Individualized VDJ recombination predisposes the available Ig sequence space

The process of recombination between variable (V), diversity (D), and joining (J) immunoglobulin (Ig) gene segments determines an individual's naive Ig repertoire and, consequently, (auto)antigen recognition. VDJ recombination follows probabilistic rules that can be modeled statistically. So fa...

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Veröffentlicht in:	Genome research 2021-12, Vol.31 (12), p.2209-2224
Hauptverfasser:	Slabodkin, Andrei, Chernigovskaya, Maria, Mikocziova, Ivana, Akbar, Rahmad, Scheffer, Lonneke, Pavlović, Milena, Bashour, Habib, Snapkov, Igor, Mehta, Brij Bhushan, Weber, Cédric R, Gutierrez-Marcos, Jose, Sollid, Ludvig M, Haff, Ingrid Hobæk, Sandve, Geir Kjetil, Robert, Philippe A, Greiff, Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Autoimmunity Immunoglobulins Inbreeding Statistical analysis V(D)J recombination Vaccination
Online-Zugang:	Volltext
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