Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells

Xanthones from the tropical fruit mangosteen (Garcinia mangostana) display anti-inflammatory and anti-oxidative activities. Here, we isolate and identify potential inducers of the aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways from mangostee...

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Veröffentlicht in:	Free radical biology & medicine 2021-02, Vol.163, p.102-115
Hauptverfasser:	Tocmo, Restituto, Le, Bryan, Heun, Amber, van Pijkeren, Jan Peter, Parkin, Kirk, Johnson, Jeremy James
Format:	Artikel
Sprache:	eng
Schlagworte:	AhR receptor Fruit Garcinia mangostana Garcinone D HT29 Cells Humans Mangosteen NF-E2-Related Factor 2 - genetics Nrf2 Plant Extracts - pharmacology Receptors, Aryl Hydrocarbon - genetics Tight junction Xanthones Xanthones - pharmacology
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