Lysosomal degradation of the maternal dorsal determinant Hwa safeguards dorsal body axis formation

The Spemann and Mangold Organizer (SMO) is of fundamental importance for dorsal ventral body axis formation during vertebrate embryogenesis. Maternal Huluwa (Hwa) has been identified as the dorsal determinant that is both necessary and sufficient for SMO formation. However, it remains unclear how Hw...

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Veröffentlicht in:	EMBO reports 2021-12, Vol.22 (12), p.e53185-n/a
Hauptverfasser:	Zhu, Xuechen, Wang, Pan, Wei, Jiale, Li, Yongyu, Zhai, Jiayu, Zheng, Tianrui, Tao, Qinghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Patterning Degradation Ectopic expression EMBO11 EMBO31 EMBO37 Embryogenesis Embryonic Development Embryonic growth stage Embryos Gene Expression Regulation, Developmental Hwa Lysosomes Lysosomes - metabolism Organizers, Embryonic - metabolism Perturbation Protein transport Spemann and Mangold organizer Substrates Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism ubiquitination Vertebrates Xenopus laevis Xenopus laevis - metabolism Xenopus Proteins - genetics Xenopus Proteins - metabolism ZNRF3
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