Emerging Role of TCA Cycle-Related Enzymes in Human Diseases
The tricarboxylic acid (TCA) cycle is the main source of cellular energy and participates in many metabolic pathways in cells. Recent reports indicate that dysfunction of TCA cycle-related enzymes causes human diseases, such as neurometabolic disorders and tumors, have attracted increasing interest...
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| Veröffentlicht in: | International journal of molecular sciences 2021-12, Vol.22 (23), p.13057 |
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| container_title | International journal of molecular sciences |
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| creator | Kang, Woojin Suzuki, Miki Saito, Takako Miyado, Kenji |
| description | The tricarboxylic acid (TCA) cycle is the main source of cellular energy and participates in many metabolic pathways in cells. Recent reports indicate that dysfunction of TCA cycle-related enzymes causes human diseases, such as neurometabolic disorders and tumors, have attracted increasing interest in their unexplained roles. The diseases which develop as a consequence of loss or dysfunction of TCA cycle-related enzymes are distinct, suggesting that each enzyme has a unique function. This review aims to provide a comprehensive overview of the relationship between each TCA cycle-related enzyme and human diseases. We also discuss their functions in the context of both mitochondrial and extra-mitochondrial (or cytoplasmic) enzymes. |
| doi_str_mv | 10.3390/ijms222313057 |
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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Aging - physiology Amino acids Animals Apoptosis Atrophy Breast cancer Calcium Signaling Carbon Citric Acid Cycle - physiology Clinical Trials as Topic Dehydrogenases Enzymes Enzymes - genetics Enzymes - metabolism Fatty acids Humans Kidney cancer Leukemia Metabolic Diseases - metabolism Metabolic Diseases - therapy Metabolic disorders Metabolic pathways Metabolism Mitochondria Mitochondria - metabolism Mutation Oxidation Oxidative stress Review Tricarboxylic acid cycle Tumors |
| title | Emerging Role of TCA Cycle-Related Enzymes in Human Diseases |
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