Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets

Extracellular vesicles and exomere nanoparticles are under intense investigation as sources of clinically relevant cargo. Here we report the discovery of a distinct extracellular nanoparticle, termed supermere. Supermeres are morphologically distinct from exomeres and display a markedly greater upta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature cell biology 2021-12, Vol.23 (12), p.1240-1254
Hauptverfasser:	Zhang, Qin, Jeppesen, Dennis K., Higginbotham, James N., Graves-Deal, Ramona, Trinh, Vincent Q., Ramirez, Marisol A., Sohn, Yoojin, Neininger, Abigail C., Taneja, Nilay, McKinley, Eliot T., Niitsu, Hiroaki, Cao, Zheng, Evans, Rachel, Glass, Sarah E., Ray, Kevin C., Fissell, William H., Hill, Salisha, Rose, Kristie Lindsey, Huh, Won Jae, Washington, Mary Kay, Ayers, Gregory Daniel, Burnette, Dylan T., Sharma, Shivani, Rome, Leonard H., Franklin, Jeffrey L., Lee, Youngmin A., Liu, Qi, Coffey, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 13/51 14/1 14/19 14/28 14/3 14/32 38/91 631/1647/296 631/67/70 631/80 631/80/2373 64/60 82/58 Alzheimer Disease - pathology Alzheimer's disease Angiotensin-Converting Enzyme 2 - metabolism Argonaute 2 protein Biological markers Biological properties Biological Transport - physiology Biomarkers Biomarkers - metabolism Biomedical and Life Sciences Cancer Cancer Research Cardiovascular diseases Cardiovascular Diseases - pathology Cargo Cell Biology Cell Communication - physiology Cell Line, Tumor Cell organelles COVID-19 - pathology Developmental Biology Enzymes Extracellular vesicles Extracellular Vesicles - metabolism Glycogen Glycogens Glycolysis Health aspects HeLa Cells Humans In vivo methods and tests Lactic acid Lactic Acid - metabolism Life Sciences Lipids Medical research Medicine, Experimental MicroRNAs - genetics MicroRNAs - metabolism Nanoparticles Nanoparticles - classification Nanoparticles - metabolism Neoplasms - pathology Neurodegenerative diseases Physiological aspects Protein composition Stem Cells Therapeutic applications Therapeutic targets Tumor Microenvironment Vesicles
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!