Clinical Response to Anti-CD47 Immunotherapy Is Associated with Rapid Reduction of Exhausted Bystander CD4+ BTLA+ T Cells in Tumor Microenvironment of Mycosis Fungoides

Cancer progression in mycosis fungoides, the most common form of cutaneous T-cell lymphoma, occurs in a predictable, sequential pattern that starts from patches and that evolves to plaques and later to tumors. Therefore, unlocking the relationship between the microarchitecture of mycosis fungoides a...

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Veröffentlicht in:	Cancers 2021-11, Vol.13 (23), p.5982
Hauptverfasser:	Jiang, Tony T., Kruglov, Oleg, Lin, Gloria H. Y., Minic, Angela, Jordan, Kimberly, Uger, Robert A., Wong, Mark, Shou, Yaping, Akilov, Oleg E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Biopsy BTLA protein Cancer CD4 antigen CD8 antigen Cell activation Cytotoxicity FDA approval Fungal infections Immune clearance Immune system Immunotherapy Inflammation Lymphocytes Lymphocytes T Lymphoma Mycosis Mycosis fungoides Patients Plaques Skin T-cell lymphoma Therapeutic applications Tumor microenvironment Tumors α-Interferon
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