Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells
Long noncoding RNA nuclear paraspeckle assembly transcript 1 (lncRNA NEAT1) is abnormally expressed in numerous tumors and functions as an oncogene, but the role of NEAT1 in laryngocarcinoma is largely unknown. Our study validated that NEAT1 expression was markedly upregulated in laryngocarcinoma ti...
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| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2021-11, Vol.13 (22), p.24850-24865 |
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| creator | Zhang, Jiajia Wang, Ping Cui, Yanli |
| description | Long noncoding RNA nuclear paraspeckle assembly transcript 1 (lncRNA NEAT1) is abnormally expressed in numerous tumors and functions as an oncogene, but the role of NEAT1 in laryngocarcinoma is largely unknown. Our study validated that NEAT1 expression was markedly upregulated in laryngocarcinoma tissues and cells. Downregulation of NEAT1 dramatically suppressed cell proliferation and invasion through inhibiting miR-524-5p expression. Additionally, NEAT1 overexpression promoted cell growth and metastasis, while overexpression of miR-524-5p could reverse the effect. NEAT1 increased the expression of histone deacetylase 1 gene (HDAC1) via sponging miR-524-5p. Mechanistically, overexpression of HDAC1 recovered the cancer-inhibiting effects of miR-524-5p mimic or NEAT1 silence by deacetylation of tensin homolog deleted on chromosome ten (PTEN) and inhibiting AKT signal pathway. Moreover,
experiments indicated that silence of NEAT1 signally suppressed tumor growth. Taken together, knockdown of NEAT1 suppressed laryngocarcinoma cell growth and metastasis by miR-524-5p/HDAC1/PTEN/AKT signal pathway, which provided a potential therapeutic target for laryngocarcinoma. |
| doi_str_mv | 10.18632/aging.203719 |
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experiments indicated that silence of NEAT1 signally suppressed tumor growth. Taken together, knockdown of NEAT1 suppressed laryngocarcinoma cell growth and metastasis by miR-524-5p/HDAC1/PTEN/AKT signal pathway, which provided a potential therapeutic target for laryngocarcinoma.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.203719</identifier><identifier>PMID: 34837887</identifier><language>eng</language><publisher>United States: Impact Journals</publisher><subject>Acetylation ; Adult ; Cell Proliferation - genetics ; Female ; Histone Deacetylase 1 - genetics ; Histone Deacetylase 1 - metabolism ; Humans ; Laryngeal Neoplasms - genetics ; Laryngeal Neoplasms - metabolism ; Laryngeal Neoplasms - pathology ; Male ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Middle Aged ; Neoplasm Invasiveness - genetics ; PTEN Phosphohydrolase - chemistry ; PTEN Phosphohydrolase - genetics ; PTEN Phosphohydrolase - metabolism ; Research Paper ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism</subject><ispartof>Aging (Albany, NY.), 2021-11, Vol.13 (22), p.24850-24865</ispartof><rights>Copyright: © 2021 Zhang et al.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-92cd437a60266b89bdcf34d659527b9f36042ecf981bd12beed6f320206214003</citedby><cites>FETCH-LOGICAL-c387t-92cd437a60266b89bdcf34d659527b9f36042ecf981bd12beed6f320206214003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660614/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660614/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34837887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jiajia</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><creatorcontrib>Cui, Yanli</creatorcontrib><title>Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>Long noncoding RNA nuclear paraspeckle assembly transcript 1 (lncRNA NEAT1) is abnormally expressed in numerous tumors and functions as an oncogene, but the role of NEAT1 in laryngocarcinoma is largely unknown. Our study validated that NEAT1 expression was markedly upregulated in laryngocarcinoma tissues and cells. Downregulation of NEAT1 dramatically suppressed cell proliferation and invasion through inhibiting miR-524-5p expression. Additionally, NEAT1 overexpression promoted cell growth and metastasis, while overexpression of miR-524-5p could reverse the effect. NEAT1 increased the expression of histone deacetylase 1 gene (HDAC1) via sponging miR-524-5p. Mechanistically, overexpression of HDAC1 recovered the cancer-inhibiting effects of miR-524-5p mimic or NEAT1 silence by deacetylation of tensin homolog deleted on chromosome ten (PTEN) and inhibiting AKT signal pathway. Moreover,
experiments indicated that silence of NEAT1 signally suppressed tumor growth. Taken together, knockdown of NEAT1 suppressed laryngocarcinoma cell growth and metastasis by miR-524-5p/HDAC1/PTEN/AKT signal pathway, which provided a potential therapeutic target for laryngocarcinoma.</description><subject>Acetylation</subject><subject>Adult</subject><subject>Cell Proliferation - genetics</subject><subject>Female</subject><subject>Histone Deacetylase 1 - genetics</subject><subject>Histone Deacetylase 1 - metabolism</subject><subject>Humans</subject><subject>Laryngeal Neoplasms - genetics</subject><subject>Laryngeal Neoplasms - metabolism</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Male</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>PTEN Phosphohydrolase - chemistry</subject><subject>PTEN Phosphohydrolase - genetics</subject><subject>PTEN Phosphohydrolase - metabolism</subject><subject>Research Paper</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtP4zAUhS00iEdhyXbk5WwCfsVxNkhVpzykqiBU1pbjOKlHiV3sFA3_hp-KaQsqK1_5Hn_3XB8ALjC6xIJTcqVa69pLgmiBywNwgkuWZywX5a-9-hicxvgPIZ7njB-BY8oELYQoTsD7zLsWOu-0rxMHPs3HcD4dLzC0bmkrO0Q4LA1U2gxvnRqsd9A38HExnaf74NftctPv7VOWE5blK3h193c8wVD9t-mph6vgez-YjSrVnW1M2HKUq9OQVxV30E6FN9ca1UGtnDYBatN18QwcNqqL5nx3jsDzzXQxuctmD7f3k_Es01QUQ1YSXTNaKI4I55Uoq1o3lNU8L3NSVGVDOWLE6KYUuKoxqYypeUMJIogTzBCiI3C95a7WVW9qbdwQVCdXwfbJl_TKyp8dZ5ey9a9ScI44ZgnwZwcI_mVt4iB7Gz9XUM74dZQkOUA4_TtO0mwr1cHHGEzzPQYjuUlVblKV21ST_ve-t2_1V4z0A1mkn1g</recordid><startdate>20211127</startdate><enddate>20211127</enddate><creator>Zhang, Jiajia</creator><creator>Wang, Ping</creator><creator>Cui, Yanli</creator><general>Impact Journals</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211127</creationdate><title>Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells</title><author>Zhang, Jiajia ; Wang, Ping ; Cui, Yanli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-92cd437a60266b89bdcf34d659527b9f36042ecf981bd12beed6f320206214003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetylation</topic><topic>Adult</topic><topic>Cell Proliferation - genetics</topic><topic>Female</topic><topic>Histone Deacetylase 1 - genetics</topic><topic>Histone Deacetylase 1 - metabolism</topic><topic>Humans</topic><topic>Laryngeal Neoplasms - genetics</topic><topic>Laryngeal Neoplasms - metabolism</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Male</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>PTEN Phosphohydrolase - chemistry</topic><topic>PTEN Phosphohydrolase - genetics</topic><topic>PTEN Phosphohydrolase - metabolism</topic><topic>Research Paper</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jiajia</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><creatorcontrib>Cui, Yanli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jiajia</au><au>Wang, Ping</au><au>Cui, Yanli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2021-11-27</date><risdate>2021</risdate><volume>13</volume><issue>22</issue><spage>24850</spage><epage>24865</epage><pages>24850-24865</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><abstract>Long noncoding RNA nuclear paraspeckle assembly transcript 1 (lncRNA NEAT1) is abnormally expressed in numerous tumors and functions as an oncogene, but the role of NEAT1 in laryngocarcinoma is largely unknown. Our study validated that NEAT1 expression was markedly upregulated in laryngocarcinoma tissues and cells. Downregulation of NEAT1 dramatically suppressed cell proliferation and invasion through inhibiting miR-524-5p expression. Additionally, NEAT1 overexpression promoted cell growth and metastasis, while overexpression of miR-524-5p could reverse the effect. NEAT1 increased the expression of histone deacetylase 1 gene (HDAC1) via sponging miR-524-5p. Mechanistically, overexpression of HDAC1 recovered the cancer-inhibiting effects of miR-524-5p mimic or NEAT1 silence by deacetylation of tensin homolog deleted on chromosome ten (PTEN) and inhibiting AKT signal pathway. Moreover,
experiments indicated that silence of NEAT1 signally suppressed tumor growth. Taken together, knockdown of NEAT1 suppressed laryngocarcinoma cell growth and metastasis by miR-524-5p/HDAC1/PTEN/AKT signal pathway, which provided a potential therapeutic target for laryngocarcinoma.</abstract><cop>United States</cop><pub>Impact Journals</pub><pmid>34837887</pmid><doi>10.18632/aging.203719</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Acetylation Adult Cell Proliferation - genetics Female Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Humans Laryngeal Neoplasms - genetics Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Male MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Neoplasm Invasiveness - genetics PTEN Phosphohydrolase - chemistry PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Research Paper RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism |
| title | Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells |
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