Genetic diversity in the IZUMO1-JUNO protein-receptor pair involved in human reproduction

Fertilization in mammals begins with the union of egg and sperm, an event that starts a cascade of cellular processes. The molecular-level understanding of these processes can guide the development of new strategies for controlling and/or promoting fertilization, and inform researchers and medical p...

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Veröffentlicht in:	PloS one 2021-12, Vol.16 (12), p.e0260692-e0260692, Article 0260692
Hauptverfasser:	Allingham, Jessica, Floriano, Wely B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age groups Alleles Analysis Balancing Biological diversity Biology and Life Sciences Chromosome Mapping Chromosomes Conservation Conserved sequence Contraceptives Databases, Genetic Datasets Deviation Differentiation Ecology and Environmental Sciences Egg Proteins - chemistry Egg Proteins - genetics Egg Proteins - metabolism Eggs Evolution Evolution, Molecular Female Fertility Fertilization Gene sequencing Genes Genetic aspects Genetic diversity Genomes Haplotypes Human reproduction Humans Immunoglobulins - chemistry Immunoglobulins - genetics Immunoglobulins - metabolism Infertility Male Medical personnel Medical research Medical treatment Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Missense mutation Models, Molecular Multidisciplinary Sciences Mutation Mutation, Missense Nucleotides Population Population genetics Population studies Population-based studies Positive selection Protein Conformation Protein interaction Protein-protein interactions Proteins Receptors Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Reproduction Science & Technology Science & Technology - Other Topics Single-nucleotide polymorphism Sperm
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