Mangiferin Inhibits PDGF-BB-Induced Proliferation and Migration of Rat Vascular Smooth Muscle Cells and Alleviates Neointimal Formation in Mice through the AMPK/Drp1 Axis

Mangiferin is a naturally occurring xanthone C-glycoside that is widely found in various plants. Previous studies have reported that mangiferin inhibits tumor cell proliferation and migration. Excessive proliferation and migration of vascular smooth muscle cells (SMCs) is associated with neointimal...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.3119953-3119953
Hauptverfasser:	Wu, Qi, Chen, Yuanyang, Wang, Zhiwei, Cai, Xin, Che, Yanjia, Zheng, Sihao, Yuan, Shun, Zhong, Xiaohan
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Antibodies Becaplermin - pharmacology Biotechnology Cardiovascular disease Carotid Arteries - pathology Cell culture Cell Dedifferentiation - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Coronary vessels Dynamins - metabolism Flow cytometry Hyperplasia Hyperplasia - metabolism Hyperplasia - pathology Kinases Laboratory animals Male Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Medical prognosis Mice Mice, Inbred C57BL Mitochondria Mitochondrial Dynamics - drug effects Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Phosphorylation Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Rats Reactive Oxygen Species - metabolism Smooth muscle Vein & artery diseases Xanthones - pharmacology
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