Selective and Marked Blockade of Endothelial Sprouting Behavior Using Paclitaxel and Related Pharmacologic Agents

Whether alterations in the microtubule cytoskeleton affect the ability of endothelial cells (ECs) to sprout and form branching networks of tubes was investigated in this study. Bioassays of human EC tubulogenesis, where both sprouting behavior and lumen formation can be rigorously evaluated, were us...

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Veröffentlicht in:	The American journal of pathology 2021-12, Vol.191 (12), p.2245-2264
Hauptverfasser:	Lin, Prisca K., Salvador, Jocelynda, Xie, Jun, Aguera, Kalia N., Koller, Gretchen M., Kemp, Scott S., Griffin, Courtney T., Davis, George E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Blood Vessels - drug effects Blood Vessels - growth & development Cells, Cultured Docetaxel - pharmacology Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - physiology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - growth & development Epothilones - pharmacology Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - physiology Humans Mice Mice, Inbred C57BL Morphogenesis - drug effects Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Neovascularization, Physiologic - drug effects Paclitaxel - analogs & derivatives Paclitaxel - pharmacology Regular
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