Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells

Flavonoids are bioactive secondary metabolites of plants, which exert anti‐cancer effects. However, metabolism in enterocytes and the liver can influence the biological activity of flavonoids contained in the diet. Therefore, results from in vitro studies on cancer cells from the digestive tract and...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2021-12, Vol.25 (24), p.11085-11096
Hauptverfasser:	Szoka, Lukasz, Nazaruk, Jolanta, Stocki, Marcin, Isidorov, Valery
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Autophagy Betula Betula - chemistry Betula pendula Betula pubescens Biological activity Buds Calibration Caspase Cell cycle Cell Line, Tumor Cell Survival - drug effects Chromatography cirsimaritin Colorectal cancer Cytotoxicity Digestive System Neoplasms Dose-Response Relationship, Drug Enterocytes Fibroblasts - drug effects Fibroblasts - metabolism Flavones - chemistry Flavones - pharmacology Flavonoids Flavonoids - chemistry Flavonoids - pharmacology Gastrointestinal tract Hepatocytes Humans Liver cancer Molecular Structure Original Plant Extracts - chemistry Plant Extracts - pharmacology santin Secondary metabolites
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