BMAL1 may be involved in angiogenesis and peritumoral cerebral edema of human glioma by regulating VEGF and ANG2
The rhythm gene (Brain and Muscle ARNT-Like 1) may play an important role in glioma tolerance for anti-angiogenesis therapy. In humans with glioma of different pathological grades, expression was significantly different, and the expression of (Angiopoietin 2) and (Vascular endothelial growth factor)...
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| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2021-11, Vol.13 (22), p.24675-24685 |
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| creator | Wang, Fan Li, CaiYan Han, Fei Chen, LvAn Zhu, Ling |
| description | The rhythm gene
(Brain and Muscle ARNT-Like 1) may play an important role in glioma tolerance for anti-angiogenesis therapy. In humans with glioma of different pathological grades,
expression was significantly different, and the expression of
(Angiopoietin 2) and
(Vascular endothelial growth factor) was positively correlated with the expression of
. Additionally,
expression is positively correlated with the microvascular density and peritumoral edema of glioma. According to
experiments, silencing the expression of
in primary glioma cells results in a decrease in the expression of
. In contrast, overexpression of
promotes the expression of
and
via
pathway. Therefore,
likely participates in the angiogenesis of glioma by modulating
and
expression, alters the therapeutic effect of anti-angiogenic treatments, and promotes peritumoral brain edema of glioma. |
| doi_str_mv | 10.18632/aging.203708 |
| format | Article |
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(Brain and Muscle ARNT-Like 1) may play an important role in glioma tolerance for anti-angiogenesis therapy. In humans with glioma of different pathological grades,
expression was significantly different, and the expression of
(Angiopoietin 2) and
(Vascular endothelial growth factor) was positively correlated with the expression of
. Additionally,
expression is positively correlated with the microvascular density and peritumoral edema of glioma. According to
experiments, silencing the expression of
in primary glioma cells results in a decrease in the expression of
. In contrast, overexpression of
promotes the expression of
and
via
pathway. Therefore,
likely participates in the angiogenesis of glioma by modulating
and
expression, alters the therapeutic effect of anti-angiogenic treatments, and promotes peritumoral brain edema of glioma.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.203708</identifier><identifier>PMID: 34815366</identifier><language>eng</language><publisher>United States: Impact Journals</publisher><subject>Adolescent ; Adult ; Aged ; Angiopoietin-2 - genetics ; Angiopoietin-2 - metabolism ; ARNTL Transcription Factors - genetics ; ARNTL Transcription Factors - metabolism ; Brain Edema - metabolism ; Brain Neoplasms - genetics ; Brain Neoplasms - metabolism ; Female ; Glioma - genetics ; Glioma - metabolism ; Glioma - pathology ; Humans ; Male ; Middle Aged ; Neovascularization, Pathologic - genetics ; Research Paper ; Vascular Endothelial Growth Factor A - genetics ; Vascular Endothelial Growth Factor A - metabolism ; Young Adult</subject><ispartof>Aging (Albany, NY.), 2021-11, Vol.13 (22), p.24675-24685</ispartof><rights>Copyright: © 2021 Wang et al.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-585a428ba03981049a2415a6b5489ffc7d9ccb9a0d32ae99ab30b91f568188ac3</citedby><cites>FETCH-LOGICAL-c387t-585a428ba03981049a2415a6b5489ffc7d9ccb9a0d32ae99ab30b91f568188ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660602/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660602/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34815366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Fan</creatorcontrib><creatorcontrib>Li, CaiYan</creatorcontrib><creatorcontrib>Han, Fei</creatorcontrib><creatorcontrib>Chen, LvAn</creatorcontrib><creatorcontrib>Zhu, Ling</creatorcontrib><title>BMAL1 may be involved in angiogenesis and peritumoral cerebral edema of human glioma by regulating VEGF and ANG2</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>The rhythm gene
(Brain and Muscle ARNT-Like 1) may play an important role in glioma tolerance for anti-angiogenesis therapy. In humans with glioma of different pathological grades,
expression was significantly different, and the expression of
(Angiopoietin 2) and
(Vascular endothelial growth factor) was positively correlated with the expression of
. Additionally,
expression is positively correlated with the microvascular density and peritumoral edema of glioma. According to
experiments, silencing the expression of
in primary glioma cells results in a decrease in the expression of
. In contrast, overexpression of
promotes the expression of
and
via
pathway. Therefore,
likely participates in the angiogenesis of glioma by modulating
and
expression, alters the therapeutic effect of anti-angiogenic treatments, and promotes peritumoral brain edema of glioma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Angiopoietin-2 - genetics</subject><subject>Angiopoietin-2 - metabolism</subject><subject>ARNTL Transcription Factors - genetics</subject><subject>ARNTL Transcription Factors - metabolism</subject><subject>Brain Edema - metabolism</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - metabolism</subject><subject>Female</subject><subject>Glioma - genetics</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neovascularization, Pathologic - genetics</subject><subject>Research Paper</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>Young Adult</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1v1DAQxS0EoqVw5Ip85JLWH7HXviAtVbsgLXABrtbYmaRGSbzYyUr73zfslqo9zRvN02-e9Ah5z9klN1qKK-ji2F0KJlfMvCDn3NaqqpWxL5_oM_KmlD-MaaVq_ZqcydpwJbU-J7vP39ZbTgc4UI80jvvU77FZBIWxi6nDEUssy9LQHeY4zUPK0NOAGf0_gQ0OQFNL7-YBRtr1MS27P9CM3dzDtGSjv282t0fC-vtGvCWvWugLvnuYF-TX7c3P6y_V9sfm6_V6WwVpVlOljIJaGA9MWsNZbUHUXIH2qja2bcOqsSF4C6yRAtBa8JJ5y1ulDTcGgrwgn07c3ewHbAKO05LX7XIcIB9cguieX8Z457q0d0ZrpplYAB8fADn9nbFMboglYN_DiGkuTmjGrZUrYRdrdbKGnErJ2D6-4cwdW3LHltyppcX_4Wm2R_f_WuQ9QDePDA</recordid><startdate>20211123</startdate><enddate>20211123</enddate><creator>Wang, Fan</creator><creator>Li, CaiYan</creator><creator>Han, Fei</creator><creator>Chen, LvAn</creator><creator>Zhu, Ling</creator><general>Impact Journals</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211123</creationdate><title>BMAL1 may be involved in angiogenesis and peritumoral cerebral edema of human glioma by regulating VEGF and ANG2</title><author>Wang, Fan ; Li, CaiYan ; Han, Fei ; Chen, LvAn ; Zhu, Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-585a428ba03981049a2415a6b5489ffc7d9ccb9a0d32ae99ab30b91f568188ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Angiopoietin-2 - genetics</topic><topic>Angiopoietin-2 - metabolism</topic><topic>ARNTL Transcription Factors - genetics</topic><topic>ARNTL Transcription Factors - metabolism</topic><topic>Brain Edema - metabolism</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - metabolism</topic><topic>Female</topic><topic>Glioma - genetics</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neovascularization, Pathologic - genetics</topic><topic>Research Paper</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Fan</creatorcontrib><creatorcontrib>Li, CaiYan</creatorcontrib><creatorcontrib>Han, Fei</creatorcontrib><creatorcontrib>Chen, LvAn</creatorcontrib><creatorcontrib>Zhu, Ling</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Fan</au><au>Li, CaiYan</au><au>Han, Fei</au><au>Chen, LvAn</au><au>Zhu, Ling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BMAL1 may be involved in angiogenesis and peritumoral cerebral edema of human glioma by regulating VEGF and ANG2</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2021-11-23</date><risdate>2021</risdate><volume>13</volume><issue>22</issue><spage>24675</spage><epage>24685</epage><pages>24675-24685</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><abstract>The rhythm gene
(Brain and Muscle ARNT-Like 1) may play an important role in glioma tolerance for anti-angiogenesis therapy. In humans with glioma of different pathological grades,
expression was significantly different, and the expression of
(Angiopoietin 2) and
(Vascular endothelial growth factor) was positively correlated with the expression of
. Additionally,
expression is positively correlated with the microvascular density and peritumoral edema of glioma. According to
experiments, silencing the expression of
in primary glioma cells results in a decrease in the expression of
. In contrast, overexpression of
promotes the expression of
and
via
pathway. Therefore,
likely participates in the angiogenesis of glioma by modulating
and
expression, alters the therapeutic effect of anti-angiogenic treatments, and promotes peritumoral brain edema of glioma.</abstract><cop>United States</cop><pub>Impact Journals</pub><pmid>34815366</pmid><doi>10.18632/aging.203708</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Adolescent Adult Aged Angiopoietin-2 - genetics Angiopoietin-2 - metabolism ARNTL Transcription Factors - genetics ARNTL Transcription Factors - metabolism Brain Edema - metabolism Brain Neoplasms - genetics Brain Neoplasms - metabolism Female Glioma - genetics Glioma - metabolism Glioma - pathology Humans Male Middle Aged Neovascularization, Pathologic - genetics Research Paper Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Young Adult |
| title | BMAL1 may be involved in angiogenesis and peritumoral cerebral edema of human glioma by regulating VEGF and ANG2 |
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