CD1-Restricted T Cells in Inflammatory Skin Diseases

CD1-Restricted T Cells in Inflammatory Skin Diseases

Autoimmunity results from the breaking of immune tolerance, leading to inflammation and pathology. Although well studied in the conventional T-cell field, the role of nonconventional T cells in autoimmunity is less understood. CD1-restricted T cells recognize lipid antigens rather than peptide antig...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of investigative dermatology 2022-03, Vol.142 (3), p.768-773
Hauptverfasser: Genardi, Samantha, Morgun, Eva, Wang, Chyung-Ru
Format: Artikel
Sprache:eng
Schlagworte:
Antigen Presentation
Antigens, CD1
Autoimmunity
Dermatitis - immunology
Immune Tolerance
T-Lymphocytes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Autoimmunity results from the breaking of immune tolerance, leading to inflammation and pathology. Although well studied in the conventional T-cell field, the role of nonconventional T cells in autoimmunity is less understood. CD1-restricted T cells recognize lipid antigens rather than peptide antigens and have been implicated in various autoimmune skin conditions, including psoriasis and atopic dermatitis. In this review, we will discuss the self-lipids that CD1-restricted T cells recognize and how these T cells become aberrantly regulated in pathogenic skin conditions.
ISSN:0022-202X
1523-1747
1523-1747
DOI:10.1016/j.jid.2021.03.033