A SARS‐CoV‐2 Neutralization Assay Using Single Molecule Arrays

Coronavirus disease 2019 (COVID‐19) manifests with high clinical variability and warrants sensitive and specific assays to analyze immune responses in infected and vaccinated individuals. Using Single Molecule Arrays (Simoa), we developed an assay to assess antibody neutralization with high sensitiv...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-12, Vol.60 (49), p.25966-25972
Hauptverfasser:	Gilboa, Tal, Cohen, Limor, Cheng, Chi‐An, Lazarovits, Roey, Uwamanzu‐Nna, Augusta, Han, Isaac, Griswold, Kettner, Barry, Nick, Thompson, David B., Kohman, Richie E., Woolley, Ann E., Karlson, Elizabeth W., Walt, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - immunology Angiotensin-Converting Enzyme 2 - metabolism Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antigen-Antibody Reactions Arrays Assaying Biosafety Case-Control Studies Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - pathology COVID-19 - virology COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - immunology Enzyme-Linked Immunosorbent Assay Epidemiology Humans Immune response Multiplexing Neutralization neutralization assays Neutralization Tests - methods Pandemics Patients SARS-CoV-2 - immunology SARS-CoV-2 - isolation & purification SARS-CoV-2 - metabolism Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 single molecule arrays Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism Vaccine development Vaccines Viral diseases Viruses
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