Temperature-Controlled Radiofrequency Neurolysis for the Treatment of Rhinitis
Background Chronic rhinitis is a prevalent condition with a significant impact on quality of life. Posterior nasal nerve and vidian neurectomy are surgical options for treating the symptoms of chronic rhinitis but are invasive procedures. Objective To determine the outcomes of patients diagnosed wit...
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| Veröffentlicht in: | American journal of rhinology & allergy 2022-01, Vol.36 (1), p.149-156 |
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| container_title | American journal of rhinology & allergy |
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| creator | Ehmer, Dale McDuffie, Chad M. Scurry, W. Cooper McIntyre, J. Bradley Mehendale, Neelesh H. Willis, John H. Shealy, Ronald B. Watkins, Jeremy P. Kakarlapudi, V. Vasu |
| description | Background
Chronic rhinitis is a prevalent condition with a significant impact on quality of life. Posterior nasal nerve and vidian neurectomy are surgical options for treating the symptoms of chronic rhinitis but are invasive procedures.
Objective
To determine the outcomes of patients diagnosed with refractory chronic rhinitis and treated with temperature-controlled radiofrequency neurolysis of the posterior nasal nerve area in a minimally invasive procedure.
Methods
A prospective, single-arm multicenter study with follow-up through 52 weeks. Eligible adult patients had chronic rhinitis symptoms of at least 6 months duration with inadequate response to at least 4 weeks usage of intranasal steroids and an overall 12-h reflective total nasal symptom score (rTNSS) ≥ 6 with subscores 2 to 3 for rhinorrhea, 1 to 3 for nasal congestion, and 0 to 3 for each of nasal itching and sneezing. Temperature-controlled radiofrequency energy was delivered to the nasal cavity mucosa overlying the posterior nasal nerve region with a novel single-use, disposable, handheld device.
Results
A total of 50 patients were treated (42.0% male; mean age 57.9 ± 11.9 years), and 47 completed the study through 52 weeks. Mean rTNSS significantly improved from 8.5 (95% CI 8.0, 9.0) at baseline to 3.6 (95% CI 3.0, 4.3) at 52 weeks (P |
| doi_str_mv | 10.1177/19458924211033400 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8652359</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_19458924211033400</sage_id><sourcerecordid>2560830594</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-f75059555a80d57f0932a10de3899568224cf1bdcacdc71fa5dfffb7193037b63</originalsourceid><addsrcrecordid>eNp9UU1LAzEQDaJorf4AL7JHL1vzuR8XQYpfUBRKPYc0O2lTdjc12RX6701pLYrgaYaZN--9mUHoiuARIXl-S0ouipJySghmjGN8hAbbWlqUjB4fcsrP0HkIK4wzLjg5RWeMs4JyzgfodQbNGrzqeg_p2LWdd3UNVTJVlXXGw0cPrd4kr9DHxibYkBjnk24JycyD6hpou8SZZLq0re1suEAnRtUBLvdxiN4fH2bj53Ty9vQyvp-kOip3qckFFqUQQhW4ErnB0a8iuAJWlKXICkq5NmReaaUrnROjRGWMmeekZJjl84wN0d2Od93PG6h0tOFVLdfeNspvpFNW_u60dikX7lMWmaBMlJHgZk_gXdwxdLKxQUNdqxZcHyQVGS5YNMkjlOyg2rsQPJiDDMFy-wf55w9x5vqnv8PE9-EjYLQDBLUAuXK9b-O9_mH8AmQnkfk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2560830594</pqid></control><display><type>article</type><title>Temperature-Controlled Radiofrequency Neurolysis for the Treatment of Rhinitis</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><source>Alma/SFX Local Collection</source><creator>Ehmer, Dale ; McDuffie, Chad M. ; Scurry, W. Cooper ; McIntyre, J. Bradley ; Mehendale, Neelesh H. ; Willis, John H. ; Shealy, Ronald B. ; Watkins, Jeremy P. ; Kakarlapudi, V. Vasu</creator><creatorcontrib>Ehmer, Dale ; McDuffie, Chad M. ; Scurry, W. Cooper ; McIntyre, J. Bradley ; Mehendale, Neelesh H. ; Willis, John H. ; Shealy, Ronald B. ; Watkins, Jeremy P. ; Kakarlapudi, V. Vasu</creatorcontrib><description>Background
Chronic rhinitis is a prevalent condition with a significant impact on quality of life. Posterior nasal nerve and vidian neurectomy are surgical options for treating the symptoms of chronic rhinitis but are invasive procedures.
Objective
To determine the outcomes of patients diagnosed with refractory chronic rhinitis and treated with temperature-controlled radiofrequency neurolysis of the posterior nasal nerve area in a minimally invasive procedure.
Methods
A prospective, single-arm multicenter study with follow-up through 52 weeks. Eligible adult patients had chronic rhinitis symptoms of at least 6 months duration with inadequate response to at least 4 weeks usage of intranasal steroids and an overall 12-h reflective total nasal symptom score (rTNSS) ≥ 6 with subscores 2 to 3 for rhinorrhea, 1 to 3 for nasal congestion, and 0 to 3 for each of nasal itching and sneezing. Temperature-controlled radiofrequency energy was delivered to the nasal cavity mucosa overlying the posterior nasal nerve region with a novel single-use, disposable, handheld device.
Results
A total of 50 patients were treated (42.0% male; mean age 57.9 ± 11.9 years), and 47 completed the study through 52 weeks. Mean rTNSS significantly improved from 8.5 (95% CI 8.0, 9.0) at baseline to 3.6 (95% CI 3.0, 4.3) at 52 weeks (P < .001), a 57.6% improvement. Similar trends in improvement were noted for rTNSS subscores (rhinorrhea, nasal congestion, itching, sneezing), postnasal drip scores, and chronic cough scores. Subgroup analysis demonstrated the treatment was effective regardless of rhinitis classification (allergic or nonallergic). No serious adverse events with a relationship to the device/procedure occurred.
Conclusions
Temperature-controlled radiofrequency neurolysis of the posterior nasal nerve area for the treatment of chronic rhinitis is safe and resulted in a durable improvement in the symptoms of chronic rhinitis through a 52-week follow-up. Data suggest that this novel device could be considered a minimally invasive option in the otolaryngologist's armamentarium for the treatment of chronic rhinitis.</description><identifier>ISSN: 1945-8924</identifier><identifier>EISSN: 1945-8932</identifier><identifier>DOI: 10.1177/19458924211033400</identifier><identifier>PMID: 34382444</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Administration, Intranasal ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Original ; Prospective Studies ; Quality of Life ; Rhinitis - surgery ; Temperature ; Treatment Outcome</subject><ispartof>American journal of rhinology & allergy, 2022-01, Vol.36 (1), p.149-156</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021 2021 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f75059555a80d57f0932a10de3899568224cf1bdcacdc71fa5dfffb7193037b63</citedby><cites>FETCH-LOGICAL-c438t-f75059555a80d57f0932a10de3899568224cf1bdcacdc71fa5dfffb7193037b63</cites><orcidid>0000-0001-6694-4598</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/19458924211033400$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/19458924211033400$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,21800,27905,27906,43602,43603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34382444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ehmer, Dale</creatorcontrib><creatorcontrib>McDuffie, Chad M.</creatorcontrib><creatorcontrib>Scurry, W. Cooper</creatorcontrib><creatorcontrib>McIntyre, J. Bradley</creatorcontrib><creatorcontrib>Mehendale, Neelesh H.</creatorcontrib><creatorcontrib>Willis, John H.</creatorcontrib><creatorcontrib>Shealy, Ronald B.</creatorcontrib><creatorcontrib>Watkins, Jeremy P.</creatorcontrib><creatorcontrib>Kakarlapudi, V. Vasu</creatorcontrib><title>Temperature-Controlled Radiofrequency Neurolysis for the Treatment of Rhinitis</title><title>American journal of rhinology & allergy</title><addtitle>American Journal of Rhinology & Allergy</addtitle><description>Background
Chronic rhinitis is a prevalent condition with a significant impact on quality of life. Posterior nasal nerve and vidian neurectomy are surgical options for treating the symptoms of chronic rhinitis but are invasive procedures.
Objective
To determine the outcomes of patients diagnosed with refractory chronic rhinitis and treated with temperature-controlled radiofrequency neurolysis of the posterior nasal nerve area in a minimally invasive procedure.
Methods
A prospective, single-arm multicenter study with follow-up through 52 weeks. Eligible adult patients had chronic rhinitis symptoms of at least 6 months duration with inadequate response to at least 4 weeks usage of intranasal steroids and an overall 12-h reflective total nasal symptom score (rTNSS) ≥ 6 with subscores 2 to 3 for rhinorrhea, 1 to 3 for nasal congestion, and 0 to 3 for each of nasal itching and sneezing. Temperature-controlled radiofrequency energy was delivered to the nasal cavity mucosa overlying the posterior nasal nerve region with a novel single-use, disposable, handheld device.
Results
A total of 50 patients were treated (42.0% male; mean age 57.9 ± 11.9 years), and 47 completed the study through 52 weeks. Mean rTNSS significantly improved from 8.5 (95% CI 8.0, 9.0) at baseline to 3.6 (95% CI 3.0, 4.3) at 52 weeks (P < .001), a 57.6% improvement. Similar trends in improvement were noted for rTNSS subscores (rhinorrhea, nasal congestion, itching, sneezing), postnasal drip scores, and chronic cough scores. Subgroup analysis demonstrated the treatment was effective regardless of rhinitis classification (allergic or nonallergic). No serious adverse events with a relationship to the device/procedure occurred.
Conclusions
Temperature-controlled radiofrequency neurolysis of the posterior nasal nerve area for the treatment of chronic rhinitis is safe and resulted in a durable improvement in the symptoms of chronic rhinitis through a 52-week follow-up. Data suggest that this novel device could be considered a minimally invasive option in the otolaryngologist's armamentarium for the treatment of chronic rhinitis.</description><subject>Administration, Intranasal</subject><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Rhinitis - surgery</subject><subject>Temperature</subject><subject>Treatment Outcome</subject><issn>1945-8924</issn><issn>1945-8932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp9UU1LAzEQDaJorf4AL7JHL1vzuR8XQYpfUBRKPYc0O2lTdjc12RX6701pLYrgaYaZN--9mUHoiuARIXl-S0ouipJySghmjGN8hAbbWlqUjB4fcsrP0HkIK4wzLjg5RWeMs4JyzgfodQbNGrzqeg_p2LWdd3UNVTJVlXXGw0cPrd4kr9DHxibYkBjnk24JycyD6hpou8SZZLq0re1suEAnRtUBLvdxiN4fH2bj53Ty9vQyvp-kOip3qckFFqUQQhW4ErnB0a8iuAJWlKXICkq5NmReaaUrnROjRGWMmeekZJjl84wN0d2Od93PG6h0tOFVLdfeNspvpFNW_u60dikX7lMWmaBMlJHgZk_gXdwxdLKxQUNdqxZcHyQVGS5YNMkjlOyg2rsQPJiDDMFy-wf55w9x5vqnv8PE9-EjYLQDBLUAuXK9b-O9_mH8AmQnkfk</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Ehmer, Dale</creator><creator>McDuffie, Chad M.</creator><creator>Scurry, W. Cooper</creator><creator>McIntyre, J. Bradley</creator><creator>Mehendale, Neelesh H.</creator><creator>Willis, John H.</creator><creator>Shealy, Ronald B.</creator><creator>Watkins, Jeremy P.</creator><creator>Kakarlapudi, V. Vasu</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6694-4598</orcidid></search><sort><creationdate>20220101</creationdate><title>Temperature-Controlled Radiofrequency Neurolysis for the Treatment of Rhinitis</title><author>Ehmer, Dale ; McDuffie, Chad M. ; Scurry, W. Cooper ; McIntyre, J. Bradley ; Mehendale, Neelesh H. ; Willis, John H. ; Shealy, Ronald B. ; Watkins, Jeremy P. ; Kakarlapudi, V. Vasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-f75059555a80d57f0932a10de3899568224cf1bdcacdc71fa5dfffb7193037b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Administration, Intranasal</topic><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Rhinitis - surgery</topic><topic>Temperature</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ehmer, Dale</creatorcontrib><creatorcontrib>McDuffie, Chad M.</creatorcontrib><creatorcontrib>Scurry, W. Cooper</creatorcontrib><creatorcontrib>McIntyre, J. Bradley</creatorcontrib><creatorcontrib>Mehendale, Neelesh H.</creatorcontrib><creatorcontrib>Willis, John H.</creatorcontrib><creatorcontrib>Shealy, Ronald B.</creatorcontrib><creatorcontrib>Watkins, Jeremy P.</creatorcontrib><creatorcontrib>Kakarlapudi, V. Vasu</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of rhinology & allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ehmer, Dale</au><au>McDuffie, Chad M.</au><au>Scurry, W. Cooper</au><au>McIntyre, J. Bradley</au><au>Mehendale, Neelesh H.</au><au>Willis, John H.</au><au>Shealy, Ronald B.</au><au>Watkins, Jeremy P.</au><au>Kakarlapudi, V. Vasu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temperature-Controlled Radiofrequency Neurolysis for the Treatment of Rhinitis</atitle><jtitle>American journal of rhinology & allergy</jtitle><addtitle>American Journal of Rhinology & Allergy</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>36</volume><issue>1</issue><spage>149</spage><epage>156</epage><pages>149-156</pages><issn>1945-8924</issn><eissn>1945-8932</eissn><abstract>Background
Chronic rhinitis is a prevalent condition with a significant impact on quality of life. Posterior nasal nerve and vidian neurectomy are surgical options for treating the symptoms of chronic rhinitis but are invasive procedures.
Objective
To determine the outcomes of patients diagnosed with refractory chronic rhinitis and treated with temperature-controlled radiofrequency neurolysis of the posterior nasal nerve area in a minimally invasive procedure.
Methods
A prospective, single-arm multicenter study with follow-up through 52 weeks. Eligible adult patients had chronic rhinitis symptoms of at least 6 months duration with inadequate response to at least 4 weeks usage of intranasal steroids and an overall 12-h reflective total nasal symptom score (rTNSS) ≥ 6 with subscores 2 to 3 for rhinorrhea, 1 to 3 for nasal congestion, and 0 to 3 for each of nasal itching and sneezing. Temperature-controlled radiofrequency energy was delivered to the nasal cavity mucosa overlying the posterior nasal nerve region with a novel single-use, disposable, handheld device.
Results
A total of 50 patients were treated (42.0% male; mean age 57.9 ± 11.9 years), and 47 completed the study through 52 weeks. Mean rTNSS significantly improved from 8.5 (95% CI 8.0, 9.0) at baseline to 3.6 (95% CI 3.0, 4.3) at 52 weeks (P < .001), a 57.6% improvement. Similar trends in improvement were noted for rTNSS subscores (rhinorrhea, nasal congestion, itching, sneezing), postnasal drip scores, and chronic cough scores. Subgroup analysis demonstrated the treatment was effective regardless of rhinitis classification (allergic or nonallergic). No serious adverse events with a relationship to the device/procedure occurred.
Conclusions
Temperature-controlled radiofrequency neurolysis of the posterior nasal nerve area for the treatment of chronic rhinitis is safe and resulted in a durable improvement in the symptoms of chronic rhinitis through a 52-week follow-up. Data suggest that this novel device could be considered a minimally invasive option in the otolaryngologist's armamentarium for the treatment of chronic rhinitis.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>34382444</pmid><doi>10.1177/19458924211033400</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6694-4598</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1945-8924 |
| ispartof | American journal of rhinology & allergy, 2022-01, Vol.36 (1), p.149-156 |
| issn | 1945-8924 1945-8932 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8652359 |
| source | MEDLINE; SAGE Complete A-Z List; Alma/SFX Local Collection |
| subjects | Administration, Intranasal Adult Aged Female Humans Male Middle Aged Original Prospective Studies Quality of Life Rhinitis - surgery Temperature Treatment Outcome |
| title | Temperature-Controlled Radiofrequency Neurolysis for the Treatment of Rhinitis |
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