Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases
Ultrafine particles (UFPs) are particles smaller than 100 nanometers that are produced unintentionally during human activities or natural phenomena. They have a higher biological reactivity than bigger particles and can reach the placenta after maternal exposure. One study has shown an association b...
Gespeichert in:
| Veröffentlicht in: | International journal of environmental research and public health 2021-12, Vol.18 (23), p.12719 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 23 |
| container_start_page | 12719 |
| container_title | International journal of environmental research and public health |
| container_volume | 18 |
| creator | Pasquiou, Anaïs Pelluard, Fanny Manangama, Guyguy Brochard, Patrick Audignon, Sabyne Sentilhes, Loïc Delva, Fleur |
| description | Ultrafine particles (UFPs) are particles smaller than 100 nanometers that are produced unintentionally during human activities or natural phenomena. They have a higher biological reactivity than bigger particles and can reach the placenta after maternal exposure. One study has shown an association between maternal occupational exposure to UFPs and fetal growth restriction. Yet few studies have focused on the effects of UFP exposure on placental histopathological lesions. The aim of this study was to investigate the association between maternal occupational exposure to UFPs and histopathological lesions of their placenta. The analyses were based on data from the ARTEMIS Center. A job-exposure matrix was used to assess occupational exposure to UFPs. The histopathological placental exam was performed by two pathologists who were blinded to the exposure of each subject. The examination was conducted in accordance with the recommendations of the Amsterdam consensus. The study sample included 130 placentas (30 exposed, 100 unexposed). Maternal occupational exposure to UFPs during pregnancy is significantly associated with placental hypoplasia (the phenomenon affected 61% of the exposed patients and 34% of the unexposed ones,
< 0.01). Further research is needed to explain its pathophysiological mechanisms. |
| doi_str_mv | 10.3390/ijerph182312719 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8656674</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2608541264</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-9b49a25de357efd913ab136469e6c7dd2521168528e7ab68a61184871a31ab363</originalsourceid><addsrcrecordid>eNpdkk1vEzEQhlcIREvhzA1Z4gKHUI-_1suhUhQVghSpFdCz5fVOGkeb9WJ7Kyr-PI5SqpKTrfHzvjPjmap6C_QT5w0991uM4wY048BqaJ5Vp6AUnQlF4fmT-0n1KqUtpVwL1bysTrjQWgkhT6s_V85No80-DLYnl7_HkKaIJAdy0-do135Acm1j9q7HROzQkeveOhxyoZc-5VC0m9CHW-9KZIWpGKXPZE6-Y44hjeiyv0PyI0_dPbFtmDIBTsnCJkyvqxdr2yd883CeVTdfLn8ulrPV1ddvi_lq5oSUeda0orFMdshljeuuAW5b4Kp0gsrVXcckA1BaMo21bZW2CkALXYPlYFuu-Fl1cfAdp3aH3b76aHszRr-z8d4E683_L4PfmNtwZ7SSStWiGHw8GGyOZMv5yuxjlEteM63uoLAfHpLF8GvClM3OJ4d9bwcMUzJMUS0FMLW3fX-EbsMUyxwOFEBDKSvU-YFy5T9TxPVjBUDNfgnM0RIUxbun_T7y_6bO_wLi-K61</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2608119002</pqid></control><display><type>article</type><title>Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Pasquiou, Anaïs ; Pelluard, Fanny ; Manangama, Guyguy ; Brochard, Patrick ; Audignon, Sabyne ; Sentilhes, Loïc ; Delva, Fleur</creator><creatorcontrib>Pasquiou, Anaïs ; Pelluard, Fanny ; Manangama, Guyguy ; Brochard, Patrick ; Audignon, Sabyne ; Sentilhes, Loïc ; Delva, Fleur</creatorcontrib><description>Ultrafine particles (UFPs) are particles smaller than 100 nanometers that are produced unintentionally during human activities or natural phenomena. They have a higher biological reactivity than bigger particles and can reach the placenta after maternal exposure. One study has shown an association between maternal occupational exposure to UFPs and fetal growth restriction. Yet few studies have focused on the effects of UFP exposure on placental histopathological lesions. The aim of this study was to investigate the association between maternal occupational exposure to UFPs and histopathological lesions of their placenta. The analyses were based on data from the ARTEMIS Center. A job-exposure matrix was used to assess occupational exposure to UFPs. The histopathological placental exam was performed by two pathologists who were blinded to the exposure of each subject. The examination was conducted in accordance with the recommendations of the Amsterdam consensus. The study sample included 130 placentas (30 exposed, 100 unexposed). Maternal occupational exposure to UFPs during pregnancy is significantly associated with placental hypoplasia (the phenomenon affected 61% of the exposed patients and 34% of the unexposed ones,
< 0.01). Further research is needed to explain its pathophysiological mechanisms.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph182312719</identifier><identifier>PMID: 34886445</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Air Pollutants - analysis ; Atoms & subatomic particles ; Diabetes ; Environmental health ; Epidemiology ; Exposure ; Female ; Fetuses ; Humans ; Hypoplasia ; Infertility ; Lesions ; Life Sciences ; Occupational exposure ; Occupational Exposure - analysis ; Occupational Exposure - statistics & numerical data ; Occupational health ; Occupational safety ; Particle Size ; Particulate Matter - analysis ; Particulate Matter - toxicity ; Patients ; Placenta ; Placenta - chemistry ; Pregnancy ; Retrospective Studies ; Risk factors ; Santé publique et épidémiologie ; Tobacco ; Ultrafines ; Womens health</subject><ispartof>International journal of environmental research and public health, 2021-12, Vol.18 (23), p.12719</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-9b49a25de357efd913ab136469e6c7dd2521168528e7ab68a61184871a31ab363</citedby><cites>FETCH-LOGICAL-c455t-9b49a25de357efd913ab136469e6c7dd2521168528e7ab68a61184871a31ab363</cites><orcidid>0000-0003-1874-2742 ; 0000-0003-2091-7214 ; 0000-0001-5594-5405</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656674/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656674/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34886445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03537286$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Pasquiou, Anaïs</creatorcontrib><creatorcontrib>Pelluard, Fanny</creatorcontrib><creatorcontrib>Manangama, Guyguy</creatorcontrib><creatorcontrib>Brochard, Patrick</creatorcontrib><creatorcontrib>Audignon, Sabyne</creatorcontrib><creatorcontrib>Sentilhes, Loïc</creatorcontrib><creatorcontrib>Delva, Fleur</creatorcontrib><title>Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Ultrafine particles (UFPs) are particles smaller than 100 nanometers that are produced unintentionally during human activities or natural phenomena. They have a higher biological reactivity than bigger particles and can reach the placenta after maternal exposure. One study has shown an association between maternal occupational exposure to UFPs and fetal growth restriction. Yet few studies have focused on the effects of UFP exposure on placental histopathological lesions. The aim of this study was to investigate the association between maternal occupational exposure to UFPs and histopathological lesions of their placenta. The analyses were based on data from the ARTEMIS Center. A job-exposure matrix was used to assess occupational exposure to UFPs. The histopathological placental exam was performed by two pathologists who were blinded to the exposure of each subject. The examination was conducted in accordance with the recommendations of the Amsterdam consensus. The study sample included 130 placentas (30 exposed, 100 unexposed). Maternal occupational exposure to UFPs during pregnancy is significantly associated with placental hypoplasia (the phenomenon affected 61% of the exposed patients and 34% of the unexposed ones,
< 0.01). Further research is needed to explain its pathophysiological mechanisms.</description><subject>Air Pollutants - analysis</subject><subject>Atoms & subatomic particles</subject><subject>Diabetes</subject><subject>Environmental health</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Female</subject><subject>Fetuses</subject><subject>Humans</subject><subject>Hypoplasia</subject><subject>Infertility</subject><subject>Lesions</subject><subject>Life Sciences</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - analysis</subject><subject>Occupational Exposure - statistics & numerical data</subject><subject>Occupational health</subject><subject>Occupational safety</subject><subject>Particle Size</subject><subject>Particulate Matter - analysis</subject><subject>Particulate Matter - toxicity</subject><subject>Patients</subject><subject>Placenta</subject><subject>Placenta - chemistry</subject><subject>Pregnancy</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Santé publique et épidémiologie</subject><subject>Tobacco</subject><subject>Ultrafines</subject><subject>Womens health</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkk1vEzEQhlcIREvhzA1Z4gKHUI-_1suhUhQVghSpFdCz5fVOGkeb9WJ7Kyr-PI5SqpKTrfHzvjPjmap6C_QT5w0991uM4wY048BqaJ5Vp6AUnQlF4fmT-0n1KqUtpVwL1bysTrjQWgkhT6s_V85No80-DLYnl7_HkKaIJAdy0-do135Acm1j9q7HROzQkeveOhxyoZc-5VC0m9CHW-9KZIWpGKXPZE6-Y44hjeiyv0PyI0_dPbFtmDIBTsnCJkyvqxdr2yd883CeVTdfLn8ulrPV1ddvi_lq5oSUeda0orFMdshljeuuAW5b4Kp0gsrVXcckA1BaMo21bZW2CkALXYPlYFuu-Fl1cfAdp3aH3b76aHszRr-z8d4E683_L4PfmNtwZ7SSStWiGHw8GGyOZMv5yuxjlEteM63uoLAfHpLF8GvClM3OJ4d9bwcMUzJMUS0FMLW3fX-EbsMUyxwOFEBDKSvU-YFy5T9TxPVjBUDNfgnM0RIUxbun_T7y_6bO_wLi-K61</recordid><startdate>20211202</startdate><enddate>20211202</enddate><creator>Pasquiou, Anaïs</creator><creator>Pelluard, Fanny</creator><creator>Manangama, Guyguy</creator><creator>Brochard, Patrick</creator><creator>Audignon, Sabyne</creator><creator>Sentilhes, Loïc</creator><creator>Delva, Fleur</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1874-2742</orcidid><orcidid>https://orcid.org/0000-0003-2091-7214</orcidid><orcidid>https://orcid.org/0000-0001-5594-5405</orcidid></search><sort><creationdate>20211202</creationdate><title>Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases</title><author>Pasquiou, Anaïs ; Pelluard, Fanny ; Manangama, Guyguy ; Brochard, Patrick ; Audignon, Sabyne ; Sentilhes, Loïc ; Delva, Fleur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-9b49a25de357efd913ab136469e6c7dd2521168528e7ab68a61184871a31ab363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Air Pollutants - analysis</topic><topic>Atoms & subatomic particles</topic><topic>Diabetes</topic><topic>Environmental health</topic><topic>Epidemiology</topic><topic>Exposure</topic><topic>Female</topic><topic>Fetuses</topic><topic>Humans</topic><topic>Hypoplasia</topic><topic>Infertility</topic><topic>Lesions</topic><topic>Life Sciences</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - analysis</topic><topic>Occupational Exposure - statistics & numerical data</topic><topic>Occupational health</topic><topic>Occupational safety</topic><topic>Particle Size</topic><topic>Particulate Matter - analysis</topic><topic>Particulate Matter - toxicity</topic><topic>Patients</topic><topic>Placenta</topic><topic>Placenta - chemistry</topic><topic>Pregnancy</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Santé publique et épidémiologie</topic><topic>Tobacco</topic><topic>Ultrafines</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pasquiou, Anaïs</creatorcontrib><creatorcontrib>Pelluard, Fanny</creatorcontrib><creatorcontrib>Manangama, Guyguy</creatorcontrib><creatorcontrib>Brochard, Patrick</creatorcontrib><creatorcontrib>Audignon, Sabyne</creatorcontrib><creatorcontrib>Sentilhes, Loïc</creatorcontrib><creatorcontrib>Delva, Fleur</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pasquiou, Anaïs</au><au>Pelluard, Fanny</au><au>Manangama, Guyguy</au><au>Brochard, Patrick</au><au>Audignon, Sabyne</au><au>Sentilhes, Loïc</au><au>Delva, Fleur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2021-12-02</date><risdate>2021</risdate><volume>18</volume><issue>23</issue><spage>12719</spage><pages>12719-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Ultrafine particles (UFPs) are particles smaller than 100 nanometers that are produced unintentionally during human activities or natural phenomena. They have a higher biological reactivity than bigger particles and can reach the placenta after maternal exposure. One study has shown an association between maternal occupational exposure to UFPs and fetal growth restriction. Yet few studies have focused on the effects of UFP exposure on placental histopathological lesions. The aim of this study was to investigate the association between maternal occupational exposure to UFPs and histopathological lesions of their placenta. The analyses were based on data from the ARTEMIS Center. A job-exposure matrix was used to assess occupational exposure to UFPs. The histopathological placental exam was performed by two pathologists who were blinded to the exposure of each subject. The examination was conducted in accordance with the recommendations of the Amsterdam consensus. The study sample included 130 placentas (30 exposed, 100 unexposed). Maternal occupational exposure to UFPs during pregnancy is significantly associated with placental hypoplasia (the phenomenon affected 61% of the exposed patients and 34% of the unexposed ones,
< 0.01). Further research is needed to explain its pathophysiological mechanisms.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34886445</pmid><doi>10.3390/ijerph182312719</doi><orcidid>https://orcid.org/0000-0003-1874-2742</orcidid><orcidid>https://orcid.org/0000-0003-2091-7214</orcidid><orcidid>https://orcid.org/0000-0001-5594-5405</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1660-4601 |
| ispartof | International journal of environmental research and public health, 2021-12, Vol.18 (23), p.12719 |
| issn | 1660-4601 1661-7827 1660-4601 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8656674 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Air Pollutants - analysis Atoms & subatomic particles Diabetes Environmental health Epidemiology Exposure Female Fetuses Humans Hypoplasia Infertility Lesions Life Sciences Occupational exposure Occupational Exposure - analysis Occupational Exposure - statistics & numerical data Occupational health Occupational safety Particle Size Particulate Matter - analysis Particulate Matter - toxicity Patients Placenta Placenta - chemistry Pregnancy Retrospective Studies Risk factors Santé publique et épidémiologie Tobacco Ultrafines Womens health |
| title | Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T18%3A13%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Occupational%20Exposure%20to%20Ultrafine%20Particles%20and%20Placental%20Histopathological%20Lesions:%20A%20Retrospective%20Study%20about%20130%20Cases&rft.jtitle=International%20journal%20of%20environmental%20research%20and%20public%20health&rft.au=Pasquiou,%20Ana%C3%AFs&rft.date=2021-12-02&rft.volume=18&rft.issue=23&rft.spage=12719&rft.pages=12719-&rft.issn=1660-4601&rft.eissn=1660-4601&rft_id=info:doi/10.3390/ijerph182312719&rft_dat=%3Cproquest_pubme%3E2608541264%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2608119002&rft_id=info:pmid/34886445&rfr_iscdi=true |