Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients
Malignant mesothelioma is a neoplasm of serosal surfaces, most commonly affecting the pleura. The peritoneum, pericardium, and tunica vaginalis are less frequently involved. Malignant mesothelioma with EWSR1-ATF1 fusion in young adults was recently reported in the literature. Here, we present two pe...
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| Veröffentlicht in: | Pediatric and developmental pathology 2021-11, Vol.24 (6), p.570-574 |
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| creator | Ren, Hezhen Rassekh, S Rod Lacson, Atilano Lee, Cheng-Han Dickson, Brendan C Chung, Catherine T Lee, Anna F |
| description | Malignant mesothelioma is a neoplasm of serosal surfaces, most commonly affecting the pleura. The peritoneum, pericardium, and tunica vaginalis are less frequently involved. Malignant mesothelioma with EWSR1-ATF1 fusion in young adults was recently reported in the literature. Here, we present two pediatric cases of EWSR1-ATF1 translocation-associated malignant mesothelioma in the peritoneum and pericardium respectively. Both cases lacked a known exposure history. Microscopy in both cases showed predominantly epithelioid morphology with ample eosinophilic cytoplasm, and immunohistochemistry was positive for pan-keratin, calretinin, and WT1. Both cases showed EWSR1-ATF1 gene rearrangement by RNA sequencing, which was instrumental in confirming the diagnosis of malignant mesothelioma and to exclude more common pediatric sarcomas, especially in the context of limited sampling. |
| doi_str_mv | 10.1177/10935266211021222 |
| format | Article |
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The peritoneum, pericardium, and tunica vaginalis are less frequently involved. Malignant mesothelioma with EWSR1-ATF1 fusion in young adults was recently reported in the literature. Here, we present two pediatric cases of EWSR1-ATF1 translocation-associated malignant mesothelioma in the peritoneum and pericardium respectively. Both cases lacked a known exposure history. Microscopy in both cases showed predominantly epithelioid morphology with ample eosinophilic cytoplasm, and immunohistochemistry was positive for pan-keratin, calretinin, and WT1. Both cases showed EWSR1-ATF1 gene rearrangement by RNA sequencing, which was instrumental in confirming the diagnosis of malignant mesothelioma and to exclude more common pediatric sarcomas, especially in the context of limited sampling.</description><identifier>ISSN: 1093-5266</identifier><identifier>EISSN: 1615-5742</identifier><identifier>DOI: 10.1177/10935266211021222</identifier><identifier>PMID: 34121509</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Case Reports ; Child ; Gene Fusion ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Male ; Mesothelioma - diagnosis ; Mesothelioma - genetics ; Mesothelioma, Malignant ; Oncogene Proteins, Fusion - genetics ; RNA-Binding Protein EWS - genetics ; Young Adult</subject><ispartof>Pediatric and developmental pathology, 2021-11, Vol.24 (6), p.570-574</ispartof><rights>2021, Society for Pediatric Pathology All rights reserved</rights><rights>2021, Society for Pediatric Pathology All rights reserved 2021 Society of Pediatric Pathology. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-e27262ad69a3d54ee94f0c98ed0e03101ceef5c6214a925e5f7eb89a2ea132a63</citedby><cites>FETCH-LOGICAL-c438t-e27262ad69a3d54ee94f0c98ed0e03101ceef5c6214a925e5f7eb89a2ea132a63</cites><orcidid>0000-0002-2779-7297 ; 0000-0002-6703-0656</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/10935266211021222$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/10935266211021222$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34121509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Hezhen</creatorcontrib><creatorcontrib>Rassekh, S Rod</creatorcontrib><creatorcontrib>Lacson, Atilano</creatorcontrib><creatorcontrib>Lee, Cheng-Han</creatorcontrib><creatorcontrib>Dickson, Brendan C</creatorcontrib><creatorcontrib>Chung, Catherine T</creatorcontrib><creatorcontrib>Lee, Anna F</creatorcontrib><title>Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients</title><title>Pediatric and developmental pathology</title><addtitle>Pediatr Dev Pathol</addtitle><description>Malignant mesothelioma is a neoplasm of serosal surfaces, most commonly affecting the pleura. The peritoneum, pericardium, and tunica vaginalis are less frequently involved. Malignant mesothelioma with EWSR1-ATF1 fusion in young adults was recently reported in the literature. Here, we present two pediatric cases of EWSR1-ATF1 translocation-associated malignant mesothelioma in the peritoneum and pericardium respectively. Both cases lacked a known exposure history. Microscopy in both cases showed predominantly epithelioid morphology with ample eosinophilic cytoplasm, and immunohistochemistry was positive for pan-keratin, calretinin, and WT1. Both cases showed EWSR1-ATF1 gene rearrangement by RNA sequencing, which was instrumental in confirming the diagnosis of malignant mesothelioma and to exclude more common pediatric sarcomas, especially in the context of limited sampling.</description><subject>Adolescent</subject><subject>Case Reports</subject><subject>Child</subject><subject>Gene Fusion</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Male</subject><subject>Mesothelioma - diagnosis</subject><subject>Mesothelioma - genetics</subject><subject>Mesothelioma, Malignant</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>RNA-Binding Protein EWS - genetics</subject><subject>Young Adult</subject><issn>1093-5266</issn><issn>1615-5742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU1P4zAQhi3Eiu8fwAXlyCXgGdtJc0GqUAtIVLvaLeJoDcmkNUpjiBMQ_x5XBbSrlTiNR_O8r-dDiGOQZwB5fg6yUAazDAEkAiJuiT3IwKQm17gd37GeroFdsR_Co5RRlMkdsas0IBhZ7InZjBq3aKntkxkH3y-5cX5Fyb3rl8nk_s9vSMfzKSTTITjfJq5N5q8-GVe-4VDyWkUNJ7-odzEJh-JHTU3go494IO6mk_nldXr78-rmcnybllqN-pQxxwypygpSldHMha5lWYy4kiwVSCiZa1PGuTQVaNjUOT-MCkImUEiZOhAXG9-n4WHF1bqRjhr71LkVdW_Wk7P_Vlq3tAv_YkeZQWV0NDj9MOj888ChtysX52kaatkPwaLRMkelpYwobNCy8yF0XH99A9Kuz2D_O0PUnPzd35fic-8RONsAgRZsH_3QtXFf3zi-Aw_ejx8</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Ren, Hezhen</creator><creator>Rassekh, S Rod</creator><creator>Lacson, Atilano</creator><creator>Lee, Cheng-Han</creator><creator>Dickson, Brendan C</creator><creator>Chung, Catherine T</creator><creator>Lee, Anna F</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2779-7297</orcidid><orcidid>https://orcid.org/0000-0002-6703-0656</orcidid></search><sort><creationdate>20211101</creationdate><title>Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients</title><author>Ren, Hezhen ; Rassekh, S Rod ; Lacson, Atilano ; Lee, Cheng-Han ; Dickson, Brendan C ; Chung, Catherine T ; Lee, Anna F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-e27262ad69a3d54ee94f0c98ed0e03101ceef5c6214a925e5f7eb89a2ea132a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Case Reports</topic><topic>Child</topic><topic>Gene Fusion</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Male</topic><topic>Mesothelioma - diagnosis</topic><topic>Mesothelioma - genetics</topic><topic>Mesothelioma, Malignant</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>RNA-Binding Protein EWS - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Hezhen</creatorcontrib><creatorcontrib>Rassekh, S Rod</creatorcontrib><creatorcontrib>Lacson, Atilano</creatorcontrib><creatorcontrib>Lee, Cheng-Han</creatorcontrib><creatorcontrib>Dickson, Brendan C</creatorcontrib><creatorcontrib>Chung, Catherine T</creatorcontrib><creatorcontrib>Lee, Anna F</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric and developmental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Hezhen</au><au>Rassekh, S Rod</au><au>Lacson, Atilano</au><au>Lee, Cheng-Han</au><au>Dickson, Brendan C</au><au>Chung, Catherine T</au><au>Lee, Anna F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients</atitle><jtitle>Pediatric and developmental pathology</jtitle><addtitle>Pediatr Dev Pathol</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>24</volume><issue>6</issue><spage>570</spage><epage>574</epage><pages>570-574</pages><issn>1093-5266</issn><eissn>1615-5742</eissn><abstract>Malignant mesothelioma is a neoplasm of serosal surfaces, most commonly affecting the pleura. The peritoneum, pericardium, and tunica vaginalis are less frequently involved. Malignant mesothelioma with EWSR1-ATF1 fusion in young adults was recently reported in the literature. Here, we present two pediatric cases of EWSR1-ATF1 translocation-associated malignant mesothelioma in the peritoneum and pericardium respectively. Both cases lacked a known exposure history. Microscopy in both cases showed predominantly epithelioid morphology with ample eosinophilic cytoplasm, and immunohistochemistry was positive for pan-keratin, calretinin, and WT1. 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| subjects | Adolescent Case Reports Child Gene Fusion Humans Immunohistochemistry In Situ Hybridization, Fluorescence Male Mesothelioma - diagnosis Mesothelioma - genetics Mesothelioma, Malignant Oncogene Proteins, Fusion - genetics RNA-Binding Protein EWS - genetics Young Adult |
| title | Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients |
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