Tranexamic acid use in pelvic and/or acetabular fracture surgery: A systematic review and meta-analysis

The purpose of this study is to determine whether tranexamic acid (TXA) use was associated with lower rates of blood transfusion in patients undergoing pelvic and/or acetabular fracture surgery. Four studies were included, 3 of which were included in the pooled data analysis for a total of 308 patients. The transfusion rate was significantly lower in the TXA group (44%) compared with the non-TXA group (57%) (P = 0.02). TXA use was associated with a significantly lower transfusion rate in patients who underwent pelvic and/or acetabular fracture surgery. Level 3. Systematic review of retrospective cohort studies and prospective randomized controlled trials. •TXA use was associated with a lower transfusion rate in patients who underwent pelvic and/or acetabular fracture surgery.•No association was found between TXA use and intraoperative blood loss.•TXA use was not associated with higher rates of venous thromboembolism.