Versatile Analysis of DNA–Biomolecule Interactions in Solution by Hydrodynamic Separation and Single Molecule Detection

DNA can interact with a wide array of molecules with a range of binding affinities, stoichiometry, and size-scales. We present a sensitive, quantitative, and versatile platform for sensing and evaluating these diverse DNA–biomolecule interactions and DNA conformational changes in free solution. Sing...

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Veröffentlicht in:	Analytical chemistry (Washington) 2019-02, Vol.91 (4), p.2822-2830
Hauptverfasser:	Friedrich, Sarah M, Bang, Rachel, Li, Andrew, Wang, Tza-Huei
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Biomolecules Chemistry Competition Cooperativity Deoxyribonucleic acid DNA E coli Globules Mobility Protein interaction Proteins Quantitative analysis Separation Spermidine Stoichiometry
Online-Zugang:	Volltext
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