The unfolded protein response links tumor aneuploidy to local immune dysregulation

Aneuploidy is a chromosomal abnormality associated with poor prognosis in many cancer types. Here, we tested the hypothesis that the unfolded protein response (UPR) mechanistically links aneuploidy and local immune dysregulation. Using a single somatic copy number alteration (SCNA) score inclusive o...

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Veröffentlicht in:	EMBO reports 2021-12, Vol.22 (12), p.e52509-n/a
Hauptverfasser:	Xian, Su, Dosset, Magalie, Almanza, Gonzalo, Searles, Stephen, Sahani, Paras, Waller, T Cameron, Jepsen, Kristen, Carter, Hannah, Zanetti, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Arginase Bone marrow Cancer Cell activation Chromosome aberrations Chromosomes Copy number Cytotoxicity EMBO03 EMBO19 EMBO32 Gene expression Genomes Granzyme B Humans Immune system Inflammation Interferon Links Lymphocytes Lymphocytes T Macrophages Neoplasms - genetics Phenotypes Protein folding Proteins Solid tumors Splicing T cells Termination factors Toxic diseases Toxicity Transcription Tumor cells tumor immune microenvironment Tumor Microenvironment Tumors Unfolded Protein Response
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