Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss
Aims/hypothesis Type 2 diabetes confers a greater relative increase in CVD risk in women compared with men. We examined sex differences in intraorgan fat and hepatic VLDL1-triacylglycerol (VLDL1-TG) export before and after major dietary weight loss. Methods A group with type 2 diabetes ( n = 64, 30...
Gespeichert in:
| Veröffentlicht in: | Diabetologia 2022-01, Vol.65 (1), p.226-233 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 233 |
|---|---|
| container_issue | 1 |
| container_start_page | 226 |
| container_title | Diabetologia |
| container_volume | 65 |
| creator | Jesuthasan, Aaron Zhyzhneuskaya, Sviatlana Peters, Carl Barnes, Alison C. Hollingsworth, Kieren G. Sattar, Naveed Lean, Michael E. J. Taylor, Roy Al-Mrabeh, Ahmad H. |
| description | Aims/hypothesis
Type 2 diabetes confers a greater relative increase in CVD risk in women compared with men. We examined sex differences in intraorgan fat and hepatic VLDL1-triacylglycerol (VLDL1-TG) export before and after major dietary weight loss.
Methods
A group with type 2 diabetes (
n
= 64, 30 male/34 female) and a group of healthy individuals (
n
= 25, 13 male/12 female) were studied. Intraorgan and visceral fat were quantified by magnetic resonance and VLDL1-TG export by intralipid infusion techniques.
Results
Triacylglycerol content of the liver and pancreas was elevated in people with diabetes with no sex differences (liver 16.4% [9.3–25.0%] in women vs 11.9% [7.0–23.1%] in men,
p
= 0.57, and pancreas 8.3 ± 0.5% vs 8.5 ± 0.4%,
p
= 0.83, respectively). In the absence of diabetes, fat levels in both organs were lower in women than men (1.0% [0.9–1.7%] vs 4.5% [1.9–8.0%],
p
= 0.005, and 4.7 ± 0.4% vs 7.6 ± 0.5%,
p |
| doi_str_mv | 10.1007/s00125-021-05583-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8660759</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2608260838</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-6d95ecdf403a6ecee132f2d0e5fefdd561bcf74a8e825941763337e76cb66a633</originalsourceid><addsrcrecordid>eNp9Uk2LFDEQDaK44-of8CABL15a89XpHg_CsvgFCx5U8BbSSWUmS7rTJj2j-4_8mdbsrOvHQUgIxXv16lWlCHnM2XPOWPeiMsZF2zDBG9a2vWzUHbLiSoqGKdHfJasD3vBefzkhD2q9ZIzJVun75EQq3Xa8Fyvy4yN8pz6GAAUmB5XGCc9SbC4bO9FgF5pgD6lSO3m6hdku0dEU5-jpCIsdcop1fEnjOKfoEMxTpSEX6mzxMe9tdbtkC2batGyvRQqMsVYk0hzocjUDFejADrBgeRsWKBiidLmi3yButugg1_qQ3As2VXh0856Sz29efzp_11x8ePv-_OyicapTS6P9ugXng2LSanAAXIogPIM2QPC-1XxwoVO2h160a8U7LaXsoNNu0NpicEpeHXXn3TCCd3AYRjJziSM6MtlG8zcyxa3Z5L3ptWZdu0aBZzcCJX_dQV0MtusgJTtB3lUj8Kek6JTWSH36D_Uy78qE7RmhWX-4skeWOLJcwTkUCLdmODOHRTDHRTC4COZ6EYzCpCd_tnGb8uvnkSCPhIrQtIHyu_Z_ZH8CEELDbg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2608260838</pqid></control><display><type>article</type><title>Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss</title><source>MEDLINE</source><source>SpringerLink</source><creator>Jesuthasan, Aaron ; Zhyzhneuskaya, Sviatlana ; Peters, Carl ; Barnes, Alison C. ; Hollingsworth, Kieren G. ; Sattar, Naveed ; Lean, Michael E. J. ; Taylor, Roy ; Al-Mrabeh, Ahmad H.</creator><creatorcontrib>Jesuthasan, Aaron ; Zhyzhneuskaya, Sviatlana ; Peters, Carl ; Barnes, Alison C. ; Hollingsworth, Kieren G. ; Sattar, Naveed ; Lean, Michael E. J. ; Taylor, Roy ; Al-Mrabeh, Ahmad H.</creatorcontrib><description>Aims/hypothesis
Type 2 diabetes confers a greater relative increase in CVD risk in women compared with men. We examined sex differences in intraorgan fat and hepatic VLDL1-triacylglycerol (VLDL1-TG) export before and after major dietary weight loss.
Methods
A group with type 2 diabetes (
n
= 64, 30 male/34 female) and a group of healthy individuals (
n
= 25, 13 male/12 female) were studied. Intraorgan and visceral fat were quantified by magnetic resonance and VLDL1-TG export by intralipid infusion techniques.
Results
Triacylglycerol content of the liver and pancreas was elevated in people with diabetes with no sex differences (liver 16.4% [9.3–25.0%] in women vs 11.9% [7.0–23.1%] in men,
p
= 0.57, and pancreas 8.3 ± 0.5% vs 8.5 ± 0.4%,
p
= 0.83, respectively). In the absence of diabetes, fat levels in both organs were lower in women than men (1.0% [0.9–1.7%] vs 4.5% [1.9–8.0%],
p
= 0.005, and 4.7 ± 0.4% vs 7.6 ± 0.5%,
p
< 0.0001, respectively). Women with diabetes had higher hepatic VLDL1-TG production rate and plasma VLDL1-TG than healthy women (559.3 ± 32.9 vs 403.2 ± 45.7 mg kg
−1
day
−1
,
p
= 0.01, and 0.45 [0.26–0.77] vs 0.25 [0.13–0.33] mmol/l,
p
= 0.02), whereas there were no differences in men (548.8 ± 39.8 vs 506.7 ± 29.2 mg kg
−1
day
−1
,
p
= 0.34, and 0.72 [0.53–1.15] vs 0.50 [0.32–0.68] mmol/l,
p
= 0.26). Weight loss decreased intraorgan fat and VLDL1-TG production rates regardless of sex, and these changes were accompanied by similar rates of diabetes remission (65.4% vs 71.0%) and CVD risk reduction (59.8% vs 41.5%) in women and men, respectively.
Conclusions/interpretation
In type 2 diabetes, women have liver and pancreas fat levels as high as those of men, associated with raised hepatic VLDL1-TG production rates. Dynamics of triacylglycerol turnover differ between sexes in type 2 diabetes and following weight loss. These changes may contribute to the disproportionately raised cardiovascular risk of women with diabetes.
Graphical abstract</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-021-05583-4</identifier><identifier>PMID: 34657182</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Body weight loss ; Cardiovascular diseases ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - metabolism ; Female ; Gender differences ; Human Physiology ; Humans ; Internal Medicine ; Lipid Metabolism ; Lipoproteins, VLDL ; Liver ; Liver - metabolism ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Pancreas ; Remission ; Remission (Medicine) ; Sex Characteristics ; Sex differences ; Short Communication ; Triglycerides ; Weight Loss ; Women</subject><ispartof>Diabetologia, 2022-01, Vol.65 (1), p.226-233</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-6d95ecdf403a6ecee132f2d0e5fefdd561bcf74a8e825941763337e76cb66a633</citedby><cites>FETCH-LOGICAL-c474t-6d95ecdf403a6ecee132f2d0e5fefdd561bcf74a8e825941763337e76cb66a633</cites><orcidid>0000-0003-2216-0083 ; 0000-0002-3135-8131 ; 0000-0001-6273-0170 ; 0000-0002-1604-2593 ; 0000-0002-7699-8853 ; 0000-0003-3689-1266 ; 0000-0002-7365-801X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00125-021-05583-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00125-021-05583-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34657182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jesuthasan, Aaron</creatorcontrib><creatorcontrib>Zhyzhneuskaya, Sviatlana</creatorcontrib><creatorcontrib>Peters, Carl</creatorcontrib><creatorcontrib>Barnes, Alison C.</creatorcontrib><creatorcontrib>Hollingsworth, Kieren G.</creatorcontrib><creatorcontrib>Sattar, Naveed</creatorcontrib><creatorcontrib>Lean, Michael E. J.</creatorcontrib><creatorcontrib>Taylor, Roy</creatorcontrib><creatorcontrib>Al-Mrabeh, Ahmad H.</creatorcontrib><title>Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><addtitle>Diabetologia</addtitle><description>Aims/hypothesis
Type 2 diabetes confers a greater relative increase in CVD risk in women compared with men. We examined sex differences in intraorgan fat and hepatic VLDL1-triacylglycerol (VLDL1-TG) export before and after major dietary weight loss.
Methods
A group with type 2 diabetes (
n
= 64, 30 male/34 female) and a group of healthy individuals (
n
= 25, 13 male/12 female) were studied. Intraorgan and visceral fat were quantified by magnetic resonance and VLDL1-TG export by intralipid infusion techniques.
Results
Triacylglycerol content of the liver and pancreas was elevated in people with diabetes with no sex differences (liver 16.4% [9.3–25.0%] in women vs 11.9% [7.0–23.1%] in men,
p
= 0.57, and pancreas 8.3 ± 0.5% vs 8.5 ± 0.4%,
p
= 0.83, respectively). In the absence of diabetes, fat levels in both organs were lower in women than men (1.0% [0.9–1.7%] vs 4.5% [1.9–8.0%],
p
= 0.005, and 4.7 ± 0.4% vs 7.6 ± 0.5%,
p
< 0.0001, respectively). Women with diabetes had higher hepatic VLDL1-TG production rate and plasma VLDL1-TG than healthy women (559.3 ± 32.9 vs 403.2 ± 45.7 mg kg
−1
day
−1
,
p
= 0.01, and 0.45 [0.26–0.77] vs 0.25 [0.13–0.33] mmol/l,
p
= 0.02), whereas there were no differences in men (548.8 ± 39.8 vs 506.7 ± 29.2 mg kg
−1
day
−1
,
p
= 0.34, and 0.72 [0.53–1.15] vs 0.50 [0.32–0.68] mmol/l,
p
= 0.26). Weight loss decreased intraorgan fat and VLDL1-TG production rates regardless of sex, and these changes were accompanied by similar rates of diabetes remission (65.4% vs 71.0%) and CVD risk reduction (59.8% vs 41.5%) in women and men, respectively.
Conclusions/interpretation
In type 2 diabetes, women have liver and pancreas fat levels as high as those of men, associated with raised hepatic VLDL1-TG production rates. Dynamics of triacylglycerol turnover differ between sexes in type 2 diabetes and following weight loss. These changes may contribute to the disproportionately raised cardiovascular risk of women with diabetes.
Graphical abstract</description><subject>Body weight loss</subject><subject>Cardiovascular diseases</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Female</subject><subject>Gender differences</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lipid Metabolism</subject><subject>Lipoproteins, VLDL</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Pancreas</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Short Communication</subject><subject>Triglycerides</subject><subject>Weight Loss</subject><subject>Women</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9Uk2LFDEQDaK44-of8CABL15a89XpHg_CsvgFCx5U8BbSSWUmS7rTJj2j-4_8mdbsrOvHQUgIxXv16lWlCHnM2XPOWPeiMsZF2zDBG9a2vWzUHbLiSoqGKdHfJasD3vBefzkhD2q9ZIzJVun75EQq3Xa8Fyvy4yN8pz6GAAUmB5XGCc9SbC4bO9FgF5pgD6lSO3m6hdku0dEU5-jpCIsdcop1fEnjOKfoEMxTpSEX6mzxMe9tdbtkC2batGyvRQqMsVYk0hzocjUDFejADrBgeRsWKBiidLmi3yButugg1_qQ3As2VXh0856Sz29efzp_11x8ePv-_OyicapTS6P9ugXng2LSanAAXIogPIM2QPC-1XxwoVO2h160a8U7LaXsoNNu0NpicEpeHXXn3TCCd3AYRjJziSM6MtlG8zcyxa3Z5L3ptWZdu0aBZzcCJX_dQV0MtusgJTtB3lUj8Kek6JTWSH36D_Uy78qE7RmhWX-4skeWOLJcwTkUCLdmODOHRTDHRTC4COZ6EYzCpCd_tnGb8uvnkSCPhIrQtIHyu_Z_ZH8CEELDbg</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Jesuthasan, Aaron</creator><creator>Zhyzhneuskaya, Sviatlana</creator><creator>Peters, Carl</creator><creator>Barnes, Alison C.</creator><creator>Hollingsworth, Kieren G.</creator><creator>Sattar, Naveed</creator><creator>Lean, Michael E. J.</creator><creator>Taylor, Roy</creator><creator>Al-Mrabeh, Ahmad H.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2216-0083</orcidid><orcidid>https://orcid.org/0000-0002-3135-8131</orcidid><orcidid>https://orcid.org/0000-0001-6273-0170</orcidid><orcidid>https://orcid.org/0000-0002-1604-2593</orcidid><orcidid>https://orcid.org/0000-0002-7699-8853</orcidid><orcidid>https://orcid.org/0000-0003-3689-1266</orcidid><orcidid>https://orcid.org/0000-0002-7365-801X</orcidid></search><sort><creationdate>20220101</creationdate><title>Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss</title><author>Jesuthasan, Aaron ; Zhyzhneuskaya, Sviatlana ; Peters, Carl ; Barnes, Alison C. ; Hollingsworth, Kieren G. ; Sattar, Naveed ; Lean, Michael E. J. ; Taylor, Roy ; Al-Mrabeh, Ahmad H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-6d95ecdf403a6ecee132f2d0e5fefdd561bcf74a8e825941763337e76cb66a633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Body weight loss</topic><topic>Cardiovascular diseases</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Female</topic><topic>Gender differences</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lipid Metabolism</topic><topic>Lipoproteins, VLDL</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Pancreas</topic><topic>Remission</topic><topic>Remission (Medicine)</topic><topic>Sex Characteristics</topic><topic>Sex differences</topic><topic>Short Communication</topic><topic>Triglycerides</topic><topic>Weight Loss</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jesuthasan, Aaron</creatorcontrib><creatorcontrib>Zhyzhneuskaya, Sviatlana</creatorcontrib><creatorcontrib>Peters, Carl</creatorcontrib><creatorcontrib>Barnes, Alison C.</creatorcontrib><creatorcontrib>Hollingsworth, Kieren G.</creatorcontrib><creatorcontrib>Sattar, Naveed</creatorcontrib><creatorcontrib>Lean, Michael E. J.</creatorcontrib><creatorcontrib>Taylor, Roy</creatorcontrib><creatorcontrib>Al-Mrabeh, Ahmad H.</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jesuthasan, Aaron</au><au>Zhyzhneuskaya, Sviatlana</au><au>Peters, Carl</au><au>Barnes, Alison C.</au><au>Hollingsworth, Kieren G.</au><au>Sattar, Naveed</au><au>Lean, Michael E. J.</au><au>Taylor, Roy</au><au>Al-Mrabeh, Ahmad H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss</atitle><jtitle>Diabetologia</jtitle><stitle>Diabetologia</stitle><addtitle>Diabetologia</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>65</volume><issue>1</issue><spage>226</spage><epage>233</epage><pages>226-233</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Aims/hypothesis
Type 2 diabetes confers a greater relative increase in CVD risk in women compared with men. We examined sex differences in intraorgan fat and hepatic VLDL1-triacylglycerol (VLDL1-TG) export before and after major dietary weight loss.
Methods
A group with type 2 diabetes (
n
= 64, 30 male/34 female) and a group of healthy individuals (
n
= 25, 13 male/12 female) were studied. Intraorgan and visceral fat were quantified by magnetic resonance and VLDL1-TG export by intralipid infusion techniques.
Results
Triacylglycerol content of the liver and pancreas was elevated in people with diabetes with no sex differences (liver 16.4% [9.3–25.0%] in women vs 11.9% [7.0–23.1%] in men,
p
= 0.57, and pancreas 8.3 ± 0.5% vs 8.5 ± 0.4%,
p
= 0.83, respectively). In the absence of diabetes, fat levels in both organs were lower in women than men (1.0% [0.9–1.7%] vs 4.5% [1.9–8.0%],
p
= 0.005, and 4.7 ± 0.4% vs 7.6 ± 0.5%,
p
< 0.0001, respectively). Women with diabetes had higher hepatic VLDL1-TG production rate and plasma VLDL1-TG than healthy women (559.3 ± 32.9 vs 403.2 ± 45.7 mg kg
−1
day
−1
,
p
= 0.01, and 0.45 [0.26–0.77] vs 0.25 [0.13–0.33] mmol/l,
p
= 0.02), whereas there were no differences in men (548.8 ± 39.8 vs 506.7 ± 29.2 mg kg
−1
day
−1
,
p
= 0.34, and 0.72 [0.53–1.15] vs 0.50 [0.32–0.68] mmol/l,
p
= 0.26). Weight loss decreased intraorgan fat and VLDL1-TG production rates regardless of sex, and these changes were accompanied by similar rates of diabetes remission (65.4% vs 71.0%) and CVD risk reduction (59.8% vs 41.5%) in women and men, respectively.
Conclusions/interpretation
In type 2 diabetes, women have liver and pancreas fat levels as high as those of men, associated with raised hepatic VLDL1-TG production rates. Dynamics of triacylglycerol turnover differ between sexes in type 2 diabetes and following weight loss. These changes may contribute to the disproportionately raised cardiovascular risk of women with diabetes.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34657182</pmid><doi>10.1007/s00125-021-05583-4</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2216-0083</orcidid><orcidid>https://orcid.org/0000-0002-3135-8131</orcidid><orcidid>https://orcid.org/0000-0001-6273-0170</orcidid><orcidid>https://orcid.org/0000-0002-1604-2593</orcidid><orcidid>https://orcid.org/0000-0002-7699-8853</orcidid><orcidid>https://orcid.org/0000-0003-3689-1266</orcidid><orcidid>https://orcid.org/0000-0002-7365-801X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-186X |
| ispartof | Diabetologia, 2022-01, Vol.65 (1), p.226-233 |
| issn | 0012-186X 1432-0428 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8660759 |
| source | MEDLINE; SpringerLink |
| subjects | Body weight loss Cardiovascular diseases Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Female Gender differences Human Physiology Humans Internal Medicine Lipid Metabolism Lipoproteins, VLDL Liver Liver - metabolism Male Medicine Medicine & Public Health Metabolic Diseases Pancreas Remission Remission (Medicine) Sex Characteristics Sex differences Short Communication Triglycerides Weight Loss Women |
| title | Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T18%3A42%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex%20differences%20in%20intraorgan%20fat%20levels%20and%20hepatic%20lipid%20metabolism:%20implications%20for%20cardiovascular%20health%20and%20remission%20of%20type%202%20diabetes%20after%20dietary%20weight%20loss&rft.jtitle=Diabetologia&rft.au=Jesuthasan,%20Aaron&rft.date=2022-01-01&rft.volume=65&rft.issue=1&rft.spage=226&rft.epage=233&rft.pages=226-233&rft.issn=0012-186X&rft.eissn=1432-0428&rft_id=info:doi/10.1007/s00125-021-05583-4&rft_dat=%3Cproquest_pubme%3E2608260838%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2608260838&rft_id=info:pmid/34657182&rfr_iscdi=true |