Mortality in Inflammatory Rheumatic Diseases: Lithuanian National Registry Data and Systematic Review

Despite significant improvement in survival, rheumatic diseases (RD) are associated with premature mortality rates comparable to cardiovascular and neoplastic disorders. The aim of our study was to assess mortality, causes of death, and life expectancy in an inflammatory RD retrospective cohort and...

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Veröffentlicht in:International journal of environmental research and public health 2021-11, Vol.18 (23), p.12338
Hauptverfasser: Dadonienė, Jolanta, Charukevič, Greta, Jasionytė, Gabija, Staškuvienė, Karolina, Miltinienė, Dalia
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container_issue 23
container_start_page 12338
container_title International journal of environmental research and public health
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creator Dadonienė, Jolanta
Charukevič, Greta
Jasionytė, Gabija
Staškuvienė, Karolina
Miltinienė, Dalia
description Despite significant improvement in survival, rheumatic diseases (RD) are associated with premature mortality rates comparable to cardiovascular and neoplastic disorders. The aim of our study was to assess mortality, causes of death, and life expectancy in an inflammatory RD retrospective cohort and compare those with the general population as well as with the results of previously published studies in a systematic literature review. Patients with the first-time diagnosis of inflammatory RD during 2012-2019 were identified and cross-checked for their vital status and the date of death. Sex- and age-standardized mortality ratios (SMR) as well as life expectancy for patients with inflammatory RDs were calculated. The results of a systematic literature review were included in meta-standardized mortality ratio calculations. 11,636 patients with newly diagnosed RD were identified. During a total of 43,064.34 person-years of follow-up, 950 death cases occurred. The prevailing causes of death for the total cohort were cardiovascular diseases and neoplasms. The age- and sex-adjusted SMR for the total cohort was calculated to be 1.32 (1.23; 1.40). Patients with rheumatoid arthritis if diagnosed at age 18-19 tend to live for 1.63 years less than the general population, patients with spondyloarthritis-for 2.7 years less, patients with connective tissue diseases-for almost nine years less than the general population. The findings of our study support the hypothesis that patients with RD have a higher risk of mortality and lower life expectancy than the general population.
doi_str_mv 10.3390/ijerph182312338
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subjects Adolescent
Adult
Arthritis
Cardiovascular disease
Cardiovascular diseases
Cause of Death
Connective tissue diseases
Death
Humans
Inflammatory diseases
Life Expectancy
Life span
Literature reviews
Lupus
Mortality
Neoplasms
Psoriatic arthritis
Registries
Respiratory distress syndrome
Retrospective Studies
Rheumatic Diseases
Rheumatoid arthritis
Scleroderma
Systematic review
Young Adult
title Mortality in Inflammatory Rheumatic Diseases: Lithuanian National Registry Data and Systematic Review
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