Relevance of HLA gene polymorphisms in Romanian patients with chronic renal insufficiency undergoing renal transplantation

Background Chronic renal insufficiency (CRI) is a global public health problem with a high incidence in the Romanian population. In this study, we aimed to investigate genomic HLA polymorphisms in Romanian patients with CRI waiting for kidney transplantation. To determine the existence of a potentia...

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Veröffentlicht in:	Journal of clinical laboratory analysis 2021-12, Vol.35 (12), p.e24075-n/a
Hauptverfasser:	Mărunţelu, Ion, Cristea, Bogdan Mihai, Omer, Secil, Preda, Carmen Monica, Constantinescu, Ileana
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Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Case-Control Studies Child Child, Preschool combined HLA types CRI Disease disease‐associated HLA genes Drb1 protein Expected values Female Gene Frequency Gene polymorphism Genes Genotype & phenotype Haplotypes Health care Histocompatibility antigen HLA HLA Antigens - genetics Humans Kidney Transplantation Kidney transplants Male Middle Aged Polymerase chain reaction Polymorphism, Genetic polymorphisms Population Population studies Public health Renal insufficiency Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - therapy Romania Young Adult
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creator	Mărunţelu, Ion Cristea, Bogdan Mihai Omer, Secil Preda, Carmen Monica Constantinescu, Ileana
description	Background Chronic renal insufficiency (CRI) is a global public health problem with a high incidence in the Romanian population. In this study, we aimed to investigate genomic HLA polymorphisms in Romanian patients with CRI waiting for kidney transplantation. To determine the existence of a potential strong link between certain HLA polymorphisms and CRI, we also looked at HLA specificity combinations within the same locus or even different loci, referring to randomly inherited allelic combinations rather than potential haplotypes. Methods A total of 2199 patients with CRI on the kidney transplantation waiting list were included. A total of 2786 healthy individuals were included as controls. Both patients and controls were assessed for both HLA I and class II genes. HLA genes were typed using the low‐resolution method polymerase chain reaction sequence‐specific primer. Results Certain class I and class II HLA allele groups, genotypes and haplotypes were significantly more frequent in patients with CRI than in the control individuals (eg B* 40 (p ≤ .001, pc ≤ .001), C* 12 (p ≤ .001, pc ≤ .001), DRB114 (p = .0022, pc = .04), C12,‐ (p
doi_str_mv	10.1002/jcla.24075
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In this study, we aimed to investigate genomic HLA polymorphisms in Romanian patients with CRI waiting for kidney transplantation. To determine the existence of a potential strong link between certain HLA polymorphisms and CRI, we also looked at HLA specificity combinations within the same locus or even different loci, referring to randomly inherited allelic combinations rather than potential haplotypes. Methods A total of 2199 patients with CRI on the kidney transplantation waiting list were included. A total of 2786 healthy individuals were included as controls. Both patients and controls were assessed for both HLA I and class II genes. HLA genes were typed using the low‐resolution method polymerase chain reaction sequence‐specific primer. Results Certain class I and class II HLA allele groups, genotypes and haplotypes were significantly more frequent in patients with CRI than in the control individuals (eg B* 40 (p ≤ .001, pc ≤ .001), C* 12 (p ≤ .001, pc ≤ .001), DRB114 (p = .0022, pc = .04), C12,‐ (p < .001, pc < .001), A01‐C15 (p = .0003, pc = .03) and A02‐C12 (p = .0005, pc = .0486)). Conclusions HLA gene polymorphisms could be clinically relevant CRI‐associated genetic profiles in Romanian patients with CRI. Chronic renal insufficiency and HLA</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.24075</identifier><identifier>PMID: 34704282</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Child ; Child, Preschool ; combined HLA types ; CRI ; Disease ; disease‐associated HLA genes ; Drb1 protein ; Expected values ; Female ; Gene Frequency ; Gene polymorphism ; Genes ; Genotype & phenotype ; Haplotypes ; Health care ; Histocompatibility antigen HLA ; HLA Antigens - genetics ; Humans ; Kidney Transplantation ; Kidney transplants ; Male ; Middle Aged ; Polymerase chain reaction ; Polymorphism, Genetic ; polymorphisms ; Population ; Population studies ; Public health ; Renal insufficiency ; Renal Insufficiency, Chronic - genetics ; Renal Insufficiency, Chronic - therapy ; Romania ; Young Adult</subject><ispartof>Journal of clinical laboratory analysis, 2021-12, Vol.35 (12), p.e24075-n/a</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC.</rights><rights>2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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In this study, we aimed to investigate genomic HLA polymorphisms in Romanian patients with CRI waiting for kidney transplantation. To determine the existence of a potential strong link between certain HLA polymorphisms and CRI, we also looked at HLA specificity combinations within the same locus or even different loci, referring to randomly inherited allelic combinations rather than potential haplotypes. Methods A total of 2199 patients with CRI on the kidney transplantation waiting list were included. A total of 2786 healthy individuals were included as controls. Both patients and controls were assessed for both HLA I and class II genes. HLA genes were typed using the low‐resolution method polymerase chain reaction sequence‐specific primer. Results Certain class I and class II HLA allele groups, genotypes and haplotypes were significantly more frequent in patients with CRI than in the control individuals (eg B* 40 (p ≤ .001, pc ≤ .001), C* 12 (p ≤ .001, pc ≤ .001), DRB114 (p = .0022, pc = .04), C12,‐ (p < .001, pc < .001), A01‐C15 (p = .0003, pc = .03) and A02‐C12 (p = .0005, pc = .0486)). Conclusions HLA gene polymorphisms could be clinically relevant CRI‐associated genetic profiles in Romanian patients with CRI. Chronic renal insufficiency and HLA</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>combined HLA types</subject><subject>CRI</subject><subject>Disease</subject><subject>disease‐associated HLA genes</subject><subject>Drb1 protein</subject><subject>Expected values</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genotype & phenotype</subject><subject>Haplotypes</subject><subject>Health care</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA Antigens - genetics</subject><subject>Humans</subject><subject>Kidney Transplantation</subject><subject>Kidney transplants</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Genetic</subject><subject>polymorphisms</subject><subject>Population</subject><subject>Population studies</subject><subject>Public health</subject><subject>Renal insufficiency</subject><subject>Renal Insufficiency, Chronic - genetics</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Romania</subject><subject>Young Adult</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90UFrFDEUB_Agil2rFz-ABLwUYdokk5kkF2FZ1FoWCkXPIZO-2c2SScZkpmX99KbuWqwHTzm8H3_eyx-ht5ScU0LYxc56c844Ec0ztKBEyYpJ1jxHCyKlqCSh9Ql6lfOOECIVbV-ik5oLwgtaoJ834OHOBAs49vhyvcQbCIDH6PdDTOPW5SFjF_BNHExwJuDRTA7ClPG9m7bYblMMzuIEwfji8tz3zhZg93gOt5A20YXNcTwlE_LoTZhKRgyv0Yve-Axvju8p-v7507fVZbW-_vJ1tVxXlnPZVLVUXHBOe9p3QkmwrTCGMyBcdtArKRsiZEeVFUo0xDBuJe04MOgE7Szp6lP08ZA7zt0At7Zsn4zXY3KDSXsdjdNPJ8Ft9SbeadlyVde8BJwdA1L8MUOe9OCyBV8ugThnzRopyt-2pC70_T90F-dUji-qJYKylila1IeDsinmnKB_XIYS_VCpfqhU_6604Hd_r_9I_3RYAD2Ae-dh_58ofbVaLw-hvwCWZq6K</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Mărunţelu, Ion</creator><creator>Cristea, Bogdan Mihai</creator><creator>Omer, Secil</creator><creator>Preda, Carmen Monica</creator><creator>Constantinescu, Ileana</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5828-2694</orcidid></search><sort><creationdate>202112</creationdate><title>Relevance of HLA gene polymorphisms in Romanian patients with chronic renal insufficiency undergoing renal transplantation</title><author>Mărunţelu, Ion ; Cristea, Bogdan Mihai ; Omer, Secil ; Preda, Carmen Monica ; Constantinescu, Ileana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4485-38947441f1fb798ec67aa42e048bef9885078b19c79750a24c81b4e2eb71bc0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>combined HLA types</topic><topic>CRI</topic><topic>Disease</topic><topic>disease‐associated HLA genes</topic><topic>Drb1 protein</topic><topic>Expected values</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genotype & phenotype</topic><topic>Haplotypes</topic><topic>Health care</topic><topic>Histocompatibility antigen HLA</topic><topic>HLA Antigens - genetics</topic><topic>Humans</topic><topic>Kidney Transplantation</topic><topic>Kidney transplants</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism, Genetic</topic><topic>polymorphisms</topic><topic>Population</topic><topic>Population studies</topic><topic>Public health</topic><topic>Renal insufficiency</topic><topic>Renal Insufficiency, Chronic - genetics</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>Romania</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mărunţelu, Ion</creatorcontrib><creatorcontrib>Cristea, Bogdan Mihai</creatorcontrib><creatorcontrib>Omer, Secil</creatorcontrib><creatorcontrib>Preda, Carmen Monica</creatorcontrib><creatorcontrib>Constantinescu, Ileana</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mărunţelu, Ion</au><au>Cristea, Bogdan Mihai</au><au>Omer, Secil</au><au>Preda, Carmen Monica</au><au>Constantinescu, Ileana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relevance of HLA gene polymorphisms in Romanian patients with chronic renal insufficiency undergoing renal transplantation</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J Clin Lab Anal</addtitle><date>2021-12</date><risdate>2021</risdate><volume>35</volume><issue>12</issue><spage>e24075</spage><epage>n/a</epage><pages>e24075-n/a</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>Background Chronic renal insufficiency (CRI) is a global public health problem with a high incidence in the Romanian population. In this study, we aimed to investigate genomic HLA polymorphisms in Romanian patients with CRI waiting for kidney transplantation. To determine the existence of a potential strong link between certain HLA polymorphisms and CRI, we also looked at HLA specificity combinations within the same locus or even different loci, referring to randomly inherited allelic combinations rather than potential haplotypes. Methods A total of 2199 patients with CRI on the kidney transplantation waiting list were included. A total of 2786 healthy individuals were included as controls. Both patients and controls were assessed for both HLA I and class II genes. HLA genes were typed using the low‐resolution method polymerase chain reaction sequence‐specific primer. Results Certain class I and class II HLA allele groups, genotypes and haplotypes were significantly more frequent in patients with CRI than in the control individuals (eg B* 40 (p ≤ .001, pc ≤ .001), C* 12 (p ≤ .001, pc ≤ .001), DRB114 (p = .0022, pc = .04), C12,‐ (p < .001, pc < .001), A01‐C15 (p = .0003, pc = .03) and A02‐C12 (p = .0005, pc = .0486)). Conclusions HLA gene polymorphisms could be clinically relevant CRI‐associated genetic profiles in Romanian patients with CRI. Chronic renal insufficiency and HLA</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>34704282</pmid><doi>10.1002/jcla.24075</doi><tpages>0</tpages><orcidid>https://orcid.org/0000-0001-5828-2694</orcidid><oa>free_for_read</oa></addata></record>
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subjects	Adolescent Adult Aged Aged, 80 and over Case-Control Studies Child Child, Preschool combined HLA types CRI Disease disease‐associated HLA genes Drb1 protein Expected values Female Gene Frequency Gene polymorphism Genes Genotype & phenotype Haplotypes Health care Histocompatibility antigen HLA HLA Antigens - genetics Humans Kidney Transplantation Kidney transplants Male Middle Aged Polymerase chain reaction Polymorphism, Genetic polymorphisms Population Population studies Public health Renal insufficiency Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - therapy Romania Young Adult
title	Relevance of HLA gene polymorphisms in Romanian patients with chronic renal insufficiency undergoing renal transplantation
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