021-12, Vol.54 (12), p.e13138-n/a
Hauptverfasser:	Kim, Hyun‐Yi, Lee, Jong‐Min, Lee, You‐Soub, Li, Shujin, Lee, Seung‐Jun, Bae, Suk‐Chul, Jung, Han‐Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Angiogenesis Animal tissues Animals Antibodies Antigens Biotechnology Bmp pathway Bmp6 Bone Morphogenetic Protein 6 - genetics Bone Morphogenetic Protein 6 - metabolism Bone morphogenetic proteins Cell signaling Core Binding Factor Alpha 3 Subunit - genetics Core Binding Factor Alpha 3 Subunit - metabolism Gene expression Gene sequencing Genomics Hep G2 Cells Hepatocellular carcinoma Hepatocytes Hepatocytes - metabolism Hepcidin Humans Iron Kinases Liver Liver - metabolism liver iron metabolism Metabolism Mice Mice, Knockout Original Plasma Proteins Runx3 Runx3 protein Signal Transduction Signaling siRNA Software Transcription factors Transcriptomes Tumor suppressor genes Tumors
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