Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma

Deregulation of HOX transcription factor family has frequently been observed in multiple human cancers; however, their role in nasopharyngeal carcinoma remains largely unclear. In the present study, we found that HOX gene family is consistently upregulated in nasopharyngeal carcinoma and identified...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2021-12, Vol.246 (23), p.2454-2462
Hauptverfasser:	Gong, Dan, Zhu, Hui, Zeng, Lei, Hu, Ronghuan, Hu, Jiali, Ding, Jianwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism Carcinogenesis - genetics Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Cyclin-Dependent Kinase Inhibitor p27 - metabolism Homeobox A10 Proteins - genetics Homeobox A10 Proteins - metabolism Humans Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Nasopharyngeal Carcinoma - genetics Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - pathology Original Research RNA Interference RNA, Small Interfering - genetics S-Phase Kinase-Associated Proteins - genetics S-Phase Kinase-Associated Proteins - metabolism TOR Serine-Threonine Kinases - metabolism Transcriptional Activation - genetics Up-Regulation - genetics
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