Epigenetic Mechanisms and Therapeutic Targets in Chemoresistant High-Grade Serous Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) is the most common ovarian cancer subtype, and the overall survival rate has not improved in the last three decades. Currently, most patients develop recurrent disease within 3 years and succumb to the disease within 5 years. This is an important area of rese...

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Veröffentlicht in:	Cancers 2021-11, Vol.13 (23), p.5993
Hauptverfasser:	Matthews, Bayley, Bowden, Nikola, Wong-Brown, Michelle
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2'-deoxycytidine Chemoresistance Chemotherapy Clinical trials Deacetylation Deoxyribonucleic acid DNA DNA methylation Drug development Epigenetics Histone deacetylase Metastases MicroRNAs miRNA Nucleotide sequence Ovarian cancer Patients Platinum Review Therapeutic targets
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