Candida Endophthalmitis Treated Successfully With Isavuconazole: A Case Report
Abstract Candida endophthalmitis is a serious complication of candidemia. Diagnosis requires identification of ocular lesions on dilated fundoscopy, aided by isolation of the organism from blood and/or vitreous humor. However, the initial ophthalmological examination may be negative in some cases. E...
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| Veröffentlicht in: | Open Forum Infectious Diseases 2021-12, Vol.8 (12), p.ofab516 |
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| creator | Sng, Edwin Chong Yu Tan, Ai Ling Zhou, Peijun Yvonne Tan, Tira J Waduthantri, Samanthila Chee, Soon-Phaik Tan, Ban Hock |
| description | Abstract
Candida endophthalmitis is a serious complication of candidemia. Diagnosis requires identification of ocular lesions on dilated fundoscopy, aided by isolation of the organism from blood and/or vitreous humor. However, the initial ophthalmological examination may be negative in some cases. Experience with isavuconazole for the treatment of Candida endophthalmitis is limited. We present a case of a 65-year-old woman with metastatic breast cancer on chemotherapy who developed Candida dubliniensis endophthalmitis with initial negative ophthalmological examination. She was treated with vitrectomy and 6 weeks of oral fluconazole. Despite vitrectomy and culture-directed antifungal treatment, management was complicated by lack of response to fluconazole and intolerance to other antifungals, necessitating the use of isavuconazole, which proved efficacious. |
| doi_str_mv | 10.1093/ofid/ofab516 |
| format | Article |
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Candida endophthalmitis is a serious complication of candidemia. Diagnosis requires identification of ocular lesions on dilated fundoscopy, aided by isolation of the organism from blood and/or vitreous humor. However, the initial ophthalmological examination may be negative in some cases. Experience with isavuconazole for the treatment of Candida endophthalmitis is limited. We present a case of a 65-year-old woman with metastatic breast cancer on chemotherapy who developed Candida dubliniensis endophthalmitis with initial negative ophthalmological examination. She was treated with vitrectomy and 6 weeks of oral fluconazole. Despite vitrectomy and culture-directed antifungal treatment, management was complicated by lack of response to fluconazole and intolerance to other antifungals, necessitating the use of isavuconazole, which proved efficacious.</description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofab516</identifier><identifier>PMID: 34909437</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Anidulafungin ; Cancer ; Caspofungin ; Chemotherapy ; Endophthalmitis ; Fluconazole ; Novel ID Cases</subject><ispartof>Open Forum Infectious Diseases, 2021-12, Vol.8 (12), p.ofab516</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-b2f1a8843f82aab2103711a62c5f4968285d08c4dff2589f497b186ce3af7df53</citedby><cites>FETCH-LOGICAL-c450t-b2f1a8843f82aab2103711a62c5f4968285d08c4dff2589f497b186ce3af7df53</cites><orcidid>0000-0002-1458-9456 ; 0000-0001-6522-2614</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664687/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664687/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1604,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34909437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sng, Edwin Chong Yu</creatorcontrib><creatorcontrib>Tan, Ai Ling</creatorcontrib><creatorcontrib>Zhou, Peijun Yvonne</creatorcontrib><creatorcontrib>Tan, Tira J</creatorcontrib><creatorcontrib>Waduthantri, Samanthila</creatorcontrib><creatorcontrib>Chee, Soon-Phaik</creatorcontrib><creatorcontrib>Tan, Ban Hock</creatorcontrib><title>Candida Endophthalmitis Treated Successfully With Isavuconazole: A Case Report</title><title>Open Forum Infectious Diseases</title><addtitle>Open Forum Infect Dis</addtitle><description>Abstract
Candida endophthalmitis is a serious complication of candidemia. Diagnosis requires identification of ocular lesions on dilated fundoscopy, aided by isolation of the organism from blood and/or vitreous humor. However, the initial ophthalmological examination may be negative in some cases. Experience with isavuconazole for the treatment of Candida endophthalmitis is limited. We present a case of a 65-year-old woman with metastatic breast cancer on chemotherapy who developed Candida dubliniensis endophthalmitis with initial negative ophthalmological examination. She was treated with vitrectomy and 6 weeks of oral fluconazole. Despite vitrectomy and culture-directed antifungal treatment, management was complicated by lack of response to fluconazole and intolerance to other antifungals, necessitating the use of isavuconazole, which proved efficacious.</description><subject>Anidulafungin</subject><subject>Cancer</subject><subject>Caspofungin</subject><subject>Chemotherapy</subject><subject>Endophthalmitis</subject><subject>Fluconazole</subject><subject>Novel ID Cases</subject><issn>2328-8957</issn><issn>2328-8957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kctLxDAQxoMoKqs3z9KbF1eTtGlSD8JSfMGi4AOPYZqHG-k2pWkX1r_eLLvKepHAZJj85ksmH0InBF8QXKSX3jodA1SM5DvokKZUjEXB-O5WfoCOQ_jEGBOCGebFPjpIswIXWcoP0WMJjXYakptG-3bWz6Ceu96F5LUz0BudvAxKmRDsUNfL5N31s-QhwGJQvoEvX5urZJKUEEzybFrf9Udoz0IdzPFmH6G325vX8n48fbp7KCfTscoY7scVtQSEyFIrKEBFCU45IZBTxWxW5IIKprFQmbaWMlHEGq-IyJVJwXJtWTpC12vddqjmRivT9B3Usu3cHLql9ODk35PGzeSHX0iR51kueBS4WAt8QG2ka6yPmIpLm7mLwxnrYn3COSs4I5TGhvN1g-p8CJ2xv5cRLFdeyJUXcuNFxE-3H_gL__x8BM7WgB_a_6W-AZeZlQI</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Sng, Edwin Chong Yu</creator><creator>Tan, Ai Ling</creator><creator>Zhou, Peijun Yvonne</creator><creator>Tan, Tira J</creator><creator>Waduthantri, Samanthila</creator><creator>Chee, Soon-Phaik</creator><creator>Tan, Ban Hock</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1458-9456</orcidid><orcidid>https://orcid.org/0000-0001-6522-2614</orcidid></search><sort><creationdate>20211201</creationdate><title>Candida Endophthalmitis Treated Successfully With Isavuconazole: A Case Report</title><author>Sng, Edwin Chong Yu ; Tan, Ai Ling ; Zhou, Peijun Yvonne ; Tan, Tira J ; Waduthantri, Samanthila ; Chee, Soon-Phaik ; Tan, Ban Hock</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-b2f1a8843f82aab2103711a62c5f4968285d08c4dff2589f497b186ce3af7df53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anidulafungin</topic><topic>Cancer</topic><topic>Caspofungin</topic><topic>Chemotherapy</topic><topic>Endophthalmitis</topic><topic>Fluconazole</topic><topic>Novel ID Cases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sng, Edwin Chong Yu</creatorcontrib><creatorcontrib>Tan, Ai Ling</creatorcontrib><creatorcontrib>Zhou, Peijun Yvonne</creatorcontrib><creatorcontrib>Tan, Tira J</creatorcontrib><creatorcontrib>Waduthantri, Samanthila</creatorcontrib><creatorcontrib>Chee, Soon-Phaik</creatorcontrib><creatorcontrib>Tan, Ban Hock</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Open Forum Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sng, Edwin Chong Yu</au><au>Tan, Ai Ling</au><au>Zhou, Peijun Yvonne</au><au>Tan, Tira J</au><au>Waduthantri, Samanthila</au><au>Chee, Soon-Phaik</au><au>Tan, Ban Hock</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Candida Endophthalmitis Treated Successfully With Isavuconazole: A Case Report</atitle><jtitle>Open Forum Infectious Diseases</jtitle><addtitle>Open Forum Infect Dis</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>8</volume><issue>12</issue><spage>ofab516</spage><pages>ofab516-</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract>Abstract
Candida endophthalmitis is a serious complication of candidemia. Diagnosis requires identification of ocular lesions on dilated fundoscopy, aided by isolation of the organism from blood and/or vitreous humor. However, the initial ophthalmological examination may be negative in some cases. Experience with isavuconazole for the treatment of Candida endophthalmitis is limited. We present a case of a 65-year-old woman with metastatic breast cancer on chemotherapy who developed Candida dubliniensis endophthalmitis with initial negative ophthalmological examination. She was treated with vitrectomy and 6 weeks of oral fluconazole. Despite vitrectomy and culture-directed antifungal treatment, management was complicated by lack of response to fluconazole and intolerance to other antifungals, necessitating the use of isavuconazole, which proved efficacious.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>34909437</pmid><doi>10.1093/ofid/ofab516</doi><orcidid>https://orcid.org/0000-0002-1458-9456</orcidid><orcidid>https://orcid.org/0000-0001-6522-2614</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anidulafungin Cancer Caspofungin Chemotherapy Endophthalmitis Fluconazole Novel ID Cases |
| title | Candida Endophthalmitis Treated Successfully With Isavuconazole: A Case Report |
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