Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function
(1) Background: Highly sensitive cardiac troponin T (hs-cTnT) plays an essential role in the diagnosis of myocardial injury. The upper reference limit of the respective assay is generally applied, irrespective of age, renal function, or sex. We aimed to identify age-adjusted and sex-adjusted upper r...
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| Veröffentlicht in: | Journal of clinical medicine 2021-11, Vol.10 (23), p.5508 |
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| description | (1) Background: Highly sensitive cardiac troponin T (hs-cTnT) plays an essential role in the diagnosis of myocardial injury. The upper reference limit of the respective assay is generally applied, irrespective of age, renal function, or sex. We aimed to identify age-adjusted and sex-adjusted upper reference limits in relation to renal function in a large population-based cohort without cardiac diseases. (2) Methods: We included 5428 subjects of the population-based LIFE-Adult cohort, free of diagnosed cardiac diseases. Sex-adjusted and age-adjusted 99th percentiles for hs-cTnT in subjects with preserved renal function were obtained. (3) Results: The hs-cTnT values were higher in men of all age groups. In both sexes, an increasing age positively correlated with higher hs-cTnT values. Hs-cTnT weakly correlated with serum creatinine. The three-dimensional analysis of age, creatinine, and hs-cTnT showed no relevant additional effect of creatinine on hs-cTnT. In men aged above 60 and women above 70, the calculated 99th percentiles clearly exceeded the commonly applied thresholds. (4) Conclusion: Age and sex have a major impact on the serum concentration of hs-cTnT, while renal function does not. We propose to consider age-adjusted and sex-adjusted reference values. |
| doi_str_mv | 10.3390/jcm10235508 |
| format | Article |
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The upper reference limit of the respective assay is generally applied, irrespective of age, renal function, or sex. We aimed to identify age-adjusted and sex-adjusted upper reference limits in relation to renal function in a large population-based cohort without cardiac diseases. (2) Methods: We included 5428 subjects of the population-based LIFE-Adult cohort, free of diagnosed cardiac diseases. Sex-adjusted and age-adjusted 99th percentiles for hs-cTnT in subjects with preserved renal function were obtained. (3) Results: The hs-cTnT values were higher in men of all age groups. In both sexes, an increasing age positively correlated with higher hs-cTnT values. Hs-cTnT weakly correlated with serum creatinine. The three-dimensional analysis of age, creatinine, and hs-cTnT showed no relevant additional effect of creatinine on hs-cTnT. In men aged above 60 and women above 70, the calculated 99th percentiles clearly exceeded the commonly applied thresholds. (4) Conclusion: Age and sex have a major impact on the serum concentration of hs-cTnT, while renal function does not. We propose to consider age-adjusted and sex-adjusted reference values.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm10235508</identifier><identifier>PMID: 34884210</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age groups ; Angina pectoris ; Clinical medicine ; Creatinine ; Dimensional analysis ; Disease ; Hemoglobin ; Immunoassay ; Laboratories ; Population ; Questionnaires ; Sexes ; Womens health</subject><ispartof>Journal of clinical medicine, 2021-11, Vol.10 (23), p.5508</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-9e7817824c7fad7ca860bece7404d5025483eccbbb2ec0a6f0377e82d97be9283</citedby><cites>FETCH-LOGICAL-c409t-9e7817824c7fad7ca860bece7404d5025483eccbbb2ec0a6f0377e82d97be9283</cites><orcidid>0000-0002-1126-5763 ; 0000-0001-6221-2496 ; 0000-0003-0714-6160 ; 0000-0001-8095-2463 ; 0000-0003-0523-3113 ; 0000-0002-9479-3659</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658212/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658212/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34884210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gärtner, Christiane</creatorcontrib><creatorcontrib>Langhammer, Romy</creatorcontrib><creatorcontrib>Schmidt, Maria</creatorcontrib><creatorcontrib>Federbusch, Martin</creatorcontrib><creatorcontrib>Wirkner, Kerstin</creatorcontrib><creatorcontrib>Löffler, Markus</creatorcontrib><creatorcontrib>Isermann, Berend</creatorcontrib><creatorcontrib>Laufs, Ulrich</creatorcontrib><creatorcontrib>Wachter, Rolf</creatorcontrib><creatorcontrib>Kaiser, Thorsten</creatorcontrib><title>Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>(1) Background: Highly sensitive cardiac troponin T (hs-cTnT) plays an essential role in the diagnosis of myocardial injury. The upper reference limit of the respective assay is generally applied, irrespective of age, renal function, or sex. We aimed to identify age-adjusted and sex-adjusted upper reference limits in relation to renal function in a large population-based cohort without cardiac diseases. (2) Methods: We included 5428 subjects of the population-based LIFE-Adult cohort, free of diagnosed cardiac diseases. Sex-adjusted and age-adjusted 99th percentiles for hs-cTnT in subjects with preserved renal function were obtained. (3) Results: The hs-cTnT values were higher in men of all age groups. In both sexes, an increasing age positively correlated with higher hs-cTnT values. Hs-cTnT weakly correlated with serum creatinine. The three-dimensional analysis of age, creatinine, and hs-cTnT showed no relevant additional effect of creatinine on hs-cTnT. In men aged above 60 and women above 70, the calculated 99th percentiles clearly exceeded the commonly applied thresholds. (4) Conclusion: Age and sex have a major impact on the serum concentration of hs-cTnT, while renal function does not. We propose to consider age-adjusted and sex-adjusted reference values.</description><subject>Age groups</subject><subject>Angina pectoris</subject><subject>Clinical medicine</subject><subject>Creatinine</subject><subject>Dimensional analysis</subject><subject>Disease</subject><subject>Hemoglobin</subject><subject>Immunoassay</subject><subject>Laboratories</subject><subject>Population</subject><subject>Questionnaires</subject><subject>Sexes</subject><subject>Womens health</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkd1LwzAUxYMoKuqT7xLwRdBpmrRN-iLI8AsGwpzPIU1vZ0ab1KQd-t-bOZVpHpIL55fDuRyEjhNyyVhBrha6TQhlWUbEFtqnhPMRYYJtb8x76CiEBYlHiJQmfBftsfRrJPuon8LSBNNDhV-6DjyeQg0erAY8Ma3pA66dxw9m_tp84GewETVLwGPlK6M0nnnXOWssnuF4TaFRvXEW9w7fzOEifni_wMpWUbGqwXeD1Sv9EO3Uqglw9P0eoJe729n4YTR5un8c30xGOiVFPyqAi4QLmmpeq4prJXJSggaekrTKCM1SwUDrsiwpaKLymjDOQdCq4CUUVLADdL327YayhUqD7b1qZOdNq_yHdMrIv4o1r3LullLkmaAJjQZn3wbevQ0QetmaoKFplAU3BElzIjKW5lke0dN_6MINPm69ppKkENkq0fma0t6F4KH-DZMQuSpUbhQa6ZPN_L_sT33sE5U2m9w</recordid><startdate>20211125</startdate><enddate>20211125</enddate><creator>Gärtner, Christiane</creator><creator>Langhammer, Romy</creator><creator>Schmidt, Maria</creator><creator>Federbusch, Martin</creator><creator>Wirkner, Kerstin</creator><creator>Löffler, Markus</creator><creator>Isermann, Berend</creator><creator>Laufs, Ulrich</creator><creator>Wachter, Rolf</creator><creator>Kaiser, Thorsten</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1126-5763</orcidid><orcidid>https://orcid.org/0000-0001-6221-2496</orcidid><orcidid>https://orcid.org/0000-0003-0714-6160</orcidid><orcidid>https://orcid.org/0000-0001-8095-2463</orcidid><orcidid>https://orcid.org/0000-0003-0523-3113</orcidid><orcidid>https://orcid.org/0000-0002-9479-3659</orcidid></search><sort><creationdate>20211125</creationdate><title>Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function</title><author>Gärtner, Christiane ; Langhammer, Romy ; Schmidt, Maria ; Federbusch, Martin ; Wirkner, Kerstin ; Löffler, Markus ; Isermann, Berend ; Laufs, Ulrich ; Wachter, Rolf ; Kaiser, Thorsten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-9e7817824c7fad7ca860bece7404d5025483eccbbb2ec0a6f0377e82d97be9283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age groups</topic><topic>Angina pectoris</topic><topic>Clinical medicine</topic><topic>Creatinine</topic><topic>Dimensional analysis</topic><topic>Disease</topic><topic>Hemoglobin</topic><topic>Immunoassay</topic><topic>Laboratories</topic><topic>Population</topic><topic>Questionnaires</topic><topic>Sexes</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gärtner, Christiane</creatorcontrib><creatorcontrib>Langhammer, Romy</creatorcontrib><creatorcontrib>Schmidt, Maria</creatorcontrib><creatorcontrib>Federbusch, Martin</creatorcontrib><creatorcontrib>Wirkner, Kerstin</creatorcontrib><creatorcontrib>Löffler, Markus</creatorcontrib><creatorcontrib>Isermann, Berend</creatorcontrib><creatorcontrib>Laufs, Ulrich</creatorcontrib><creatorcontrib>Wachter, Rolf</creatorcontrib><creatorcontrib>Kaiser, Thorsten</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gärtner, Christiane</au><au>Langhammer, Romy</au><au>Schmidt, Maria</au><au>Federbusch, Martin</au><au>Wirkner, Kerstin</au><au>Löffler, Markus</au><au>Isermann, Berend</au><au>Laufs, Ulrich</au><au>Wachter, Rolf</au><au>Kaiser, Thorsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2021-11-25</date><risdate>2021</risdate><volume>10</volume><issue>23</issue><spage>5508</spage><pages>5508-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>(1) Background: Highly sensitive cardiac troponin T (hs-cTnT) plays an essential role in the diagnosis of myocardial injury. The upper reference limit of the respective assay is generally applied, irrespective of age, renal function, or sex. We aimed to identify age-adjusted and sex-adjusted upper reference limits in relation to renal function in a large population-based cohort without cardiac diseases. (2) Methods: We included 5428 subjects of the population-based LIFE-Adult cohort, free of diagnosed cardiac diseases. Sex-adjusted and age-adjusted 99th percentiles for hs-cTnT in subjects with preserved renal function were obtained. (3) Results: The hs-cTnT values were higher in men of all age groups. In both sexes, an increasing age positively correlated with higher hs-cTnT values. Hs-cTnT weakly correlated with serum creatinine. The three-dimensional analysis of age, creatinine, and hs-cTnT showed no relevant additional effect of creatinine on hs-cTnT. In men aged above 60 and women above 70, the calculated 99th percentiles clearly exceeded the commonly applied thresholds. (4) Conclusion: Age and sex have a major impact on the serum concentration of hs-cTnT, while renal function does not. We propose to consider age-adjusted and sex-adjusted reference values.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34884210</pmid><doi>10.3390/jcm10235508</doi><orcidid>https://orcid.org/0000-0002-1126-5763</orcidid><orcidid>https://orcid.org/0000-0001-6221-2496</orcidid><orcidid>https://orcid.org/0000-0003-0714-6160</orcidid><orcidid>https://orcid.org/0000-0001-8095-2463</orcidid><orcidid>https://orcid.org/0000-0003-0523-3113</orcidid><orcidid>https://orcid.org/0000-0002-9479-3659</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age groups Angina pectoris Clinical medicine Creatinine Dimensional analysis Disease Hemoglobin Immunoassay Laboratories Population Questionnaires Sexes Womens health |
| title | Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function |
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