Bare Metal Stents on Resveratrol-Coated Balloons in Porcine Coronary and Peripheral Arteries
Balloon angioplasty and stent implantation are standard techniques to reopen stenotic vessels. Often, balloons or stents coated with cytostatic drugs are used to prevent re-occlusion of the arteries. Resveratrol, which is known for its numerous beneficial effects on cardiovascular health, is used as...
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| Veröffentlicht in: | International journal of molecular sciences 2021-12, Vol.22 (23), p.13099 |
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| creator | Kamann, Stefanie Haase, Tobias Stolzenburg, Nicola Löchel, Melanie Peters-Berg, Daniel Schütt, Denise Schnorr, Jörg |
| description | Balloon angioplasty and stent implantation are standard techniques to reopen stenotic vessels. Often, balloons or stents coated with cytostatic drugs are used to prevent re-occlusion of the arteries. Resveratrol, which is known for its numerous beneficial effects on cardiovascular health, is used as an antioxidant additive on paclitaxel-coated balloon catheters. What is still unclear is whether resveratrol-only balloon coating in combination with a bare metal stent (BMS) also has positive effects on vascular healing. Here, we analyzed neointimal thickening, fibrin deposition, inflammation, vasa vasorum density, and reendothelialization after implantation of BMS via a resveratrol coated balloon approach in a porcine model. In general, resveratrol treatment did not result in significantly altered responses compared to the control group in peripheral arteries. In coronary arteries, an increase in vasa vasorum density became evident three days after resveratrol treatment compared to the control group and abolished up to day 7. Significant effects of the resveratrol treatment on the fibrin score or intima-media area were transient and restricted to either peripheral or coronary arteries. In conclusion, local single-dose resveratrol treatment via a resveratrol-only coated balloon and BMS approach did not lead to adverse systemic or local effects, but also no significant beneficial effects on vascular healing were detected in the current study. |
| doi_str_mv | 10.3390/ijms222313099 |
| format | Article |
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Often, balloons or stents coated with cytostatic drugs are used to prevent re-occlusion of the arteries. Resveratrol, which is known for its numerous beneficial effects on cardiovascular health, is used as an antioxidant additive on paclitaxel-coated balloon catheters. What is still unclear is whether resveratrol-only balloon coating in combination with a bare metal stent (BMS) also has positive effects on vascular healing. Here, we analyzed neointimal thickening, fibrin deposition, inflammation, vasa vasorum density, and reendothelialization after implantation of BMS via a resveratrol coated balloon approach in a porcine model. In general, resveratrol treatment did not result in significantly altered responses compared to the control group in peripheral arteries. In coronary arteries, an increase in vasa vasorum density became evident three days after resveratrol treatment compared to the control group and abolished up to day 7. Significant effects of the resveratrol treatment on the fibrin score or intima-media area were transient and restricted to either peripheral or coronary arteries. In conclusion, local single-dose resveratrol treatment via a resveratrol-only coated balloon and BMS approach did not lead to adverse systemic or local effects, but also no significant beneficial effects on vascular healing were detected in the current study.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms222313099</identifier><identifier>PMID: 34884903</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Angioplasty ; Angioplasty, Balloon - adverse effects ; Animal models ; Animals ; Antioxidants ; Balloon catheters ; Bioavailability ; Catheters ; Coatings ; Coronary artery ; Coronary vessels ; Coronary Vessels - drug effects ; Disease Models, Animal ; Drug dosages ; Drug-Eluting Stents - adverse effects ; Equipment Design ; Feasibility Studies ; Fibrin ; Fibrin - metabolism ; Healing ; Implantation ; Implants ; Inflammation ; Medical equipment ; Neointima - prevention & control ; Occlusion ; Paclitaxel ; Pharmacokinetics ; Resveratrol ; Resveratrol - administration & dosage ; Resveratrol - pharmacokinetics ; Stents ; Surgical implants ; Swine ; Thickening ; Tumor necrosis factor-TNF ; Vasa Vasorum - drug effects ; Veins & arteries ; Wound Healing - drug effects</subject><ispartof>International journal of molecular sciences, 2021-12, Vol.22 (23), p.13099</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-26d360751d74bebf07a2b68862a735bd4ab7e1802d34a7920b34c4c6cb97c09f3</citedby><cites>FETCH-LOGICAL-c415t-26d360751d74bebf07a2b68862a735bd4ab7e1802d34a7920b34c4c6cb97c09f3</cites><orcidid>0000-0002-9819-3060 ; 0000-0003-2747-8541</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657953/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657953/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34884903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamann, Stefanie</creatorcontrib><creatorcontrib>Haase, Tobias</creatorcontrib><creatorcontrib>Stolzenburg, Nicola</creatorcontrib><creatorcontrib>Löchel, Melanie</creatorcontrib><creatorcontrib>Peters-Berg, Daniel</creatorcontrib><creatorcontrib>Schütt, Denise</creatorcontrib><creatorcontrib>Schnorr, Jörg</creatorcontrib><title>Bare Metal Stents on Resveratrol-Coated Balloons in Porcine Coronary and Peripheral Arteries</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Balloon angioplasty and stent implantation are standard techniques to reopen stenotic vessels. Often, balloons or stents coated with cytostatic drugs are used to prevent re-occlusion of the arteries. Resveratrol, which is known for its numerous beneficial effects on cardiovascular health, is used as an antioxidant additive on paclitaxel-coated balloon catheters. What is still unclear is whether resveratrol-only balloon coating in combination with a bare metal stent (BMS) also has positive effects on vascular healing. Here, we analyzed neointimal thickening, fibrin deposition, inflammation, vasa vasorum density, and reendothelialization after implantation of BMS via a resveratrol coated balloon approach in a porcine model. In general, resveratrol treatment did not result in significantly altered responses compared to the control group in peripheral arteries. In coronary arteries, an increase in vasa vasorum density became evident three days after resveratrol treatment compared to the control group and abolished up to day 7. Significant effects of the resveratrol treatment on the fibrin score or intima-media area were transient and restricted to either peripheral or coronary arteries. In conclusion, local single-dose resveratrol treatment via a resveratrol-only coated balloon and BMS approach did not lead to adverse systemic or local effects, but also no significant beneficial effects on vascular healing were detected in the current study.</description><subject>Angioplasty</subject><subject>Angioplasty, Balloon - adverse effects</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Balloon catheters</subject><subject>Bioavailability</subject><subject>Catheters</subject><subject>Coatings</subject><subject>Coronary artery</subject><subject>Coronary vessels</subject><subject>Coronary Vessels - drug effects</subject><subject>Disease Models, Animal</subject><subject>Drug dosages</subject><subject>Drug-Eluting Stents - adverse effects</subject><subject>Equipment Design</subject><subject>Feasibility Studies</subject><subject>Fibrin</subject><subject>Fibrin - metabolism</subject><subject>Healing</subject><subject>Implantation</subject><subject>Implants</subject><subject>Inflammation</subject><subject>Medical equipment</subject><subject>Neointima - prevention & control</subject><subject>Occlusion</subject><subject>Paclitaxel</subject><subject>Pharmacokinetics</subject><subject>Resveratrol</subject><subject>Resveratrol - administration & dosage</subject><subject>Resveratrol - pharmacokinetics</subject><subject>Stents</subject><subject>Surgical implants</subject><subject>Swine</subject><subject>Thickening</subject><subject>Tumor necrosis factor-TNF</subject><subject>Vasa Vasorum - drug effects</subject><subject>Veins & arteries</subject><subject>Wound Healing - drug effects</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc1LXDEUxYNYHLUu3UrAjZtn8_2xEXSwWrBU-rErhLy8O_qGN8mYvBH63zdTp4O6yg33dw_ncBA6puScc0s-9fNFYYxxyom1O2ifCsYaQpTefTVP0EEpc0IYZ9LuoQkXxghL-D76feUz4K8w-gH_GCGOBaeIv0N5huzHnIZmmvwIHb7yw5BSLLiP-D7l0EfA05RT9PkP9rHD95D75WO9GvBlHusHykf0YeaHAkeb9xD9-nz9c3rb3H27-TK9vGuCoHJsmOq4IlrSTosW2hnRnrXKGMW85rLthG81UENYx4XXlpGWiyCCCq3VgdgZP0QXL7rLVbuALtQY1YZb5n5R3bnke_d2E_tH95CenVFSW8mrwNlGIKenFZTRLfoSYBh8hLQqjiliJJfGrNHTd-g8rXKs8f5RlFMlZKWaFyrkVEqG2dYMJW7dm3vTW-VPXifY0v-L4n8BXHSURA</recordid><startdate>20211203</startdate><enddate>20211203</enddate><creator>Kamann, Stefanie</creator><creator>Haase, Tobias</creator><creator>Stolzenburg, Nicola</creator><creator>Löchel, Melanie</creator><creator>Peters-Berg, Daniel</creator><creator>Schütt, Denise</creator><creator>Schnorr, Jörg</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9819-3060</orcidid><orcidid>https://orcid.org/0000-0003-2747-8541</orcidid></search><sort><creationdate>20211203</creationdate><title>Bare Metal Stents on Resveratrol-Coated Balloons in Porcine Coronary and Peripheral Arteries</title><author>Kamann, Stefanie ; 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Often, balloons or stents coated with cytostatic drugs are used to prevent re-occlusion of the arteries. Resveratrol, which is known for its numerous beneficial effects on cardiovascular health, is used as an antioxidant additive on paclitaxel-coated balloon catheters. What is still unclear is whether resveratrol-only balloon coating in combination with a bare metal stent (BMS) also has positive effects on vascular healing. Here, we analyzed neointimal thickening, fibrin deposition, inflammation, vasa vasorum density, and reendothelialization after implantation of BMS via a resveratrol coated balloon approach in a porcine model. In general, resveratrol treatment did not result in significantly altered responses compared to the control group in peripheral arteries. In coronary arteries, an increase in vasa vasorum density became evident three days after resveratrol treatment compared to the control group and abolished up to day 7. Significant effects of the resveratrol treatment on the fibrin score or intima-media area were transient and restricted to either peripheral or coronary arteries. In conclusion, local single-dose resveratrol treatment via a resveratrol-only coated balloon and BMS approach did not lead to adverse systemic or local effects, but also no significant beneficial effects on vascular healing were detected in the current study.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34884903</pmid><doi>10.3390/ijms222313099</doi><orcidid>https://orcid.org/0000-0002-9819-3060</orcidid><orcidid>https://orcid.org/0000-0003-2747-8541</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Angioplasty Angioplasty, Balloon - adverse effects Animal models Animals Antioxidants Balloon catheters Bioavailability Catheters Coatings Coronary artery Coronary vessels Coronary Vessels - drug effects Disease Models, Animal Drug dosages Drug-Eluting Stents - adverse effects Equipment Design Feasibility Studies Fibrin Fibrin - metabolism Healing Implantation Implants Inflammation Medical equipment Neointima - prevention & control Occlusion Paclitaxel Pharmacokinetics Resveratrol Resveratrol - administration & dosage Resveratrol - pharmacokinetics Stents Surgical implants Swine Thickening Tumor necrosis factor-TNF Vasa Vasorum - drug effects Veins & arteries Wound Healing - drug effects |
| title | Bare Metal Stents on Resveratrol-Coated Balloons in Porcine Coronary and Peripheral Arteries |
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