Absorption and Clearance of Pharmaceutical Aerosols in the Human Nose: Effects of Nasal Spray Suspension Particle Size and Properties

Purpose The objective of this study was to use a recently developed nasal dissolution, absorption, and clearance (DAC) model to evaluate the extent to which suspended drug particle size influences nasal epithelial drug absorption for a spray product. Methods Computational fluid dynamics (CFD) simula...

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Veröffentlicht in:	Pharmaceutical research 2016-04, Vol.33 (4), p.909-921
Hauptverfasser:	Rygg, Alex, Hindle, Michael, Longest, P. Worth
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Aerosols - administration & dosage Aerosols - pharmacokinetics Analysis Anti-Allergic Agents - administration & dosage Anti-Allergic Agents - pharmacokinetics Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Computer Simulation Drug delivery systems Drugs Drugs and athletes Humans Medical Law Models, Biological Mometasone Mometasone Furoate - administration & dosage Mometasone Furoate - pharmacokinetics Nasal Cavity - metabolism Nasal Sprays Nose Particle Size Pharmacology Pharmacology/Toxicology Pharmacy Research Paper Respiratory agents Respiratory Mucosa - metabolism Solubility Vehicles
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