Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission

Heteroplasmic mitochondrial DNA (mtDNA) mutations are a common cause of inherited disease, but a few recurrent mutations account for the vast majority of new families. The reasons for this are not known. We studied heteroplasmic mice transmitting m.5024C>T corresponding to a human pathogenic muta...

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Veröffentlicht in:	Science advances 2021-12, Vol.7 (50), p.eabi5657
Hauptverfasser:	Zhang, Haixin, Esposito, Marco, Pezet, Mikael G, Aryaman, Juvid, Wei, Wei, Klimm, Florian, Calabrese, Claudia, Burr, Stephen P, Macabelli, Carolina H, Viscomi, Carlo, Saitou, Mitinori, Chiaratti, Marcos R, Stewart, James B, Jones, Nick, Chinnery, Patrick F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedicine and Life Sciences Diseases and Disorders Genetics SciAdv r-articles
Online-Zugang:	Volltext
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